Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Richard A D, Carano"'
Autor:
Anitha Priya Krishnan, Zhuang Song, David Clayton, Xiaoming Jia, Alex de Crespigny, Richard A. D. Carano
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract T2 lesion quantification plays a crucial role in monitoring disease progression and evaluating treatment response in multiple sclerosis (MS). We developed a 3D, multi-arm U-Net for T2 lesion segmentation, which was trained on a large, multic
Externí odkaz:
https://doaj.org/article/61222861b5b4417f977122a410927cd6
Autor:
Xiaoyong Wang, Skander Jemaa, Jill Fredrickson, Alexandre Fernandez Coimbra, Tina Nielsen, Alex De Crespigny, Thomas Bengtsson, Richard A. D. Carano
Publikováno v:
BMC Medical Imaging, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Purpose Positron emission tomography (PET)/ computed tomography (CT) has been extensively used to quantify metabolically active tumors in various oncology indications. However, FDG-PET/CT often encounters false positives in tumor detection d
Externí odkaz:
https://doaj.org/article/04aad2d3ad564c558ae667f831f4c02a
Autor:
WeiYu Lin, Daqi Xu, Cary D. Austin, Patrick Caplazi, Kate Senger, Yonglian Sun, Surinder Jeet, Judy Young, Donnie Delarosa, Eric Suto, Zhiyu Huang, Juan Zhang, Donghong Yan, Cesar Corzo, Kai Barck, Sharmila Rajan, Carrie Looney, Vineela Gandham, Justin Lesch, Wei-Ching Liang, Elaine Mai, Hai Ngu, Navneet Ratti, Yongmei Chen, Dinah Misner, Tori Lin, Dimitry Danilenko, Paula Katavolos, Estelle Doudemont, Hirdesh Uppal, Jeffrey Eastham, Judy Mak, Patricia E. de Almeida, Katherine Bao, Azadeh Hadadianpour, Mary Keir, Richard A. D. Carano, Lauri Diehl, Min Xu, Yan Wu, Robby M. Weimer, Jason DeVoss, Wyne P. Lee, Mercedesz Balazs, Kevin Walsh, Kathila R. Alatsis, Flavius Martin, Ali A. Zarrin
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central nervous system and sk
Externí odkaz:
https://doaj.org/article/f5bbd900f7f94b86b15fbd853c8ad352
Autor:
Anitha Priya Krishnan, Zhuang Song, David Clayton, Laura Gaetano, Xiaoming Jia, Alex de Crespigny, Thomas Bengtsson, Richard A. D. Carano
Publikováno v:
Radiology. 302:662-673
Background Deep learning-based segmentation could facilitate rapid and reproducible T1 lesion load assessments, which is crucial for disease management in multiple sclerosis (MS). T1 unenhancing and contrast-enhancing lesions in MS are those that enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5451371e5d1a3dbc4c1fd8ed5589856
https://doi.org/10.1148/radiol.211528
https://doi.org/10.1148/radiol.211528
Autor:
Ai-Luen Wu, Bo Feng, Mark Z Chen, Ganesh Kolumam, Jose Zavala-Solorio, Shelby K Wyatt, Vineela D Gandham, Richard A D Carano, Junichiro Sonoda
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57322 (2013)
The phosphaturic hormone Fibroblast Growth Factor 23 (FGF23) controls phosphate homeostasis by regulating renal expression of sodium-dependent phosphate co-transporters and cytochrome P450 enzymes involved in vitamin D catabolism. Multiple FGF Recept
Externí odkaz:
https://doaj.org/article/7746b2c7b71048fbbf201ac0ccb024f6
Autor:
Zhuang, Song, Anithapriya, Krishnan, Laura, Gaetano, Nicholas J, Tustison, David, Clayton, Alex, de Crespigny, Thomas, Bengtsson, Xiaoming, Jia, Richard A D, Carano
Publikováno v:
NeuroImage: Clinical. 34:102959
Despite advancements in treatments for multiple sclerosis, insidious disease progression remains an area of unmet medical need, for which atrophy-based biomarkers may help better characterize the progressive biology.We developed and applied a method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922b413e1f0cbba997a93c25df88d969
https://doi.org/10.1016/j.nicl.2022.102959
https://doi.org/10.1016/j.nicl.2022.102959
Autor:
Fredric Carlsson, Janice Kim, Calin Dumitru, Kai H Barck, Richard A D Carano, Mei Sun, Lauri Diehl, Eric J Brown
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000895 (2010)
The Esx-1 (type VII) secretion system is a major virulence determinant of pathogenic mycobacteria, including Mycobacterium marinum. However, the molecular events and host-pathogen interactions underlying Esx-1-mediated virulence in vivo remain unclea
Externí odkaz:
https://doaj.org/article/8ebb5063ee474f6f97c82e62750b4dee
Autor:
Yan Gong, Eric Bourhis, Cecilia Chiu, Scott Stawicki, Venita I DeAlmeida, Bob Y Liu, Khanhky Phamluong, Tim C Cao, Richard A D Carano, James A Ernst, Mark Solloway, Bonnee Rubinfeld, Rami N Hannoush, Yan Wu, Paul Polakis, Mike Costa
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12682 (2010)
β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3. The large number and se
Externí odkaz:
https://doaj.org/article/e5991f379a5147a2b9b70b45b9ce3556
Autor:
Yunzhou, Shi, Jason, Oeh, Anna, Hitz, Maj, Hedehus, Jeffrey, Eastham-Anderson, Franklin V, Peale, Patricia, Hamilton, Thomas, O'Brien, Deepak, Sampath, Richard A D, Carano
Publikováno v:
Neoplasia (New York, N.Y.)
The effect of anti-angiogenic agents on tumor oxygenation has been in question for a number of years, where both increases and decreases in tumor pO2 have been observed. This dichotomy in results may be explained by the role of vessel normalization i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a68fda7da544d36509d48c1d6e82f00
https://pubmed.ncbi.nlm.nih.gov/28987998
https://pubmed.ncbi.nlm.nih.gov/28987998
Autor:
Wendy B. Young, Karin Reif, Jed Ross, Jacqueline M. Tarrant, Donna M. Dambach, Karin Staflin, Adam R. Johnson, Arna Katewa, Rebecca Erickson, Maj Hedehus, Shelly Zhong, Sock-Cheng Lewin-Koh, Fiona Zhong, Lichuan Liu, Michelle McDowell, James J. Crawford, Dinah L. Misner, Richard A. D. Carano, Harvey Wong, Leah Schutt
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 360(1)
Bruton's tyrosine kinase (BTK) is a member of the Tec family of cytoplasmic tyrosine kinases involved in B-cell and myeloid cell signaling. Small molecule inhibitors of BTK are being investigated for treatment of several hematologic cancers and autoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c52d1f7eef877b23d6153cf3a1c3f8
https://pubmed.ncbi.nlm.nih.gov/27821712
https://pubmed.ncbi.nlm.nih.gov/27821712