Výsledky vyhledávání - "Richard A. Carano"

Akademický článek

Automated segmentation of lungs and lung tumors in mouse micro-CT scans

Autor: Gregory Z. Ferl, Kai H. Barck, Jasmine Patil, Skander Jemaa, Evelyn J. Malamut, Anthony Lima, Jason E. Long, Jason H. Cheng, Melissa R. Junttila, Richard A.D. Carano

Publikováno v: iScience, Vol 25, Iss 12, Pp 105712- (2022)

Summary: Here, we have developed an automated image processing algorithm for segmenting lungs and individual lung tumors in in vivo micro-computed tomography (micro-CT) scans of mouse models of non-small cell lung cancer and lung fibrosis. Over 3000

Externí odkaz: https://doaj.org/article/067c962811db439da9d3f24eeac1f62b

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Akademický článek

Deformation-based morphometry identifies deep brain structures protected by ocrelizumab

Autor: Zhuang Song, Anithapriya Krishnan, Laura Gaetano, Nicholas J. Tustison, David Clayton, Alex de Crespigny, Thomas Bengtsson, Xiaoming Jia, Richard A.D. Carano

Publikováno v: NeuroImage: Clinical, Vol 34, Iss , Pp 102959- (2022)

Background: Despite advancements in treatments for multiple sclerosis, insidious disease progression remains an area of unmet medical need, for which atrophy-based biomarkers may help better characterize the progressive biology. Methods: We developed

Externí odkaz: https://doaj.org/article/f33d9eb048974392882708206b4b1e98

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Akademický článek

VCAM-1 Density and Tumor Perfusion Predict T-cell Infiltration and Treatment Response in Preclinical Models

Autor: Johannes Riegler, Herman Gill, Annie Ogasawara, Maj Hedehus, Vincent Javinal, Jason Oeh, Gregory Z. Ferl, Jan Marik, Simon Williams, Deepak Sampath, Jill Schartner, Richard A.D. Carano

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 10, Pp 1036-1050 (2019)

Cancer immunotherapies have demonstrated durable responses in a range of different cancers. However, only a subset of patients responds to these therapies. We set out to test if non-invasive imaging of tumor perfusion and vascular inflammation may be

Externí odkaz: https://doaj.org/article/741a375fc66146b38b3c4feb55c71ce8

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Akademický článek

Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS

Publikováno v: Neurobiology of Disease, Vol 124, Iss , Pp 340-352 (2019)

Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the disease, therapeutics that prev

Externí odkaz: https://doaj.org/article/cd3e464eb6fd4c10b7ea4c66731e7e28

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Akademický článek

Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19F–MRI and Multispectral Analysis

Autor: Yunzhou Shi, Jason Oeh, Anna Hitz, Maj Hedehus, Jeffrey Eastham-Anderson, Franklin V. Peale, Jr., Patricia Hamilton, Thomas O'Brien, Deepak Sampath, Richard A.D. Carano

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 11, Pp 950-959 (2017)

The effect of anti-angiogenic agents on tumor oxygenation has been in question for a number of years, where both increases and decreases in tumor pO2 have been observed. This dichotomy in results may be explained by the role of vessel normalization i

Externí odkaz: https://doaj.org/article/1b96baaaac2f4413aedd350f7287303d

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