Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Richard A Currie"'
Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues
Autor:
Simon Plummer, Bobby Beaumont, Matthew Elcombe, Stephanie Wallace, Jayne Wright, Elizabeth F Mcinnes, Richard A Currie, David Cowie
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 155-161 (2021)
Species differences in hepatic metabolism of thyroxine (T4) by uridine diphosphate glucuronosyl transferase (UGT) and susceptibility to thyroid hormone imbalance could underlie differences in thyroid carcinogenesis caused by hepatic enzyme inducers i
Externí odkaz:
https://doaj.org/article/df6e7a9cd963474aa45fe0574be13157
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008562 (2021)
Effective regulation of the sonic hedgehog (Shh) signalling pathway is essential for normal development in a wide variety of species. Correct Shh signalling requires the formation of Shh aggregates on the surface of producing cells. Shh aggregates su
Externí odkaz:
https://doaj.org/article/e37baa2b57d940aaaa1d13063c421df8
Autor:
Ann Sluder, Sheetal Shah, Jérôme Cassayre, Ralph Clover, Peter Maienfisch, Louis-Pierre Molleyres, Elizabeth A Hirst, Anthony J Flemming, Min Shi, Penny Cutler, Carole Stanger, Richard S Roberts, David J Hughes, Thomas Flury, Michael P Robinson, Elke Hillesheim, Thomas Pitterna, Fredrik Cederbaum, Paul A Worthington, Andrew J Crossthwaite, John D Windass, Richard A Currie, Fergus G P Earley
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e34712 (2012)
The efficacy of all major insecticide classes continues to be eroded by the development of resistance mediated, in part, by selection of alleles encoding insecticide insensitive target proteins. The discovery of new insecticide classes acting at nove
Externí odkaz:
https://doaj.org/article/01ae6528af6c47e98391b659caff9a2a
Autor:
Lauraine Y. Swindale, Alexander J. Stevens, Sarah J. Whalley, Richard A. Currie, K. Michael Jessop, Florence Lai, Pei Pei Lim, Elizabeth F. McInnes, David Cowie, Aniko Kende
Publikováno v:
Toxicology Letters. 380:62-68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e21c60f84d5a0dbcbdec8990ac736a09
https://doi.org/10.1016/j.toxlet.2023.03.009
https://doi.org/10.1016/j.toxlet.2023.03.009
Autor:
Douglas C Wolf, Yadvinder Bhuller, Rhian Cope, Marco Corvaro, Richard A Currie, John Doe, Adriana Doi, Gina Hilton, Jyotigna Mehta, David Saltmiras, Fiona Sewell, Maria Trainer, Sandrine E Déglin
Publikováno v:
Pest Management Science. 78:5049-5056
The present agrochemical safety evaluation paradigm is long-standing and anchored in well-established testing and evaluation procedures. However, it does not meet the present-day challenges of rapidly growing populations, food insecurity, and pressur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bad5534adbd98ba81d0e247b56ea0a0
https://doi.org/10.1002/ps.7148
https://doi.org/10.1002/ps.7148
Autor:
Douglas C. Wolf, Carol Beevers, Pratibha Mistry, Rejin Salimraj, Richard A. Currie, Elizabeth F. McInnes, Paul Parsons
Publikováno v:
Toxicology Letters. 351:18-27
The aim of this study was to examine whether short term, repeat dose, rat studies provide sufficient information about potential carcinogenicity to enable predictions about the carcinogenic potential of agrochemicals to be made earlier in compound de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd12fe9d081b024c4bc99a84a7446c8
https://doi.org/10.1016/j.toxlet.2021.08.003
https://doi.org/10.1016/j.toxlet.2021.08.003
Autor:
Kamin J Johnson, Scott S Auerbach, Tina Stevens, Tara S Barton-Maclaren, Eduardo Costa, Richard A Currie, Deidre Dalmas Wilk, Saddef Haq, Julia E Rager, Anthony J F Reardon, Leah Wehmas, Andrew Williams, Jason O’Brien, Carole Yauk, Jessica L LaRocca, Syril Pettit
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 190(2)
Use of molecular data in human and ecological health risk assessments of industrial chemicals and agrochemicals has been anticipated by the scientific community for many years; however, these data are rarely used for risk assessment. Here, a logic fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe1dc01b242e1f05ecdbcee43a16681
https://pubmed.ncbi.nlm.nih.gov/36165699
https://pubmed.ncbi.nlm.nih.gov/36165699
Publikováno v:
International Journal of Hospitality Management. 113:103513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4829b3377f39f0d751f058acd61e394c
https://doi.org/10.1016/j.ijhm.2023.103513
https://doi.org/10.1016/j.ijhm.2023.103513
Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues
Autor:
Elizabeth F. McInnes, Stephanie Wallace, David Cowie, Simon Plummer, Matthew Elcombe, Richard A. Currie, Bobby Beaumont, Jayne Wright
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 155-161 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • Species differences in UGT induction could mediate thyroid cancer susceptibility. • The effect of CAR activators on rat thyroid carcinogenesis could be partly explained by differential induction of Ugt 2b17.
Highlights • Species differences in UGT induction could mediate thyroid cancer susceptibility. • The effect of CAR activators on rat thyroid carcinogenesis could be partly explained by differential induction of Ugt 2b17.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14832b7cdf9942079952c6c70ad2ff80
https://doi.org/10.1016/j.toxrep.2020.12.019
https://doi.org/10.1016/j.toxrep.2020.12.019
Publikováno v:
The Wiley Encyclopedia of Personality and Individual Differences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ef55bca7fd13dfeb260c4aa2602f67
https://doi.org/10.1002/9781119547181.ch344
https://doi.org/10.1002/9781119547181.ch344