Výsledky vyhledávání - "Richard A Rippe"

Akademický článek

Distinct populations of hepatic stellate cells in the mouse liver have different capacities for retinoid and lipid storage.

Autor: Diana N D'Ambrosio, José L Walewski, Robin D Clugston, Paul D Berk, Richard A Rippe, William S Blaner

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24993 (2011)

Hepatic stellate cell (HSC) lipid droplets are specialized organelles for the storage of retinoid, accounting for 50-60% of all retinoid present in the body. When HSCs activate, retinyl ester levels progressively decrease and the lipid droplets are l

Externí odkaz: https://doaj.org/article/2880848f92ba4eed9f50e0a54e4afe1b

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Fibrocytes Are Not an Essential Source of Type I Collagen during Lung Fibrosis

Autor: Kevin K. Kim, Jibing Yang, Richard A. Rippe, Kathryn R. Kleaveland, Miranda Velikoff, Manisha Agarwal, Bethany B. Moore

Publikováno v: The Journal of Immunology. 193:5229-5239

Progressive fibrosis involves accumulation of activated collagen-producing mesenchymal cells. Fibrocytes are hematopoietic-derived cells with mesenchymal features that potentially have a unique and critical function during fibrosis. Fibrocytes have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b913c10e3982c51c6ae2cdf5e6384c
https://doi.org/10.4049/jimmunol.1400753

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S-adenosyl-l-methionine inhibits collagen secretion in hepatic stellate cells via increased ubiquitination

Autor: Richard A. Rippe, Brian W. Cross, Iain H. McKillop, Shigeki Tsukada, Laura W. Schrum, Ashley M. Lakner, Kyle J. Thompson

Publikováno v: Liver International. 31:891-901

Background: Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) components that disrupt normal liver microcirculation and lead to organ injury. Hepatic stellate cells (HSCs), following transdifferentiation, are the central medi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d019359680f6baeb6195ee4cc60abbf6
https://doi.org/10.1111/j.1478-3231.2011.02512.x

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Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis

Autor: Ashley W. Perry, Emmanuel Thomas, Nico van Rooijen, Richard A. Rippe, Ian N. Hines, Richard J. Milton, Michael W. Fried, Michael Kremer, Michael D. Wheeler, Steven Zacks

Publikováno v: Hepatology, 51(1), 130-141. John Wiley and Sons Ltd
Kremer, M, Thomas, E, Milton, R J, Perry, A W, van Rooijen, N, Wheeler, M D, Zacks, S, Fried, M, Rippe, R A & Hines, I N 2010, ' Kupffer Cell and Interleukin-12-Dependent Loss of Natural Killer T Cells in Hepatosteatosis ', Hepatology, vol. 51, no. 1, pp. 130-141 . https://doi.org/10.1002/hep.23292

Hepatosteatosis is associated with increased expression of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-12, major T helper (Th) 1 cytokines, and reduced hepatic natural killer T (NKT) cell numbers. The relationship between lipid accumula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868a5cec0d9526873c676e5c0afb488c
https://doi.org/10.1002/hep.23292

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Ethanol Self-Administration and Alterations in the Livers of the Cynomolgus Monkey, Macaca fascicularis

Autor: Carol C. Cunningham, David Friedman, Kathleen A. Grant, Priscilla Ivester, Tracey Young, Jennifer Young, James B. Daunais, Diana M. Stafforini, L. Jackson Roberts, Cynthia J. Lees, Richard A. Rippe, Jeffrey A. Vivian, Christopher J. Parsons

Publikováno v: Alcoholism: Clinical and Experimental Research. 31:144-155

Background: Most of the studies of alcoholic liver disease use models in which animals undergo involuntary administration of high amounts of ethanol and consume diets that are often high in polyunsaturated fatty acids. The objectives of this study we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7de8e97c404366b43a0fcb21d175129
https://doi.org/10.1111/j.1530-0277.2006.00276.x

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Mechanisms of liver fibrosis

Autor: Shigeki Tsukada, Richard A. Rippe, Christopher J. Parsons

Publikováno v: Clinica Chimica Acta. 364:33-60

Liver fibrosis represents a significant health problem worldwide of which no acceptable therapy exists. The most characteristic feature of liver fibrosis is excess deposition of type I collagen. A great deal of research has been performed to understa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb30fb4c09c72ab662dced8a112900f
https://doi.org/10.1016/j.cca.2005.06.014

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Peroxisome Proliferator-activated Receptor γ Suppresses Proximal α1(I) Collagen Promoter via Inhibition of p300-facilitated NF-I Binding to DNA in Hepatic Stellate Cells

Autor: Sharon Yavrom, Jiaohong Wang, Shigang Xiong, Hidekazu Tsukamoto, Richard A. Rippe, Li Chen

Publikováno v: Journal of Biological Chemistry. 280:40650-40659

Depletion of peroxisome proliferator-activated receptor gamma (PPARgamma) represents one of the key molecular changes that underlie transdifferentiation (activation) of hepatic stellate cells in the genesis of liver fibrosis (Miyahara, T., Schrum, L.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94bfc5f729e26ce9123da4019fa85a41
https://doi.org/10.1074/jbc.m510094200

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NF-κB activation in Kupffer cells after partial hepatectomy

Autor: Liu Yang, David A. Brenner, Richard A. Rippe, Ramon Bataller, Scott T. Magness

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G530-G538

The transcription factor nuclear factor-kappaB (NF-kappaB) is activated during liver regeneration after partial hepatectomy. However, the physiological role and cellular localization of NF-kappaB activation are unresolved. In this study, we used an a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c678f96b785fc2cc23e0e55086ded263
https://doi.org/10.1152/ajpgi.00526.2004

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Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice

Autor: Ramon Bataller, Pere Ginès, Liu Yang, David A. Brenner, Jennyfer Dulyx, Thomas M. Coffman, Richard A. Rippe

Publikováno v: Journal of Hepatology. 43:317-323

Background/Aims Pharmacological blockade of the renin–angiotensin system (RAS) attenuates liver fibrogenesis in rats. Here, we provide genetic evidence implicating angiotensin type 1 (AT1) receptors in liver fibrogenesis. Methods Wild type (WT) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d12ffacaf32aee5691fa675abbae075
https://doi.org/10.1016/j.jhep.2005.02.034

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Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats

Autor: Christopher J. Parsons, Ramon Bataller, David A. Brenner, Terry Morris, Richard A. Rippe, Liu Yang, Erwin Gäbele, Robert Schoonhoven

Publikováno v: Hepatology. 41:1046-1055

Recent evidence indicates that the renin-angiotensin system (RAS) plays a major role in liver fibrosis. Here, we investigate whether the circulatory RAS, which is frequently activated in patients with chronic liver disease, contributes to fibrosis pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2f9fab7e277efc0ee880adbe384d10
https://doi.org/10.1002/hep.20665

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