Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Richard A Slayden"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 11, p e0011795 (2023)
Burkholderia pseudomallei is the causative agent of melioidosis, which is increasingly being reported worldwide. Mortality rates as high as 40% have been reported based on clinical patient outcomes in the endemic areas of Australia and Thailand. Nove
Externí odkaz:
https://doaj.org/article/507864f1f55e4eee9340ff09864717bb
Autor:
Collin M Bantle, C Tenley French, Jason E Cummings, Shankar Sadasivan, Kevin Tran, Richard A Slayden, Richard J Smeyne, Ronald B Tjalkens
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245171 (2021)
Infection with Influenza A virus can lead to the development of encephalitis and subsequent neurological deficits ranging from headaches to neurodegeneration. Post-encephalitic parkinsonism has been reported in surviving patients of H1N1 infections,
Externí odkaz:
https://doaj.org/article/c6f1ecacc541473c9b389152ae23b0da
Autor:
Jason E Cummings, Richard A Slayden
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 1, p e0005209 (2017)
Much is known about the mode of action of drugs and resistance mechanisms under laboratory growth conditions, but research on the bacterial transcriptional response to drug pressure in vivo or efficacious mode of action and transient resistance mecha
Externí odkaz:
https://doaj.org/article/b2616ee54a944088842aa2e1282b8606
Autor:
William J Wilson, Maryam F Afzali, Jason E Cummings, Marie E Legare, Ronald B Tjalkens, Christopher P Allen, Richard A Slayden, William H Hanneman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005065 (2016)
Melioidosis is caused by the facultative intracellular bacterium Burkholderia pseudomallei and is potentially fatal. Despite a growing global burden and high fatality rate, little is known about the disease. Recent studies demonstrate that cyclooxyge
Externí odkaz:
https://doaj.org/article/66edc4060af546d18cef03821edc386c
Autor:
Susan E Knudson, Divya Awasthi, Kunal Kumar, Alexandra Carreau, Laurent Goullieux, Sophie Lagrange, Hélèn Vermet, Iwao Ojima, Richard A Slayden
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93953 (2014)
Trisubstituted benzimidazoles have demonstrated potency against Gram-positive and Gram-negative bacterial pathogens. Previously, a library of novel trisubstituted benzimidazoles was constructed for high throughput screening, and compounds were identi
Externí odkaz:
https://doaj.org/article/07b55a1f9972459fb958b169883595ff
Autor:
Linsen Li, Steffen Lindert, Yanran Lu, Anna Chen, Jason E. Cummings, Chelsea A Mann, Sandip Vibhute, Brieanna Roth, Anthony English, Sheri Nolan, Mark J. Mitton-Fry, Daniel J. Wozniak, Steven C Ratigan, Richard A. Slayden, Jack C. Yalowich, Bryan Koci, Antony A. Okumu, Jonathan L. Papa, Craig A. McElroy, Justin T Seffernick, Leonard R Duncan
Publikováno v:
Journal of Medicinal Chemistry. 64:15214-15249
Novel bacterial topoisomerase inhibitors (NBTIs) are among the most promising new antibiotics in preclinical/clinical development. We previously reported dioxane-linked NBTIs with potent antistaphylococcal activity and reduced hERG inhibition, a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3892c880ddb3b3758eba4c921a02b47
https://doi.org/10.1021/acs.jmedchem.1c01250
https://doi.org/10.1021/acs.jmedchem.1c01250
Autor:
Savannah M. Rocha, Anna C. Fagre, Amanda S. Latham, Jason E. Cummings, Tawfik A. Aboellail, Philip Reigan, Devin A. Aldaz, Casey P. McDermott, Katriana A. Popichak, Rebekah C. Kading, Tony Schountz, Neil D. Theise, Richard A. Slayden, Ronald B. Tjalkens
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite significant research efforts, treatment options for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain limited. This is due in part to a lack of therapeutics that increase host defense to the virus. Replication of SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34aefef5df1c9e4ab8b47832a2bdc92
https://www.frontiersin.org/articles/10.3389/fimmu.2022.811430/full
https://www.frontiersin.org/articles/10.3389/fimmu.2022.811430/full
Publikováno v:
JAC-antimicrobial resistance. 4(2)
Background NIAID has a programme for testing drug candidates against biodefense and emerging bacterial pathogens that uses defined strain panels consisting of standard laboratory reference strains and strains of clinical origin. Objectives The curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77dbcdf06625939da27364ac92e9c7e0
https://pubmed.ncbi.nlm.nih.gov/35350133
https://pubmed.ncbi.nlm.nih.gov/35350133
Autor:
Yanran, Lu, Sandip, Vibhute, Linsen, Li, Antony, Okumu, Steven C, Ratigan, Sheri, Nolan, Jonathan L, Papa, Chelsea A, Mann, Anthony, English, Anna, Chen, Justin T, Seffernick, Bryan, Koci, Leonard R, Duncan, Brieanna, Roth, Jason E, Cummings, Richard A, Slayden, Steffen, Lindert, Craig A, McElroy, Daniel J, Wozniak, Jack, Yalowich, Mark J, Mitton-Fry
Publikováno v:
Journal of medicinal chemistry. 64(20)
Novel bacterial topoisomerase inhibitors (NBTIs) are among the most promising new antibiotics in preclinical/clinical development. We previously reported dioxane-linked NBTIs with potent antistaphylococcal activity and reduced hERG inhibition, a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc8f7442e2cb53241c3d17ad1ee5eb4c
https://pubmed.ncbi.nlm.nih.gov/34614347
https://pubmed.ncbi.nlm.nih.gov/34614347
Publikováno v:
JAC-Antimicrobial Resistance
Background Francisella tularensis is a highly virulent and contagious Gram-negative intracellular bacterium that causes the disease tularaemia in mammals and is classified as a Category A priority pathogen. Methods We utilized a systematic analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdbee67ef6ee6970eb0d4645790ee1c
https://doi.org/10.1093/jacamr/dlab058
https://doi.org/10.1093/jacamr/dlab058