Zobrazeno 1 - 10
of 325
pro vyhledávání: '"Richard A, Lang"'
MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ
Autor:
Sandra Schrenk, Lindsay J. Bischoff, Jillian Goines, Yuqi Cai, Shruti Vemaraju, Yoshinobu Odaka, Samantha R. Good, Joseph S. Palumbo, Sara Szabo, Damien Reynaud, Catherine D. Van Raamsdonk, Richard A. Lang, Elisa Boscolo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Life-threatening vascular tumors can be associated with uncontrolled activity of the guanine nucleotide-binding protein subunit alpha (Gαq). Here, the authors develop a murine model for these tumors and show that MEK inhibition prevents formation of
Externí odkaz:
https://doaj.org/article/7cad600490c342d6b140a087bcb306ca
Autor:
Heather A. McCauley, Anne Marie Riedman, Jacob R. Enriquez, Xinghao Zhang, Miki Watanabe-Chailland, J. Guillermo Sanchez, Daniel O. Kechele, Emily F. Paul, Kayle Riley, Courtney Burger, Richard A. Lang, James M. Wells
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 6, Pp 1293-1310 (2023)
Background & Aims: The intestinal stem cell niche is exquisitely sensitive to changes in diet, with high-fat diet, caloric restriction, and fasting resulting in altered crypt metabolism and intestinal stem cell function. Unlike cells on the villus, c
Externí odkaz:
https://doaj.org/article/1572cbb0e6804874852f6a419b62b436
Autor:
Vijay K. Jidigam, Onkar B. Sawant, Rebecca D. Fuller, Kenya Wilcots, Rupesh Singh, Richard A. Lang, Sujata Rao
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Silencing of the retinal clock through targeting neuronal Bmal1 could constitute an approach to treating some forms of retinopathy.
Externí odkaz:
https://doaj.org/article/b2b6caf643d54dab8b68754e971879bb
Autor:
L Sofia Gonzalez, Austen A Fisher, Shane P D'Souza, Evelin M Cotella, Richard A Lang, J Elliott Robinson
Publikováno v:
eLife, Vol 12 (2023)
The mesolimbic dopamine system is an evolutionarily conserved set of brain circuits that play a role in attention, appetitive behavior, and reward processing. In this circuitry, ascending dopaminergic projections from the ventral midbrain innervate t
Externí odkaz:
https://doaj.org/article/c4784286b5fb47c89101599ce5c7b2e8
Autor:
Kevin D Gaitonde, Mutahar Andrabi, Courtney A Burger, Shane P D'Souza, Shruti Vemaraju, Bala S C Koritala, David F Smith, Richard A Lang
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0284824 (2023)
Neurons in the hypothalamic preoptic area (POA) regulate multiple homeostatic processes, including thermoregulation and sleep, by sensing afferent input and modulating sympathetic nervous system output. The POA has an autonomous circadian clock and m
Externí odkaz:
https://doaj.org/article/e4a0cabfd26a471dbef009bf7ccd1080
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Mammals maintain their internal body temperature within a physiologically optimal range. This involves the regulation of core body temperature in response to changing environmental temperatures and a natural circadian oscillation of internal temperat
Externí odkaz:
https://doaj.org/article/a10c255f1b0b460c8d713cba72631655
Autor:
William Dan, Ga Hyun Park, Shruti Vemaraju, Amy D. Wu, Kristina Perez, Meenakshi Rao, Dan E. Berkowitz, Richard A. Lang, Peter D. Yim
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Opsin photoreceptors outside of the central nervous system have been shown to mediate smooth muscle photorelaxation in several organs. We hypothesized that opsin receptor activation in the colon would have a similar effect and influence colonic motil
Externí odkaz:
https://doaj.org/article/6155128bb5524ca9a84bcd0c37947c4c
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The preoptic area of the hypothalamus is a homeostatic control center. The heterogeneous neurons in this nucleus function to regulate the sleep/wake cycle, reproduction, thirst and hydration, as well as thermogenesis and other metabolic responses. Se
Externí odkaz:
https://doaj.org/article/aacabb84664c404cbc0cbfab36eba0e2
Autor:
Prathamesh T. Nadar-Ponniah, Shahar Taiber, Michal Caspi, Tal Koffler-Brill, Amiel A. Dror, Ronen Siman-Tov, Moran Rubinstein, Krishnanand Padmanabhan, Chen Luxenburg, Richard A. Lang, Karen B. Avraham, Rina Rosin-Arbesfeld
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Striatin, a subunit of the serine/threonine phosphatase PP2A, is a core member of the conserved striatin-interacting phosphatase and kinase (STRIPAK) complexes. The protein is expressed in the cell junctions between epithelial cells, which play a rol
Externí odkaz:
https://doaj.org/article/65ad499baa77461c8186105fde3350ae
Autor:
Gowri Nayak, Kevin X. Zhang, Shruti Vemaraju, Yoshinobu Odaka, Ethan D. Buhr, Amanda Holt-Jones, Stace Kernodle, April N. Smith, Brian A. Upton, Shane D’Souza, Jesse J. Zhan, Nicolás Diaz, Minh-Thanh Nguyen, Rajib Mukherjee, Shannon A. Gordon, Gang Wu, Robert Schmidt, Xue Mei, Nathan T. Petts, Matthew Batie, Sujata Rao, John B. Hogenesch, Takahisa Nakamura, Alison Sweeney, Randy J. Seeley, Russell N. Van Gelder, Joan Sanchez-Gurmaches, Richard A. Lang
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 672-686.e8 (2020)
Summary: Almost all life forms can detect and decode light information for adaptive advantage. Examples include the visual system, in which photoreceptor signals are processed into virtual images, and the circadian system, in which light entrains a p
Externí odkaz:
https://doaj.org/article/f3d3889d1421467786d668b9cc43654f