Zobrazeno 1 - 10
of 251
pro vyhledávání: '"Richard A, Bunce"'
Publikováno v:
Molecules, Vol 29, Iss 18, p 4322 (2024)
A synthesis of benzo[d]oxazoles by an N-deprotonation–O-SNAr cyclization sequence from anilide precursors is reported. Anilides derived from 2-fluorobenzaldehydes, activated toward SNAr ring closure by C5 electron-withdrawing groups, were prepared
Externí odkaz:
https://doaj.org/article/fb745a45552646928371123b377ce767
Publikováno v:
Molecules, Vol 29, Iss 14, p 3406 (2024)
A one-pot [3+3] aldol-SNAr-dehydration annulation sequence was utilized to fuse hindered phenols onto aromatic substrates. The transformation joins doubly activated 1,3-disubstituted acetone derivatives (dinucleophiles) with C5-activated 2-fluorobenz
Externí odkaz:
https://doaj.org/article/9588f2d2a91c486982656f405c87858f
Autor:
Baskar Nammalwar, Richard A. Bunce
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 104 (2024)
Pyrimidines have become an increasingly important core structure in many drug molecules over the past 60 years. This article surveys recent areas in which pyrimidines have had a major impact in drug discovery therapeutics, including anti-infectives,
Externí odkaz:
https://doaj.org/article/5faf240f1a614e848104b5a7586ee217
Autor:
Dylan R. Nanney, Richard A. Bunce
Publikováno v:
Molbank, Vol 2022, Iss 4, p M1526 (2022)
A synthesis of the title compound and related structures is reported. The procedure involves double alkylation of a β-ketoester followed by double SNAr ring closure from the γ carbon to give a dibenzo[3.3.1]bicyclic unit. This paper appears to be t
Externí odkaz:
https://doaj.org/article/242995059ff94f6b8400196f9c46d29c
Publikováno v:
Molecules, Vol 28, Iss 15, p 5856 (2023)
A domino aldol-SNAr-dehydration [3+3] annulation strategy has been utilized to fuse six-membered cyclic amides onto aromatic substrates. 2-Arylacetamides have been reacted with 2-fluorobenzaldehyde derivatives activated toward SNAr reaction by an ele
Externí odkaz:
https://doaj.org/article/770ba6d49ce54e82a4e4d16a8849e1bd
Publikováno v:
Molecules, Vol 28, Iss 7, p 3256 (2023)
A series of new Morita–Baylis–Hillman acetates were prepared and reacted with methanesulfonamide (K2CO3, DMF, 23 °C) to produce tertiary dihydroquinoline sulfonamides in high yields. Subsequent efforts to eliminate the methylsulfonyl group from
Externí odkaz:
https://doaj.org/article/7ab055f8f79b4fccab04845c1b5fb870
Publikováno v:
Molecules, Vol 27, Iss 20, p 6998 (2022)
A new synthesis of C5-substituted 1-alkyl-1H-indole-3-carboxylic esters is reported. A series of methyl 2-arylacrylate aza-Michael acceptors were prepared with aromatic substitution to activate them towards SNAr reaction. Subsequent reaction with a s
Externí odkaz:
https://doaj.org/article/99cbc276fd4b42409f306ee48c031ec0
Autor:
Kwabena Fobi, Richard A. Bunce
Publikováno v:
Molecules, Vol 27, Iss 13, p 4123 (2022)
The Friedländer synthesis offers efficient access to substituted quinolines from 2-aminobenzaldehydes and activated ketones in the presence of a base. The disadvantage of this procedure lies in the fact that relatively few 2-aminobenzaldehyde deriva
Externí odkaz:
https://doaj.org/article/8cae00f831d34f65a76b9944c824994b
Autor:
Barry K. Lavine, Necati Kaval, Leah Oxenford, Mariya Kim, Kaushalya Sharma Dahal, Nuwan Perera, Rudolf Seitz, James T. Moulton, Richard A. Bunce
Publikováno v:
Sensors, Vol 21, Iss 19, p 6493 (2021)
Swellable polymer microspheres that respond to pH were prepared by free radical dispersion polymerization using N-isopropylacrylamide (NIPA), N,N′-methylenebisacrylamide (MBA), 2,2-dimethoxy-2-phenylacetylphenone, N-tert-butylacrylamide (NTBA), and
Externí odkaz:
https://doaj.org/article/27e877a313074370a81496ba05799712
Publikováno v:
Molecules, Vol 26, Iss 4, p 890 (2021)
An efficient synthetic route to highly substituted dihydroquinolines and dihydronaphthyridines has been developed using a domino reaction of Morita-Baylis-Hillman (MBH) acetates with primary aliphatic and aromatic amines in DMF at 50–90 °C. The MB
Externí odkaz:
https://doaj.org/article/709ff66734a24349acad2239861e379c