Zobrazeno 1 - 10
of 467
pro vyhledávání: '"Richard A Houghten"'
Autor:
Austin B Yongye, Mirella Vivoli, Iris Lindberg, Jon R Appel, Richard A Houghten, Karina Martinez-Mayorga
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56957 (2013)
The calcium-dependent serine endoproteases prohormone convertase 1/3 (PC1/3) and prohormone convertase 2 (PC2) play important roles in the homeostatic regulation of blood glucose levels, hence implicated in diabetes mellitus. Specifically, the absenc
Externí odkaz:
https://doaj.org/article/6f958fffc0a44c8babe76c149820aa7e
Autor:
Yangmei Li, Shainnel O. Eans, Michelle Ganno-Sherwood, Abbe Eliasof, Richard A. Houghten, Jay P. McLaughlin
Publikováno v:
Molecules, Vol 28, Iss 22, p 7548 (2023)
Peptide-based opioid ligands are important candidates for the development of novel, safer, and more effective analgesics to treat pain. To develop peptide-based safer analgesics, we synthesized a mixture-based cyclic pentapeptide library containing a
Externí odkaz:
https://doaj.org/article/a54656c2537040219523f325ecf69be0
Autor:
Mark D. Ericson, Katie T. Freeman, Travis M. LaVoi, Haley M. Donow, Radleigh G. Santos, Marc A. Giulianotti, Clemencia Pinilla, Richard A. Houghten, Carrie Haskell-Luevano
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10145 (2023)
The melanocortin receptors are involved in numerous physiological pathways, including appetite, skin and hair pigmentation, and steroidogenesis. In particular, the melanocortin-3 receptor (MC3R) is involved in fat storage, food intake, and energy hom
Externí odkaz:
https://doaj.org/article/9855da881bfc4feea75d11f34066b55c
Autor:
Joel Gil, Irena Pastar, Richard A. Houghten, Shruti Padhee, Alexander Higa, Michael Solis, Jose Valdez, Cheyanne R. Head, Heather Michaels, Brian Lenhart, Colin Simms, Brandon Williams, Predrag Cudic, Stephen C. Davis
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Both acute and chronic cutaneous wounds are often difficult to treat due to the high-risk for bacterial contamination. Once hospitalized, open wounds are at a high-risk for developing hospital-associated infections caused by multi drug-resistant bact
Externí odkaz:
https://doaj.org/article/bde453d3eb6146d09b0c70ef44e3540d
Autor:
Haskell-Luevano, Mark D. Ericson, Katie T. Freeman, Travis M. LaVoi, Haley M. Donow, Radleigh G. Santos, Marc A. Giulianotti, Clemencia Pinilla, Richard A. Houghten, Carrie
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 12; Pages: 10145
The melanocortin receptors are involved in numerous physiological pathways, including appetite, skin and hair pigmentation, and steroidogenesis. In particular, the melanocortin-3 receptor (MC3R) is involved in fat storage, food intake, and energy hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::76d440bd6940baadf6fdd1aa0c4404ab
Autor:
Courtney M Larson, Radleigh Santos, Richard A. Houghten, Mark D. Ericson, Katie T. Freeman, Zoe M. Koerperich, Rachel H Cho, Haley M. Donow, Clemencia Pinilla, Skye R. Doering, Travis M. Lavoi, Carrie Haskell-Luevano, Marc A. Giulianotti
Publikováno v:
J Med Chem
The melanocortin-4 receptor (MC4R) plays an important role in appetite. Agonist ligands that stimulate the MC4R decrease appetite, while antagonist compounds increase food consumption. Herein, a functional mixture-based positional scan identified nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d799fa35400e843e7186e1fca268b270
https://doi.org/10.1021/acs.jmedchem.1c01417
https://doi.org/10.1021/acs.jmedchem.1c01417
Autor:
Phaedra Geer, Marc A. Giulianotti, Skye R. Doering, Travis M. Lavoi, Mark D. Ericson, Radleigh Santos, Katie T. Freeman, Carrie Haskell-Luevano, Richard A. Houghten, Jon R. Appel, Ginamarie Debevec, Clemencia Pinilla
Publikováno v:
J Med Chem
The central melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are key regulators of body weight and energy homeostasis. Herein, the discovery and characterization of first-in-class small molecule melanocortin agonists with selectivity for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9eb1c484c45bcbe6d841d2afad5501
https://doi.org/10.1021/acs.jmedchem.0c02041
https://doi.org/10.1021/acs.jmedchem.0c02041
Publikováno v:
Current Protocols. 2
This article presents a combinatorial library method that consists of the synthesis and screening of mixture-based synthetic combinatorial libraries of peptide molecules to identify B and T cell epitopes. The protocols employ peptide libraries to ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1da8c0620bae869c79b5e05c823bbf
https://doi.org/10.1002/cpz1.378
https://doi.org/10.1002/cpz1.378
Autor:
Richard A. Houghten, Larry A. Sklar, Bruce S. Edwards, Marc A. Giulianotti, Jon R. Appel, Radleigh G. Santos, Clemencia Pinilla
Publikováno v:
Molecules, Vol 18, Iss 6, Pp 6408-6424 (2013)
In the past 20 years, synthetic combinatorial methods have fundamentally advanced the ability to synthesize and screen large numbers of compounds for drug discovery and basic research. Mixture-based libraries and positional scanning deconvolution com
Externí odkaz:
https://doaj.org/article/b974e2ed0f72410596a318605633433d
Autor:
Ashwini K. Devkota, Ramakrishna Edupunganti, Gabriel Stancu, Richard A. Houghten, Marc A. Giulianotti, Ginamarie Debevec, Garth Powis, Eun Jeong Cho, Kevin N. Dalby
Publikováno v:
SLAS Discovery. 25:1038-1046
Hypoxic solid tumors induce the stabilization of hypoxia-inducible factor 1 alpha (HIF1α), which stimulates the expression of many glycolytic enzymes and hypoxia-responsive genes. A high rate of glycolysis supports the energetic and material needs f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d22d7f108d86147d80059798331d59
https://doi.org/10.1177/2472555220926146
https://doi.org/10.1177/2472555220926146