Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Richard A, Sidner"'
Autor:
Zheng-Yu Wang, James R. Butler, Devin E. Eckhoff, Joseph M. Ladowski, Clarkson Smith, Luz M. Reyes, Joseph Tector, Juliet L. Easlick, Jose Estrada, Gregory R. Martens, Matthew Tector, Richard A. Sidner
Publikováno v:
Transplantation. 103:1620-1629
Background Highly sensitized patients are difficult to match with suitable renal allograft donors and may benefit from xenotransplant trials. We evaluate antibody binding from sensitized patients to pig cells and engineered single allele cells to ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f285aab2744529c0c61df269ae4a6d5c
https://doi.org/10.1097/tp.0000000000002739
https://doi.org/10.1097/tp.0000000000002739
Autor:
Matthew Tector, Gregory R. Martens, Leela L. Paris, James R. Butler, Ping Li, Ross L. Blankenship, Richard A. Sidner, Jose L. Estrada, A. Joseph Tector, Joseph M. Ladowski
Publikováno v:
Transplantation. 100:571-576
A profound thrombocytopenia limits hepatic xenotransplantation in the pig-to-primate model. Porcine livers also have shown the ability to phagocytose human platelets in the absence of immune-mediated injury. Recently, inactivation of the porcine ASGR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdd7c11fa91ba22eeb3bbeadb2eee85
https://doi.org/10.1097/tp.0000000000001071
https://doi.org/10.1097/tp.0000000000001071
Autor:
Gregory R, Martens, Luz M, Reyes, Ping, Li, James R, Butler, Joseph M, Ladowski, Jose L, Estrada, Richard A, Sidner, Devin E, Eckhoff, Matt, Tector, A Joseph, Tector
Publikováno v:
Transplantation
Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA).Peripheral blood mononuclear cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091269da14b7dec08ca6e05b4917fca6
https://pubmed.ncbi.nlm.nih.gov/29381648
https://pubmed.ncbi.nlm.nih.gov/29381648
Autor:
A. Joseph Tector, Bess Ivary, Leela L. Paris, Luz M. Reyes, Jose L. Estrada, Richard A. Sidner
Publikováno v:
Journal of Surgical Research. 184:e37-e42
Background The process of selecting transgenic cells has been one of the bottlenecks in the generation of transgenic animals by somatic cell nuclear transfer (SCNT). In particular, selection for the Gal double-knockout (Gal-DKO) genotype has been tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5849ce8a41b4fbcbc6611afa3b014b92
https://doi.org/10.1016/j.jss.2012.11.054
https://doi.org/10.1016/j.jss.2012.11.054
Autor:
Andrew J. Lutz, Alex T. Heyrman, Zheng Yu Wang, Christopher Burlak, A. Joseph Tector, Susan M. Downey, Richard A. Sidner, Ray K. Chihara, Leela L. Paris
Publikováno v:
Journal of Surgical Research. 184:1123-1133
Background Antibody-mediated rejection continues to be an obstacle for xenotransplantation despite development of α1,3-galactosyltransferase knockout (GTKO) pigs. Fibronectin (Fn) from GTKO pigs was identified as a xenoantigen in baboons. N-glycolyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8afe2b35070e101ec52e274a07cd8f
https://doi.org/10.1016/j.jss.2013.04.012
https://doi.org/10.1016/j.jss.2013.04.012
Autor:
Richard A. Sidner, Ross L. Blankenship, A. Joseph Tector, Zheng Yu Wang, Ping Li, Gregory R. Martens, Matthew Tector, Jose L. Estrada
Publikováno v:
Transplantation. 101(3)
Background The rapidly improving tools of genetic engineering may make it possible to overcome the humoral immune barrier that prevents xenotransplantation. We hypothesize that levels of human antibody binding to donor tissues from swine must approxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edafd67a3c900ceb55319ba6c9f2353
https://pubmed.ncbi.nlm.nih.gov/27379553
https://pubmed.ncbi.nlm.nih.gov/27379553
Publikováno v:
Xenotransplantation. 19:31-39
Acute thrombocytopenia observed during liverxenotransplantation is mediated partially by liversinusoidal cells. Both the asialoglycoprotein recep-tor-1 (ASGR1) and macrophage antigen complex-1 (Mac-1) participate in this process as knockdownof these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::857580db5fdfdcfcb4d4980c67afddc3
https://doi.org/10.1111/j.1399-3089.2011.00685.x
https://doi.org/10.1111/j.1399-3089.2011.00685.x
Publikováno v:
Journal of Biomedical Science and Engineering. :263-269
Water-soluble polymers poly(ethylene glycol) (PEG) and poly(N-vinylpyrrolidone) (PVP) were used to study cryopreservation of porcine islets. DMSO was used as control. The effects of polymer purity, molecular weight (MW) and concentration on islet via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dee5326d8e7695260f0fdb5c79fc32a
https://doi.org/10.4236/jbise.2012.55033
https://doi.org/10.4236/jbise.2012.55033
Autor:
Richard A. Sidner, Susan M. Downey, Christopher Burlak, A. Joseph Tector, Ray K. Chihara, Luz M. Reyes, Leela L. Paris
Publikováno v:
Xenotransplantation. 17:350-361
Burlak C, Paris LL, Chihara RK, Sidner RA, Reyes LM, Downey SM, Tector AJ. The fate of human platelets perfused through the pig liver: implications for xenotransplantation. Xenotransplantation 2010; 17: 350–361. © 2010 John Wiley & Sons A/S. Abstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11034c983e344876c642f16337d2ff2f
https://doi.org/10.1111/j.1399-3089.2010.00605.x
https://doi.org/10.1111/j.1399-3089.2010.00605.x
Autor:
Mandy L. Ford, Ping Li, Greg Martens, Kenneth A. Newell, Richard A. Sidner, Matthew Tector, Jose L. Estrada, Andrew B. Adams, James R. Butler, Joseph Tector
Publikováno v:
Xenotransplantation. 22(3)
Background Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4GalNT2 glycosyltransferase may also synthesize xenoantigens. To further characterize glycan-based species inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef847b29f2f427fed6ea2b9e7d96704
https://pubmed.ncbi.nlm.nih.gov/25728481
https://pubmed.ncbi.nlm.nih.gov/25728481