Zobrazeno 1 - 10
of 1 128
pro vyhledávání: '"Richard A Stein"'
Autor:
Richard A Stein, Hassane S Mchaourab
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010483 (2022)
The unprecedented performance of Deepmind's Alphafold2 in predicting protein structure in CASP XIV and the creation of a database of structures for multiple proteomes and protein sequence repositories is reshaping structural biology. However, because
Externí odkaz:
https://doaj.org/article/609c33a1f29e4631ae4a1132789bdcdb
Autor:
Tanmay S Chavan, Ricky C Cheng, Tao Jiang, Irimpan I Mathews, Richard A Stein, Antoine Koehl, Hassane S Mchaourab, Emad Tajkhorshid, Merritt Maduke
Publikováno v:
eLife, Vol 9 (2020)
Among coupled exchangers, CLCs uniquely catalyze the exchange of oppositely charged ions (Cl– for H+). Transport-cycle models to describe and explain this unusual mechanism have been proposed based on known CLC structures. While the proposed models
Externí odkaz:
https://doaj.org/article/b749e602edbc4f7ab3d6e58d1b99d2b3
Autor:
Ruojing Zhang, Kevin L. Jagessar, Matthew Brownd, Adithya Polasa, Richard A. Stein, Mahmoud Moradi, Erkan Karakas, Hassane S. Mchaourab
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Protease-containing ABC transporters (PCATs) couple the energy of ATP hydrolysis to the processing and export of diverse cargo proteins across cell membranes to mediate antimicrobial resistance and quorum sensing. Here, we combine biochemica
Externí odkaz:
https://doaj.org/article/72d05e77de8345499d88934c23f65cbd
Autor:
Chandra M Khantwal, Sherwin J Abraham, Wei Han, Tao Jiang, Tanmay S Chavan, Ricky C Cheng, Shelley M Elvington, Corey W Liu, Irimpan I Mathews, Richard A Stein, Hassane S Mchaourab, Emad Tajkhorshid, Merritt Maduke
Publikováno v:
eLife, Vol 5 (2016)
CLC secondary active transporters exchange Cl- for H+. Crystal structures have suggested that the conformational change from occluded to outward-facing states is unusually simple, involving only the rotation of a conserved glutamate (Gluex) upon its
Externí odkaz:
https://doaj.org/article/412dc066a96c480c9b531c04b7b4fecb
Autor:
Smriti Mishra, Brandy Verhalen, Richard A Stein, Po-Chao Wen, Emad Tajkhorshid, Hassane S Mchaourab
Publikováno v:
eLife, Vol 3 (2014)
Multidrug ATP binding cassette (ABC) exporters are ubiquitous ABC transporters that extrude cytotoxic molecules across cell membranes. Despite recent progress in structure determination of these transporters, the conformational motion that transduces
Externí odkaz:
https://doaj.org/article/dc43a4c8e1ad4adda06402c28b5e6e11
Autor:
Nathan S Alexander, Richard A Stein, Hanane A Koteiche, Kristian W Kaufmann, Hassane S McHaourab, Jens Meiler
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72851 (2013)
An increasingly used parameter in structural biology is the measurement of distances between spin labels bound to a protein. One limitation to these measurements is the unknown position of the spin label relative to the protein backbone. To overcome
Externí odkaz:
https://doaj.org/article/04ec2ad22c394b5493816ad6c96dc733
Autor:
Qingyu Tang, Matt Sinclair, Hale S. Hasdemir, Richard A. Stein, Erkan Karakas, Emad Tajkhorshid, Hassane S. Mchaourab
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Here we used cryo-electron microscopy (cryo-EM), double electron-electron resonance spectroscopy (DEER), and molecular dynamics (MD) simulations, to capture and characterize ATP- and substrate-bound inward-facing (IF) and occluded (OC) confo
Externí odkaz:
https://doaj.org/article/a047436bdf4c4cb998566188a7b94142
Autor:
Richard A. Stein
Publikováno v:
Genetic Engineering & Biotechnology News. 43:36-38, 40, 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f46fa78d902e44401e898794d9fdc4
https://doi.org/10.1089/gen.43.05.12
https://doi.org/10.1089/gen.43.05.12
Autor:
Richard A. Stein
Publikováno v:
Genetic Engineering & Biotechnology News. 43:44-47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24e3230549ce56b1f8e4b7b9df495c08
https://doi.org/10.1089/gen.43.02.15
https://doi.org/10.1089/gen.43.02.15
Autor:
Richard A. Stein
Publikováno v:
ACS Infectious Diseases. 8:1981-1991
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8c77e0389d63a22ab6b83d7c4ca3fa5
https://doi.org/10.1021/acsinfecdis.2c00397
https://doi.org/10.1021/acsinfecdis.2c00397