Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Richard A, Stanton"'
Autor:
Carly M. Bliss, Sarah L. Hulin-Curtis, Marta Williams, Mahulena Marušková, James A. Davies, Evelina Statkute, Alexander T. Baker, Louise Stack, Lucas Kerstetter, Lauren E. Kerr-Jones, Kate F. Milward, Gabrielle Russell, Sarah J. George, Luned M. Badder, Richard J. Stanton, Lynda Coughlan, Ian R. Humphreys, Alan L. Parker
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101308- (2024)
Adenoviruses (Ads) have demonstrated significant success as replication-deficient (RD) viral vectored vaccines, as well as broad potential across gene therapy and cancer therapy. Ad vectors transduce human cells via direct interactions between the vi
Externí odkaz:
https://doaj.org/article/2537722157ec439c93f92451f7495d20
Autor:
Pragati S. Amratia, Lauren E. Kerr-Jones, Lucy Chapman, Morgan Marsden, Mathew Clement, Richard J. Stanton, Ian R. Humphreys
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT There are no licensed vaccines for human cytomegalovirus (HCMV), and current antiviral drugs that target viral proteins are toxic and prone to resistance. Targeting host pathways essential for virus replication provides an alternate strategy
Externí odkaz:
https://doaj.org/article/613750e441714396a0e3f6c143066e65
Autor:
Debora Obergfäll, Markus Wild, Mona Sommerer, Malena Barillas Dahm, Jintawee Kicuntod, Julia Tillmanns, Melanie Kögler, Josephine Lösing, Kishore Dhotre, Regina Müller, Christina Wangen, Sabrina Wagner, Quang V. Phan, Lüder Wiebusch, Katarína Briestenská, Jela Mistríková, Lauren Kerr-Jones, Richard J. Stanton, Sebastian Voigt, Friedrich Hahn, Manfred Marschall
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1238 (2024)
Background. Cyclin-dependent kinase 8 (CDK8) is a multifaceted regulator and represents a catalytic component of the transcriptional Mediator complex. CDK8 activity, on the one hand, increases transcriptional elongation by the recruitment of Mediator
Externí odkaz:
https://doaj.org/article/50f7819660bd402ab81087a6f158cee0
Autor:
Carolyn Samer, Hamish E.G. McWilliam, Brian P. McSharry, Thilaga Velusamy, James G. Burchfield, Richard J. Stanton, David C. Tscharke, Jamie Rossjohn, Jose A. Villadangos, Allison Abendroth, Barry Slobedman
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108801- (2024)
Summary: The major histocompatibility complex (MHC), Class-I-related (MR1) molecule presents microbiome-synthesized metabolites to Mucosal-associated invariant T (MAIT) cells, present at sites of herpes simplex virus (HSV) infection. During HSV type
Externí odkaz:
https://doaj.org/article/6e9ab8496a94412f99c1c5df7b46f8e0
Autor:
Michael D. Grant, Kirsten Bentley, Ceri A. Fielding, Keeley M. Hatfield, Danielle P. Ings, Debbie Harnum, Eddie C.Y. Wang, Richard J. Stanton, Kayla A. Holder
Publikováno v:
JCI Insight, Vol 8, Iss 15 (2023)
Antibodies capable of neutralizing SARS-CoV-2 are well studied, but Fc receptor–dependent antibody activities that can also significantly impact the course of infection have not been studied in such depth. Since most SARS-CoV-2 vaccines induce only
Externí odkaz:
https://doaj.org/article/0873e35be2d54f0ba50c0cd65d8cac03
Autor:
Christopher Prestel, Heather Moulton-Meissner, Paige Gable, Richard A. Stanton, Janet Glowicz, Lauren Franco, Mary McConnell, Tiffany Torres, Dijo John, Gillian Blackwell, Renae Yates, Chavela Brown, Kristina Reyes, Gillian A. McAllister, Jasen Kunz, Erin E. Conners, Katharine M. Benedict, Amy Kirby, Mia Mattioli, Kerui Xu, Nicole Gualandi, Stephanie Booth, Shannon Novosad, Matthew Arduino, Alison Laufer Halpin, Katherine Wells, Maroya Spalding Walters
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 10, Pp 2069-2073 (2022)
During June 2017–November 2019, a total 36 patients with carbapenem-resistant Pseudomonas aeruginosa harboring Verona-integron–encoded metallo-β-lactamase were identified in a city in western Texas, USA. A faucet contaminated with the organism,
Externí odkaz:
https://doaj.org/article/1e6194ac249f4175aa3707d7e0ede189
Autor:
Martin J. Scurr, George Lippiatt, Lorenzo Capitani, Kirsten Bentley, Sarah N. Lauder, Kathryn Smart, Michelle S. Somerville, Tara Rees, Richard J. Stanton, Awen Gallimore, James P. Hindley, Andrew Godkin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The presence of SARS-CoV-2-specific antibodies alone is not an accurate determinant of immunity. In this work, the authors investigate if whole-blood based measurement of SARS-CoV-2 specific T cell responses could prognosticate the risk of possible S
Externí odkaz:
https://doaj.org/article/d478f34a0e4948beb39a42e0ae302a63
Autor:
Eleanor C. Semmes, Itzayana G. Miller, Nicole Rodgers, Caroline T. Phan, Jillian H. Hurst, Kyle M. Walsh, Richard J. Stanton, Justin Pollara, Sallie R. Permar
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Human cytomegalovirus (HCMV) is the most common vertically transmitted infection worldwide, yet there are no vaccines or therapeutics to prevent congenital HCMV (cCMV) infection. Emerging evidence indicates that antibody Fc effector functions may be
Externí odkaz:
https://doaj.org/article/6d94c2e943184ed78e63370ba002982d
Autor:
Rhys T. Meredith, Max D. Bermingham, Kirsten Bentley, Sayeh Agah, Abigail Aboagye-Odei, Ross A. R. Yarham, Hayley Mills, Muddassir Shaikh, Neil Hoye, Richard J. Stanton, David R. Chadwick, Maria A. Oliver
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionThe heterogeneity of the immunocompromised population means some individuals may exhibit variable, weak or reduced vaccine-induced immune responses, leaving them poorly protected from COVID-19 disease despite receiving multiple SARS-CoV-2
Externí odkaz:
https://doaj.org/article/66b536c9f70d4b08b5165d90765998a7
Autor:
Ian Kracalik, D. Cal Ham, Gillian McAllister, Amanda R. Smith, Maureen Vowles, Kelly Kauber, Melba Zambrano, Gretchen Rodriguez, Kelley Garner, Kaitlyn Chorbi, P. Maureen Cassidy, Shannon McBee, Rhett J. Stoney, Kathleen Moser, Margarita E. Villarino, Oscar E. Zazueta, Amelia Bhatnagar, Erisa Sula, Richard A. Stanton, Allison C. Brown, Alison L. Halpin, Lauren Epstein, Maroya Spalding Walters
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 1, Pp 51-61 (2022)
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) producing the Verona integron‒encoded metallo-β-lactamase (VIM) are highly antimicrobial drug-resistant pathogens that are uncommon in the United States. We investigated the source of VIM-CRPA amo
Externí odkaz:
https://doaj.org/article/dcdcf12a2085484fb1864ce967b2ff3a