Zobrazeno 1 - 10
of 698
pro vyhledávání: '"Richard A, Gardner"'
Autor:
Nicholas T. Ventham, Nicholas A. Kennedy, Rahul Kalla, Alex T. Adams, Alexandra Noble, Holly Ennis, Craig Mowat, Malcolm G. Dunlop, Jack Satsangi, Ian Arnott, Aiden Cahill, Malcolm Smith, Tariq Ahmad, Sreedhar Subramanian, Simon Travis, John Morris, John Hamlin, Anjan Dhar, Chuka Nwokolo, Cathryn Edwards, Tom Creed, Stuart Bloom, Mohamed Yousif, Linzi Thomas, Simon Campbell, Stephen J. Lewis, Shaji Sebastian, Sandip Sen, Simon Lal, Chris Hawkey, Charles Murray, Fraser Cummings, Jason Goh, James O. Lindsay, Naila Arebi, Lindsay Potts, Aileen J. McKinley, John M. Thomson, John A. Todd, Mhairi Collie, Ashley Mowat, Daniel R. Gaya, Jack Winter, Graham D. Naismith, Catriona Keerie, Steff Lewis, Robin J. Prescott, Gordan Lauc, Harry Campbell, Dermot P.B. McGovern, Vito Annese, Vlatka Zoldoš, Iain K. Permberton, Manfred Wuhrer, Daniel Kolarich, Daryl L. Fernandes, Evropi Theorodorou, Victoria Merrick Daniel I. Spencer, Richard A. Gardner, Ray Doran, Archana Shubhakar, Ray Boyapati, Igor Rudan, Paolo Lionetti, Irena Trbojević Akmačić, Jasminka Krištić, Frano Vuč ković, Jerko Štambuk, Mislav Novokmet, Maja Pučić-Baković, Olga Gornik, Angelo Andriulli, Laura Cantoro, Giancarlo Sturniolo, Gionata Fiorino, Natalia Manetti, Anna Latiano, Anna Kohn, Renata D’Inca`, Silvio Danese, Ian D. Arnott, Colin L. Noble, Charlie W. Lees, Alan G. Shand, Gwo-Tzer Ho, Lee Murphy, Jude Gibson, Louise Evenden, Nicola Wrobel, Tamara Gilchrist, Angie Fawkes, Guinevere S.M. Kammeijer, Florent Clerc, Noortje de Haan, Aleksandar Vojta, Ivana Samaržija, Dora Markulin, Marija Klasić, Paula Dobrinić, Yurii Aulchenko, Tim van den Heuve, Daisy Jonkers, Marieke Pierik
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 431-450 (2023)
Background & Aims: DNA methylation alterations may provide important insights into gene-environment interaction in cancer, aging, and complex diseases, such as inflammatory bowel disease (IBD). We aim first to determine whether the circulating DNA me
Externí odkaz:
https://doaj.org/article/f32b67ecfa854c6487a3c5196a5070e3
Autor:
Bayan Mashahreh, Shir Armony, Kristoffer Enøe Johansson, Alon Chappleboim, Nir Friedman, Richard G. Gardner, Rasmus Hartmann-Petersen, Kresten Lindorff-Larsen, Tommer Ravid
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
How misfolded proteins are selected by the ubiquitin-conjugating system for elimination is largely unknown. Here, the authors identify conserved features of proteome-derived degradation signals, including amino acid and structural preferences, that t
Externí odkaz:
https://doaj.org/article/cf7027894a32433c80084976497c6a94
Autor:
Róisín O’Flaherty, Manuela Amez Martín, Richard A. Gardner, Patrick M. Jennings, Pauline M. Rudd, Daniel I. R. Spencer, David Falck
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 125 (2024)
Recombinant human erythropoietin (EPO) is a biopharmaceutical frequently used in the treatment of anemia. It is a heavily glycosylated protein with a diverse and complex glycome. EPO N-glycosylation influences important pharmacological parameters, pr
Externí odkaz:
https://doaj.org/article/7761628facb24ab8a1a57ca707d15dcd
Autor:
Soracha E. Ward, Jamie M. O’Sullivan, Alan B. Moran, Daniel I. R. Spencer, Richard A. Gardner, Jyotika Sharma, Judicael Fazavana, Marco Monopoli, Thomas A.J. McKinnon, Alain Chion, Sandra Haberichter, James S. O’Donnell
Publikováno v:
Haematologica, Vol 107, Iss 3 (2021)
Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we showed that MGL influences phys
Externí odkaz:
https://doaj.org/article/df84523d82df4f9a98f0024a5a9002a7
Autor:
Radoslaw P Kozak, Karina Mondragon-Shem, Christopher Williams, Clair Rose, Samirah Perally, Guy Caljon, Jan Van Den Abbeele, Katherine Wongtrakul-Kish, Richard A Gardner, Daniel Spencer, Michael J Lehane, Álvaro Acosta-Serrano
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009071 (2021)
African sleeping sickness is caused by Trypanosoma brucei, a parasite transmitted by the bite of a tsetse fly. Trypanosome infection induces a severe transcriptional downregulation of tsetse genes encoding for salivary proteins, which reduces its ant
Externí odkaz:
https://doaj.org/article/480054e28b21411f9d3a04c5a6f10ac0
Autor:
Osmond D. Rebello, Simone Nicolardi, Guinevere S. M. Lageveen-Kammeijer, Jan Nouta, Richard A. Gardner, Wilma E. Mesker, Rob A. E. M. Tollenaar, Daniel I. R. Spencer, Manfred Wuhrer, David Falck
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Changes in the abundance of antennary fucosylated glycans in human total plasma N-glycome (TPNG) have been associated with several diseases ranging from diabetes to various forms of cancer. However, it is challenging to address this important part of
Externí odkaz:
https://doaj.org/article/c9868befe20045b0aee993d56e6de65e
Autor:
Kyle M. Griffith, Liisa Charie Hammer, Nicholas P. Iannuzzi, Karen C. Takatani, Jason Edward Hsu, James D. Cotton, Albert O. Gee, Richard J. Gardner, William D. Lack
Publikováno v:
Journal of Shoulder and Elbow Surgery. 31:2671-2677
Repetitive stress injuries to the rotator cuff, and particularly the supraspinatus tendon (SST), are highly prevalent and debilitating. These injuries typically occur through the application of cyclic load below the threshold necessary to cause acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d74560e7e3acd7b070d9036a5749bee
https://doi.org/10.1016/j.jse.2022.06.017
https://doi.org/10.1016/j.jse.2022.06.017
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1619 (2021)
Cellular homeostasis depends on robust protein quality control (PQC) pathways that discern misfolded proteins from functional ones in the cell. One major branch of PQC involves the controlled degradation of misfolded proteins by the ubiquitin-proteas
Externí odkaz:
https://doaj.org/article/84c914f5f0ea47cb9945cc10aa9a52e0
Autor:
Shasha Li, Alex J. McCraw, Richard A. Gardner, Daniel I.R. Spencer, Sophia N. Karagiannis, Gerd K. Wagner
Publikováno v:
Antibodies, Vol 10, Iss 4, p 44 (2021)
Monoclonal antibodies (mAbs) are one of the cornerstones of modern medicine, across an increasing range of therapeutic areas. All therapeutic mAbs are glycoproteins, i.e., their polypeptide chain is decorated with glycans, oligosaccharides of extraor
Externí odkaz:
https://doaj.org/article/71f03380c6464dcdaaea28f7180c4235
The dramatic increase in the number of child-custody disputes since the seventies has created an equally dramatic need for a standard reference work that examines the growing social problem of children who develop an irrational hatred for a parent as
