Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Richard A. Firtel"'
Publikováno v:
Environmental Microbiology. 20:1888-1903
The migration of cells according to a diffusible chemical signal in their environment is called chemotaxis, and the slime mold Dictyostelium discoideum is widely used for the study of eukaryotic chemotaxis. Dictyostelium must sense chemicals, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5323131110ff28647e386a82b212f03b
https://doi.org/10.1111/1462-2920.14126
https://doi.org/10.1111/1462-2920.14126
Autor:
Inbal Hecht, Monica L Skoge, Pascale G Charest, Eshel Ben-Jacob, Richard A Firtel, William F Loomis, Herbert Levine, Wouter-Jan Rappel
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 6, p e1002044 (2011)
Many eukaryotic cells are able to crawl on surfaces and guide their motility based on environmental cues. These cues are interpreted by signaling systems which couple to cell mechanics; indeed membrane protrusions in crawling cells are often accompan
Externí odkaz:
https://doaj.org/article/afb2ea48273a404fadbf0be2a0267721
Publikováno v:
Small GTPases
Small GTPases, 9(4), 360-364
Small GTPases, 9(4), 360-364
The directional movement toward extracellular chemical gradients, a process called chemotaxis, is an important property of cells. Central to eukaryotic chemotaxis is the molecular mechanism by which chemoattractant-mediated activation of G-protein co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcce0614d091073b08fce87d040e42f1
https://doi.org/10.1080/21541248.2016.1235390
https://doi.org/10.1080/21541248.2016.1235390
Autor:
Joshua Francois, Cindy Ayala, Shu Chien, Juan C. Lasheras, Richard A. Firtel, Juan C. del Álamo, Yi-Ting Yeh
Publikováno v:
Biophysical Journal. 118:602a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea30e6e59f18a43a985a6d71369c1b68
https://doi.org/10.1016/j.bpj.2019.11.3255
https://doi.org/10.1016/j.bpj.2019.11.3255
Autor:
Juan C. del Álamo, Begoña Álvarez-González, Effie Bastounis, Juan C. Lasheras, Ruedi Meili, Richard A. Firtel
Publikováno v:
Biophysical Journal. 108:821-832
Fast amoeboid migration requires cells to apply mechanical forces on their surroundings via transient adhesions. However, the role these forces play in controlling cell migration speed remains largely unknown. We used three-dimensional force microsco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cdd4b72d0b5c538d6ecf280d8bc0f4
https://doi.org/10.1016/j.bpj.2014.11.3478
https://doi.org/10.1016/j.bpj.2014.11.3478
Autor:
Zhouxin Shen, Jing Wei, Richard A. Firtel, Kimberly Baumgardner, Steven P. Briggs, Jesus Lacal Romero
Publikováno v:
Developmental biology. 435(1)
GSK3 plays a central role in orchestrating key biological signaling pathways, including cell migration. Here, we identify GlkA as a GSK3 family kinase with functions that overlap with and are distinct from those of GskA. We show that GlkA, as previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1260f4cec5f8520910902369b6daddfc
https://pubmed.ncbi.nlm.nih.gov/29355521
https://pubmed.ncbi.nlm.nih.gov/29355521
Autor:
John M. Asara, Hirofumi Yoshino, Kosuke Takeda, Mika Sasaki, Pascale G. Charest, Dimitrios Anastasiou, Nazanin Majd, Kazutaka Sumita, Hidenori Takahashi, Atsuo T. Sasaki, Emily Rose Kahoud, Koh Takeuchi, Richard A. Firtel, Susan Lee, Taruho S. Kuroda
Publikováno v:
Journal of Biological Chemistry. 289:3950-3959
Mammalian cells encode three closely related Ras proteins, H-Ras, N-Ras, and K-Ras. Oncogenic K-Ras mutations frequently occur in human cancers, which lead to dysregulated cell proliferation and genomic instability. However, mechanistic role of the R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9687a62ec86b68bb66e2f236b07912
https://doi.org/10.1074/jbc.m113.531178
https://doi.org/10.1074/jbc.m113.531178
Autor:
Juan C. del Álamo, Ruedi Meili, Begoña Álvarez-González, Shun Zhang, Manuel Gomez-Gonzalez, Richard A. Firtel, Juan C. Lasheras
Publikováno v:
Scientific reports, vol 7, iss 1
Scientific Reports
Scientific Reports
Cellular traction force microscopy (TFM) requires knowledge of the mechanical properties of the substratum where the cells adhere to calculate cell-generated forces from measurements of substratum deformation. Polymer-based hydrogels are broadly used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddaa14d3ad9112d4106f58129fcd93a
https://escholarship.org/uc/item/28f5x7br
https://escholarship.org/uc/item/28f5x7br
Autor:
Douglas N. Robinson, Yixin Ren, Miho Iijima, Yee Seir Kee, Richard A. Firtel, Danielle Dorfman, Pablo A. Iglesias
Publikováno v:
Molecular Biology of the Cell
A mechanosensory system is characterized that fine-tunes the level of myosin II at the cleavage furrow. This mechanosensory system consists of the mechanosensory module composed of myosin II and cortexillin I and a mechanotransduction loop that inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb928848835afa6dfda0215583594ec
http://europepmc.org/articles/PMC3327329
http://europepmc.org/articles/PMC3327329
Autor:
Paul R. Fisher, Steven P. Briggs, Sebastian Kicka, Sarah J. Annesley, Richard A. Firtel, Susan Lee, Zhouxin Shen
Publikováno v:
Molecular Biology of the Cell
A new pathway that controls pseudopod extension is identified. Results support a model in which Rab1A is required for chemoattractant-mediated Roco2 activation that functions through the F-actin cross-linker filamin to promote pseudopod extension.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b061dbef7f3768f02a4c7c52aeca29
https://doi.org/10.1091/mbc.e10-12-0937
https://doi.org/10.1091/mbc.e10-12-0937