Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Richard A. Hartz"'
Autor:
Brian McAuliffe, Paul Falk, Jie Chen, Yan Chen, Sing-Yuen Sit, Jacob Swidorski, Richard A. Hartz, Li Xu, Brian Venables, Ny Sin, Nicholas A. Meanwell, Alicia Regueiro-Ren, David Wensel, Umesh Hanumegowda, Mark Krystal
Publikováno v:
Viruses, Vol 16, Iss 10, p 1508 (2024)
The HIV-1 maturation inhibitor (MI) VH3739937 (VH-937) inhibits cleavage between capsid and spacer peptide 1 and exhibits an oral half-life in humans compatible with once-weekly dosing. Here, the antiviral properties of VH-937 are described. VH-937 e
Externí odkaz:
https://doaj.org/article/51872be0e27c430c8414ea5cea778b31
Autor:
Richard A. Hartz, Vijay T. Ahuja, Prasanna Sivaprakasam, Hong Xiao, Carol M. Krause, Wendy J. Clarke, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R. Burton, John E. Macor, Gene M. Dubowchik
Publikováno v:
Journal of Medicinal Chemistry. 66:4231-4252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0e6aab6246e0fca5a7a308d8d66217
https://doi.org/10.1021/acs.jmedchem.3c00133
https://doi.org/10.1021/acs.jmedchem.3c00133
Autor:
Richard A. Hartz, Li Xu, Sing-Yuen Sit, Jie Chen, Brian L. Venables, Zeyu Lin, Sharon Zhang, Zhufang Li, Dawn Parker, Tara S. Simmons, Susan Jenkins, Umesh M. Hanumegowda, Ira Dicker, Mark Krystal, Nicholas A. Meanwell, Alicia Regueiro-Ren
Publikováno v:
Journal of Medicinal Chemistry. 65:15935-15966
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50f57da166571042a230fdc9c14ab8fe
https://doi.org/10.1021/acs.jmedchem.2c01618
https://doi.org/10.1021/acs.jmedchem.2c01618
Autor:
Richard A. Hartz, Vijay T. Ahuja, Guanglin Luo, Ling Chen, Prasanna Sivaprakasam, Hong Xiao, Carol M. Krause, Wendy J. Clarke, Songmei Xu, John S. Tokarski, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R. Burton, John E. Macor, Gene M. Dubowchik
Publikováno v:
Journal of Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::973dc3947e6104a7b54e9172d7ba1d5f
https://doi.org/10.1021/acs.jmedchem.3c00364
https://doi.org/10.1021/acs.jmedchem.3c00364
Autor:
Ivan Lozić, Richard V. Hartz, Carole A. Bartlett, Jeremy A. Shaw, Michael Archer, Priya S.R. Naidu, Nicole M. Smith, Sarah A. Dunlop, K. Swaminathan Iyer, Matt R. Kilburn, Melinda Fitzgerald
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 152-156 (2016)
Before using nanoparticles for therapeutic applications, it is necessary to comprehensively investigate nanoparticle effects, both in vitro and in vivo. In the associated research article [1] we generate multimodal polymeric nanoparticles functionali
Externí odkaz:
https://doaj.org/article/bc239b9e75b54ba4a6aa514391f99583
Autor:
Richard A. Hartz, Vijay T. Ahuja, Susheel J. Nara, C. M. Vijaya Kumar, Raju K. V. L. P. Manepalli, Sarat Kumar Sarvasiddhi, Swarnamba Honkhambe, Vidya Patankar, Bireshwar Dasgupta, Ramkumar Rajamani, Jodi K. Muckelbauer, Daniel M. Camac, Kaushik Ghosh, Matthew Pokross, Susan E. Kiefer, Jeffrey M. Brown, Lisa Hunihan, Michael Gulianello, Martin Lewis, Jonathan S. Lippy, Neha Surti, Brian D. Hamman, Jason Allen, Walter A. Kostich, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba
Publikováno v:
Journal of Medicinal Chemistry. 65:4121-4155
Adaptor protein 2-associated kinase 1 (AAK1) is a serine/threonine kinase that was identified as a therapeutic target for the potential treatment of neuropathic pain. Inhibition of AAK1 in the central nervous system, particularly within the spinal co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8405e1499645d3ed53e06501113a564
