Výsledky vyhledávání - "Richard A G Smith"

Akademický článek

C1 esterase inhibitor reduces lower extremity ischemia/reperfusion injury and associated lung damage.

Autor: Claudia Duehrkop, Yara Banz, Rolf Spirig, Sylvia Miescher, Marc W Nolte, Martin Spycher, Richard A G Smith, Steven H Sacks, Robert Rieben

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72059 (2013)

BACKGROUND:Ischemia/reperfusion injury of lower extremities and associated lung damage may result from thrombotic occlusion, embolism, trauma, or surgical intervention with prolonged ischemia and subsequent restoration of blood flow. This clinical en

Externí odkaz: https://doaj.org/article/cc69c3666e684bdaa8a06500b0f6f4f5

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An indium-111-labelled membrane-targeted peptide for cell tracking with radionuclide imaging

Autor: Johanna Pruller, Truc Thuy Pham, Julia E. Blower, Putthiporn Charoenphun, Alessia Volpe, Kavitha Sunassee, Gregory E. D. Mullen, Philip J. Blower, Richard A. G. Smith, Michelle T. Ma

Publikováno v: RSC Chemical Biology. 4:65-73

An indium-111-labelled peptide binds to myeloma cells, enabling SPECT imaging of myeloma cell accumulation in lungs after intravenous administration. This is the first report of a radiolabelled cell-membrane binding peptide for cell tracking.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::070d08a57bacd15edc33847edef5af3b
https://doi.org/10.1039/d2cb00164k

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Akademický článek

Regression of Atherosclerosis in ApoE−/− Mice Via Modulation of Monocyte Recruitment and Phenotype, Induced by Weekly Dosing of a Novel 'Cytotopic' Anti‐Thrombin Without Prolonged Anticoagulation

Autor: Daxin Chen, Ke Li, Sam Festenstein, Julieta Karegli, Hannah Wilkinson, Hugh Leonard, Lin‐Lin Wei, Ning Ma, Min Xia, Henry Tam, Jian‐an Wang, Qingbo Xu, John H. McVey, Richard A. G. Smith, Anthony Dorling

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 13 (2020)

Background Anticoagulants induce atherosclerosis regression in animal models but exploiting this clinically is limited by bleeding events. Here we test a novel thrombin inhibitor, PTL060, comprising hirulog covalently linked to a synthetic myristoyl

Externí odkaz: https://doaj.org/article/14b724396b3444ca97b1931d9032ba68

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Akademický článek

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in viv

Externí odkaz: https://doaj.org/article/5939bc54d4b347d7b1b16946d6d5c490

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Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus

Publikováno v: Alzheimer´s & Dementia

Alzheimer’s disease is a neurodegenerative disorder characterized clinically by cognitive decline and pathologically by amyloid deposition and neurofibrillary changes. These neuropathological hallmarks are accompanied by reactive events including m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0876e506d5055bb9da0913d0998881ad
https://doi.org/10.1002/alz.12970

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Ex vivo delivery of Mirococept: A dose-finding study in pig kidney after showing a low dose is insufficient to reduce delayed graft function in human kidney

Autor: Jonathon Olsburgh, Abdel Douiri, Guilherme Danzi, Anass Qasem, Richard A. G. Smith, Theodoros Kassimatis, Clare Flach, Peter J. Friend, Flavia Neri, Steven H. Sacks, James P. Hunter, Laura L. Nichols, Catherine Horsfield, Roseanna Greenlaw, Martin Drage, Irene Rebollo-Mesa, Julieta Karegli

Publikováno v: American Journal of Transplantation. 21:1012-1026

The complement system plays a pivotal role in the pathogenesis of ischemia-reperfusion injury in solid organ transplantation. Mirococept is a potent membrane-localizing complement inhibitor that can be administered ex vivo to the donor kidney prior t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0e402a35a421659f29b3e00ca62f50
https://doi.org/10.1111/ajt.16265

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Targeting Prostate Cancer Using Intratumoral Cytotopically Modified Interleukin-15 Immunotherapy in a Syngeneic Murine Model

Autor: Efthymia Papaevangelou, Prokar Dasgupta, Richard A. G. Smith, Christine Galustian, Dorota Smolarek

Publikováno v: ImmunoTargets and Therapy. 9:115-130

Background The prostate cancer microenvironment is highly immunosuppressive; immune cells stimulated in the periphery by systemic immunotherapies will be rendered inactive once entering this environment. Immunotherapies for prostate cancer need to br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53981ff67300109a4486688eeb84f677
https://doi.org/10.2147/itt.s257443

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EP.TU.226Removal of a pepper shaker from the rectum using a Foleys catheter, a novel technique of balloon trawling

Autor: Richard A. G. Smith, Aloka Suwanna Danwaththa Liyanage, Jacob Mewse

Publikováno v: British Journal of Surgery. 108

Background Foreign bodies inserted into the rectum often pose a challenge to the emergency surgical teams due to the unforthcoming nature surrounding the object inserted. Its shape, size and the position within the rectum and the associated bowel and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fedd6edb990b344cc3904d37226a3d5
https://doi.org/10.1093/bjs/znab311.031

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