Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Richard A. Dalterio"'
Autor:
Richard A. Hartz, Vivekananda M. Vrudhula, Richard A. Dalterio, David B. Wang-Iverson, Jingfang Qian-Cutrone, Joanne J. Bronson, Vijay T. Ahuja, Dauh-Rurng Wu
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 54:602-606
Pyrazinones bearing an N-1-alkyl chain with a chiral center have been reported as potent antagonists of the corticotropin-releasing factor-1 receptor (CRF1R). Separation of individual enantiomers for preclinical testing was an important aspect of lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93558fecc4d4f3a85ddc088d8e5f5142
https://doi.org/10.1016/j.jpba.2010.09.031
https://doi.org/10.1016/j.jpba.2010.09.031
Autor:
Richard A. Dalterio, Ny Sin, Nicholas A. Meanwell, Stella Huang, Xiaohong Liu, Alicia Ng, Brian Lee Venables, Ramkumar Rajamani, Qi Gao
Publikováno v:
Journal of Heterocyclic Chemistry. 46:432-442
A series of isatin oximes was alkylated with alkyl halides and under Mitsunobu conditions to generate O-alkylated oxime ether and N-alkylated nitrone products. Alkylation of the sodium salts of oximes and with alkyl iodides produced predominantly the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c62091bf7c3f21337270cf6a4aa63934
https://doi.org/10.1002/jhet.84
https://doi.org/10.1002/jhet.84
Autor:
Lisa Zadjura, Ivette Medina, Rita L. Civiello, Eugene V. Genovesi, Celia D’Arienzo, Sandra A. Dando, H. Belgin Gulgeze, Anthony M. Marino, Keith D. Combrink, X. Alan Wang, Richard J. Colonno, Christopher Cianci, Nicholas A. Meanwell, Kuo-Long Yu, Richard A. Dalterio, Mark Krystal, Lucinda Lamb, Zheng Yang, J. J. Kim Wright, Kathleen F. Kadow, Brian Lee Venables, Junius Clarke, Zhufang Li, Ny Sin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:895-901
A series of benzimidazole-based inhibitors of respiratory syncytial virus (RSV) fusion were optimized for antiviral potency, membrane permeability and metabolic stability in human liver microsomes. 1-Cyclopropyl-1,3-dihydro-3-[[1-(4-hydroxybutyl)-1H-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f0b15de4e6b963a15896b9c356593f
https://doi.org/10.1016/j.bmcl.2006.11.063
https://doi.org/10.1016/j.bmcl.2006.11.063
Autor:
Ira B. Dicker, Hua Fang, James E. Robinson, Pin-Fang Lin, John D. Matiskella, Brian McAuliffe, Nannan Zhou, Li Fan, Richard A. Dalterio, Paul R. Clapham, Gregory Yamanaka, John F. Kadow, Yi-Fei Gong, Richard J. Colonno, Tao Wang, Beata Nowicka-Sans, Chang-Ben Li, Yasutsugu Ueda, Hsu-Tso Ho, Zhiwei Yin
Publikováno v:
Journal of Virology. 80:4017-4025
BMS-488043 is a small-molecule human immunodeficiency virus type 1 (HIV-1) CD4 attachment inhibitor with demonstrated clinical efficacy. The compound inhibits soluble CD4 (sCD4) binding to the 11 distinct HIV envelope gp120 proteins surveyed. Binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c713f3c52146165182ed639537f83a
https://doi.org/10.1128/jvi.80.8.4017-4025.2006
https://doi.org/10.1128/jvi.80.8.4017-4025.2006
Autor:
Christopher Cianci, Zhufang Li, David R. Langley, Julia Roach, Douglas D. Dischino, Richard A. Dalterio, Richard J. Colonno, Yaxiong Sun, Kuo-Long Yu, Mark Krystal, Nicholas A. Meanwell, Anne Stanley
Publikováno v:
Proceedings of the National Academy of Sciences. 101:15046-15051
Trimeric class I virus fusion proteins undergo a series of conformational rearrangements that leads to the association of C- and N-terminal heptad repeat domains in a “trimer-of-hairpins” structure, facilitating the apposition of viral and cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e082a295dd60e88d0a95766b089dafc
https://doi.org/10.1073/pnas.0406696101
https://doi.org/10.1073/pnas.0406696101
Autor:
Richard A. Dalterio, Pamela A. Trail, Dalton King, Michael A. Walker, Gene M. Dubowchik, Raymond A. Firestone
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4323-4327
The potency of tallysomycin S(10b) (TLM S(10b)) an analogue bleomycin was enhanced by up to 875-fold when it was conjugated to the internalizing antibody BR96. Attachment to the antibody is achieved via a Cathepsin B cleavable linker. The enhancement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7282c0abbacb25710554990639e91b71
https://doi.org/10.1016/j.bmcl.2004.05.089
https://doi.org/10.1016/j.bmcl.2004.05.089
Autor:
Steven E. Klohr, Stella Huang, Richard A. Dalterio, Jingfang Qian-Cutrone, Li-Ping Chang, Susan E. Lowe, Dolores M. Pirnik, M. Alam, Kathleen F. Kadow, Robert Hugill
Publikováno v:
The Journal of Antibiotics. 49:990-997
During the screening of the natural products for their ability to inhibit the binding of REV (regulation of virion expression) protein to [33P] labeled RRE (REV responsive element) RNA, two novel fungal metabolites, harziphilone and fleephilone, were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9bff4170815018fa67f969ebfafe69
https://doi.org/10.7164/antibiotics.49.990
https://doi.org/10.7164/antibiotics.49.990
Autor:
Steven E. Klohr, Richard A. Dalterio, Jingfang Qian-Cutrone, Li-Ping Chang, Susan E. Lowe, Stella Huang, Robert Hugill, Kathleen F. Kadow, Dolores M. Pirnik, M. Alam
Publikováno v:
ChemInform. 28
During the screening of the natural products for their ability to inhibit the binding of REV (regulation of virion expression) protein to [33P] labeled RRE (REV responsive element) RNA, two novel fungal metabolites, harziphilone and fleephilone, were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec7c7c118f890ca82ef218b5a5efea47
https://doi.org/10.1002/chin.199713209
https://doi.org/10.1002/chin.199713209
Autor:
Ramkumar Rajamani, Alicia Ng, Qi Gao, Brian Lee Venables, Xiaohong Liu, Stella Huang, Nicholas A. Meanwell, Richard A. Dalterio, Ny Sin
Publikováno v:
ChemInform. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d069a9e28da3b752fed661a1e4fba1
https://doi.org/10.1002/chin.200941112
https://doi.org/10.1002/chin.200941112
Autor:
Andrew P. Degnan, Charles M. Conway, Richard Schartman, Cen Xu, John E. Macor, Richard A. Dalterio, Robert Macci, Stephen E. Mercer, Gene M. Dubowchik
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(13)
The calcitonin gene-related peptide (CGRP) receptor has been implicated in the pathogenesis of migraine. A class of urethanamide derivatives has been identified as potent inhibitors of the CGRP receptor. Compound 20 was found to be among the most pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95006fcdbe8f416975a12c6c59656fcc
https://pubmed.ncbi.nlm.nih.gov/19467597
https://pubmed.ncbi.nlm.nih.gov/19467597