https://doi.org/10.1021/acs.jmedchem.1c01966
https://doi.org/10.1021/acs.jmedchem.1c01966
Autor:
Alicia Regueiro-Ren, Sing-Yuen Sit, Yan Chen, Jie Chen, Jacob J. Swidorski, Zheng Liu, Brian L. Venables, Ny Sin, Richard A. Hartz, Tricia Protack, Zeyu Lin, Sharon Zhang, Zhufang Li, Dauh-Rurng Wu, Peng Li, James Kempson, Xiaoping Hou, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Hyunsoo Park, Amy Sarjeant, Yulia Benitex, Sandhya Rahematpura, Dawn Parker, Thomas Phillips, Roy Haskell, Susan Jenkins, Kenneth S. Santone, Mark Cockett, Umesh Hanumegowda, Ira Dicker, Nicholas A. Meanwell, Mark Krystal
Publikováno v:
Journal of medicinal chemistry. 65(18)
GSK3640254 is an HIV-1 maturation inhibitor (MI) that exhibits significantly improved antiviral activity toward a range of clinically relevant polymorphic variants with reduced sensitivity toward the second-generation MI GSK3532795 (BMS-955176). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd326815d3682de3b91571d910517928
https://pubmed.ncbi.nlm.nih.gov/36044257
https://pubmed.ncbi.nlm.nih.gov/36044257
Autor:
Jodi K. Muckelbauer, Ramkumar Rajamani, Jeffrey M. Brown, C M Vijaya Kumar, Kumaran Dandapani, Jonathan Lippy, Saravanan Elavazhagan, Vijay T. Ahuja, John E. Macor, Carolyn Diane Dzierba, Brian D. Hamman, Walter Kostich, Michael Gulianello, Manoj Dokania, Susan E. Kiefer, Susheel J. Nara, Joanne J. Bronson, Amy Easton, Richard A. Hartz, Linda J. Bristow, Martin A. Lewis, Jason Allen, Sreenivasulu N Pattipati, Neha Surti, Lisa Hunihan, Daniel M. Camac
Publikováno v:
Journal of medicinal chemistry. 64(15)
Effective treatment of chronic pain, in particular neuropathic pain, without the side effects that often accompany currently available treatment options is an area of significant unmet medical need. A phenotypic screen of mouse gene knockouts led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a874893d7c1ec730ba639d989c3f7ccd
https://pubmed.ncbi.nlm.nih.gov/34270254
https://pubmed.ncbi.nlm.nih.gov/34270254
Autor:
Dipal Patel, Dong Cheng, Li Xu, Jinal K Shukla, Bruce A. Ellsworth, Nadine Lemos, Harinath Sale, Brett R. Beno, Kaushik Ghosh, Richard A. Hartz, Shashyendra Singh Gautam, Anoop Kumar, Devang Shah, Amit Kumar, Narasimharaju Kalidindi, Alicia Regueiro-Ren
Publikováno v:
Journal of medicinal chemistry. 64(10)
Galectin-3 is a member of a family of β-galactoside-binding proteins. A substantial body of literature reports that galectin-3 plays important roles in cancer, inflammation, and fibrosis. Small-molecule galectin-3 inhibitors, which are generally lac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcb6657a19a0b4a15c795e845a61e2f
https://pubmed.ncbi.nlm.nih.gov/33988358
https://pubmed.ncbi.nlm.nih.gov/33988358
Autor:
Joanne J. Bronson, Nicholas J. Lodge, John E. Macor, James E. Grace, Richard A. Hartz, Vivekananda M. Vrudhula, Vijay T. Ahuja
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1360-1363
A series of phosphate and ester-based prodrugs of anilinopyrazinone 1 (BMS-665053) containing either a methylene or an (acyloxy)alkoxy linker was prepared and evaluated in rat pharmacokinetic studies with the goal of improving the oral bioavailabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1644f9a096b5c2af1329f812cc477fe1
https://doi.org/10.1016/j.bmcl.2017.02.015
https://doi.org/10.1016/j.bmcl.2017.02.015