Zobrazeno 1 - 10
of 374
pro vyhledávání: '"Richard A, Cerione"'
Autor:
Cody Aplin, Kara A. Zielinski, Suzette Pabit, Deborah Ogunribido, William P. Katt, Lois Pollack, Richard A. Cerione, Shawn K. Milano
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Transglutaminase 2 (TG2) is a GTP-binding, protein-crosslinking enzyme that has been investigated as a therapeutic target for Celiac disease, neurological disorders, and aggressive cancers. TG2 has been suggested to adopt two conformational
Externí odkaz:
https://doaj.org/article/c30285b37bdd4cb1aa637ea1b450312e
Autor:
Elena Panizza, Richard A. Cerione
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Alzheimer’s disease (AD) is the leading neurodegenerative pathology in aged individuals, but many questions remain on its pathogenesis, and a cure is still not available. Recent research efforts have generated measurements of multiple omics in indi
Externí odkaz:
https://doaj.org/article/8496a171be5a4a59ba03f7f8e1bf4825
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The glutaminase enzymes GAC and GLS2 catalyze the hydrolysis of glutamine to glutamate, satisfying the ‘glutamine addiction’ of cancer cells. They are the targets of anti-cancer drugs; however, their mechanisms of activation and catalyti
Externí odkaz:
https://doaj.org/article/0e74d97efe8c4ed9bbc126d24beb796e
Autor:
Kara A. Zielinski, Andrea M. Katz, George D. Calvey, Suzette A. Pabit, Shawn K. Milano, Cody Aplin, Josue San Emeterio, Richard A. Cerione, Lois Pollack
Publikováno v:
IUCrJ, Vol 10, Iss 3, Pp 363-375 (2023)
Advances in time-resolved structural techniques, mainly in macromolecular crystallography and small-angle X-ray scattering (SAXS), allow for a detailed view of the dynamics of biological macromolecules and reactions between binding partners. Of parti
Externí odkaz:
https://doaj.org/article/845924a548ac481394f8df26f15ff8be
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Proliferating cancer cells are dependent on glutamine metabolism for survival when challenged with oxidative stresses caused by reactive oxygen species, hypoxia, nutrient deprivation and matrix detachment. ATF4, a key stress responsive trans
Externí odkaz:
https://doaj.org/article/2b6e395476e8442b88f80188b99b4086
Autor:
Samantha C Schwager, Katherine M Young, Lauren A Hapach, Caroline M Carlson, Jenna A Mosier, Tanner J McArdle, Wenjun Wang, Curtis Schunk, Anissa L Jayathilake, Madison E Bates, Francois Bordeleau, Marc A Antonyak, Richard A Cerione, Cynthia A Reinhart-King
Publikováno v:
eLife, Vol 11 (2022)
Cancer cell migration is highly heterogeneous, and the migratory capability of cancer cells is thought to be an indicator of metastatic potential. It is becoming clear that a cancer cell does not have to be inherently migratory to metastasize, with w
Externí odkaz:
https://doaj.org/article/622c88bf6fa14684a1a8c69fe64f0098
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100295- (2021)
Summary: Cells produce two broad classes of extracellular vesicles (EVs), exosomes and microvesicles (MVs). Exosomes are 30–150 nm vesicles derived from multivesicular bodies, while MVs are 200–1,000 nm vesicles that pinch off from plasma membran
Externí odkaz:
https://doaj.org/article/e2c6f6813597462091f5771819700f3b
Autor:
Jing Wang, Xiangjin Zhuang, Kai Su Greene, Ha Si, Marc A. Antonyak, Joseph E. Druso, Kristin F. Wilson, Richard A. Cerione, Qiyu Feng, Hongyang Wang
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 3, Pp n/a-n/a (2021)
Abstract Tumour‐derived microvesicles (MVs) serve as critical mediators of cell‐to‐cell communication in the tumour microenvironment. So far, the underlying mechanisms of MV biogenesis, especially how key tumorigenesis signals such as abnormal
Externí odkaz:
https://doaj.org/article/36e51596f90143b495d624b14b09205f
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 3 (2020)
The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status. We describe how glutaminase (GLS) is destab
Externí odkaz:
https://doaj.org/article/0b1f4eac2a34411eb6e4e08a91e8e017
Autor:
Alain Ibáñez de Opakua, Kshitij Parag-Sharma, Vincent DiGiacomo, Nekane Merino, Anthony Leyme, Arthur Marivin, Maider Villate, Lien T. Nguyen, Miguel Angel de la Cruz-Morcillo, Juan B. Blanco-Canosa, Sekar Ramachandran, George S. Baillie, Richard A. Cerione, Francisco J. Blanco, Mikel Garcia-Marcos
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nonreceptor guanine-nucleotide exchange factors (GEFs) are emerging as important regulators of heterotrimeric G proteins. Here, the authors present structural and mechanistic insights into how a class of nonreceptor GEFs containing the Ga-Binding and
Externí odkaz:
https://doaj.org/article/66ed9d678b9b4909beb7dc11e3606d2b