Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer’s disease

Autor: Christopher D. Whelan, Niklas Mattsson, Michael W. Nagle, Swetha Vijayaraghavan, Craig Hyde, Shorena Janelidze, Erik Stomrud, Julie Lee, Lori Fitz, Tarek A. Samad, Gayathri Ramaswamy, Richard A. Margolin, Anders Malarstig, Oskar Hansson

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-14 (2019)

Abstract To date, the development of disease-modifying therapies for Alzheimer’s disease (AD) has largely focused on the removal of amyloid beta Aβ fragments from the CNS. Proteomic profiling of patient fluids may help identify novel therapeutic t

Externí odkaz: https://doaj.org/article/d2b5bbd9197e4ce8a2ccfd4b15b135e3

IN‐VIVO EVALUATION OF APN‐1808, A TAU SMALL MOLECULE THERAPEUTIC

Autor: Paul Tempest, Yih‐Shyan Lin, Yen‐Ting Lai, Chin‐Yin Tai, Haou‐Tzong Ma, Sheng‐Chieh Huang, Richard A Margolin, Chia‐Lin Wu, Ming‐Kuei Jang

Publikováno v: Alzheimer's & Dementia. 18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8fbd268cc071ab9b686054a8aa2c959
https://doi.org/10.1002/alz.062995

The APP intracellular domain promotes

Autor: Zhi-Wei, Zhang, Haitao, Tu, Mei, Jiang, Sarivin, Vanan, Sook Yoong, Chia, Se-Eun, Jang, Wuan-Ting, Saw, Zhi-Wei, Ong, Dong-Rui, Ma, Zhi-Dong, Zhou, Jie, Xu, Kai-Hua, Guo, Wei-Ping, Yu, Shuo-Chien, Ling, Richard A, Margolin, Daniel G, Chain, Li, Zeng, Eng-King, Tan

Publikováno v: Science signaling. 15(748)

Gain-of-function mutations in the leucine-rich repeat kinase 2 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a63e5fba0092140ba19a72457efecdd2
https://pubmed.ncbi.nlm.nih.gov/35998231

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

Autor: David Miller, Niklas Mattsson, Lisa J. Bain, Julie A. Schneider, David S. Knopman, Maria C. Carrillo, Hartmuth C. Kolb, Clifford R. Jack, Maria B. Tome, David L. Sultzer, Eric Siemers, Megan Zoschg Canniere, Ronald C. Petersen, Samantha Budd Haeberlein, Argonde C. van Harten, Susan M. Resnick, Richard A. Margolin, Peter T. Nelson, Paul Maruff, Prashanthi Vemuri, Gary Romano, Thomas J. Montine, Mary Sano, James Hendrix, Gary Tong, David A. Wolk, Melissa E. Murray, Geoff Kerchner

Publikováno v: Knopman, D S, Haeberlein, S B, Carrillo, M C, Hendrix, J A, Kerchner, G, Margolin, R, Maruff, P, Miller, D S, Tong, G, Tome, M B, Murray, M E, Nelson, P T, Sano, M, Mattsson, N, Sultzer, D L, Montine, T J, Jack, C R, Kolb, H, Petersen, R C, Vemuri, P, Canniere, M Z, Schneider, J A, Resnick, S M, Romano, G, van Harten, A C, Wolk, D A, Bain, L J & Siemers, E 2018, ' The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable ', Alzheimer's and Dementia, vol. 14, no. 4, pp. 563-575 . https://doi.org/10.1016/j.jalz.2018.03.002
Alzheimer's and Dementia, 14(4), 563-575. Elsevier

The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98cb075f4fdeaccd076b4a16c739811
https://doi.org/10.1016/j.jalz.2018.03.002

Technical Note. Effect of Geometrical Distortion Correction in MR on Image Registration Accuracy

Autor: J.M. Fitzpatrick, Calvin R. Maurer, Robert J. Maciunas, Georges B. Aboutanos, Benoit M. Dawant, Richard A. Margolin, S. Gadamsetty

Publikováno v: Journal of Computer Assisted Tomography. 20:666-679

In this article we investigate the effect of geometrical distortion correction in MR images on the accuracy of the registration of X-ray CT and MR head images for both a fiducial marker (extrinsic point) method and a surface-matching technique. We us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c689d0c7a3e35c1c566c03c0a5597529
https://doi.org/10.1097/00004728-199607000-00032