Zobrazeno 1 - 10
of 467
pro vyhledávání: '"Richard A. Houghten"'
Autor:
Yangmei Li, Shainnel O. Eans, Michelle Ganno-Sherwood, Abbe Eliasof, Richard A. Houghten, Jay P. McLaughlin
Publikováno v:
Molecules, Vol 28, Iss 22, p 7548 (2023)
Peptide-based opioid ligands are important candidates for the development of novel, safer, and more effective analgesics to treat pain. To develop peptide-based safer analgesics, we synthesized a mixture-based cyclic pentapeptide library containing a
Externí odkaz:
https://doaj.org/article/a54656c2537040219523f325ecf69be0
Autor:
Mark D. Ericson, Katie T. Freeman, Travis M. LaVoi, Haley M. Donow, Radleigh G. Santos, Marc A. Giulianotti, Clemencia Pinilla, Richard A. Houghten, Carrie Haskell-Luevano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10145 (2023)
The melanocortin receptors are involved in numerous physiological pathways, including appetite, skin and hair pigmentation, and steroidogenesis. In particular, the melanocortin-3 receptor (MC3R) is involved in fat storage, food intake, and energy hom
Externí odkaz:
https://doaj.org/article/9855da881bfc4feea75d11f34066b55c
Autor:
Manikandan Palrasu, Anna M. Knapinska, Juan Diez, Lyndsay Smith, Travis LaVoi, Mac Giulianotti, Richard A. Houghten, Gregg B. Fields, Dmitriy Minond
Publikováno v:
Cellular Physiology and Biochemistry, Vol 53, Iss 4, Pp 656-686 (2019)
Externí odkaz:
https://doaj.org/article/0badd010127e4b48b2a91a8683dd94db
Autor:
Joel Gil, Irena Pastar, Richard A. Houghten, Shruti Padhee, Alexander Higa, Michael Solis, Jose Valdez, Cheyanne R. Head, Heather Michaels, Brian Lenhart, Colin Simms, Brandon Williams, Predrag Cudic, Stephen C. Davis
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Both acute and chronic cutaneous wounds are often difficult to treat due to the high-risk for bacterial contamination. Once hospitalized, open wounds are at a high-risk for developing hospital-associated infections caused by multi drug-resistant bact
Externí odkaz:
https://doaj.org/article/bde453d3eb6146d09b0c70ef44e3540d
Autor:
Renee M. Fleeman, Ginamarie Debevec, Kirsten Antonen, Jessie L. Adams, Radleigh G. Santos, Gregory S. Welmaker, Richard A. Houghten, Marc A. Giulianotti, Lindsey N. Shaw
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
We have previously reported the use of combinatorial chemistry to identify broad-spectrum antibacterial agents. Herein, we extend our analysis of this technology toward the discovery of anti-resistance molecules, focusing on efflux pump inhibitors. U
Externí odkaz:
https://doaj.org/article/809cb367f5204c5297109ac02c5ee8ea
Autor:
Richard A. Houghten, Larry A. Sklar, Bruce S. Edwards, Marc A. Giulianotti, Jon R. Appel, Radleigh G. Santos, Clemencia Pinilla
Publikováno v:
Molecules, Vol 18, Iss 6, Pp 6408-6424 (2013)
In the past 20 years, synthetic combinatorial methods have fundamentally advanced the ability to synthesize and screen large numbers of compounds for drug discovery and basic research. Mixture-based libraries and positional scanning deconvolution com
Externí odkaz:
https://doaj.org/article/b974e2ed0f72410596a318605633433d
Autor:
Haskell-Luevano, Mark D. Ericson, Katie T. Freeman, Travis M. LaVoi, Haley M. Donow, Radleigh G. Santos, Marc A. Giulianotti, Clemencia Pinilla, Richard A. Houghten, Carrie
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10145
The melanocortin receptors are involved in numerous physiological pathways, including appetite, skin and hair pigmentation, and steroidogenesis. In particular, the melanocortin-3 receptor (MC3R) is involved in fat storage, food intake, and energy hom
Autor:
Courtney M Larson, Radleigh Santos, Richard A. Houghten, Mark D. Ericson, Katie T. Freeman, Zoe M. Koerperich, Rachel H Cho, Haley M. Donow, Clemencia Pinilla, Skye R. Doering, Travis M. Lavoi, Carrie Haskell-Luevano, Marc A. Giulianotti
Publikováno v:
J Med Chem
The melanocortin-4 receptor (MC4R) plays an important role in appetite. Agonist ligands that stimulate the MC4R decrease appetite, while antagonist compounds increase food consumption. Herein, a functional mixture-based positional scan identified nov
Autor:
Phaedra Geer, Marc A. Giulianotti, Skye R. Doering, Travis M. Lavoi, Mark D. Ericson, Radleigh Santos, Katie T. Freeman, Carrie Haskell-Luevano, Richard A. Houghten, Jon R. Appel, Ginamarie Debevec, Clemencia Pinilla
Publikováno v:
J Med Chem
The central melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are key regulators of body weight and energy homeostasis. Herein, the discovery and characterization of first-in-class small molecule melanocortin agonists with selectivity for the
Publikováno v:
Current Protocols. 2
This article presents a combinatorial library method that consists of the synthesis and screening of mixture-based synthetic combinatorial libraries of peptide molecules to identify B and T cell epitopes. The protocols employ peptide libraries to ide