Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Richard A, Baines"'
Autor:
Katerina Karkali, Samuel W. Vernon, Richard A. Baines, George Panayotou, Enrique Martín-Blanco
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Central nervous system organogenesis is a complex process that obeys precise architectural rules. The impact that nervous system architecture may have on its functionality remains, however, relatively unexplored. To clarify this problem, we
Externí odkaz:
https://doaj.org/article/b866f92b75464a13a267f89280a79503
Autor:
Iain Hunter, Bramwell Coulson, Tom Pettini, Jacob J Davies, Jill Parkin, Matthias Landgraf, Richard A Baines
Publikováno v:
eLife, Vol 12 (2024)
Developing neural circuits are influenced by activity and are especially sensitive to changes in activity during critical periods (CPs) of development. Changes occurring during a CP often become ‘locked in’ so that they affect the mature network.
Externí odkaz:
https://doaj.org/article/ed5b3281f43f47c8b47904573a6b08e9
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Pathogenic, generally loss-of-function, variants in CACNA1F, encoding the Cav1.4α1 calcium channel, underlie congenital stationary night blindness type 2 (CSNB2), a rare inherited retinal disorder associated with visual disability. To establish the
Externí odkaz:
https://doaj.org/article/ea95a08335d741358eff488fdede1979
Autor:
Bramwell Coulson, Iain Hunter, Sarah Doran, Jill Parkin, Matthias Landgraf, Richard A. Baines
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Critical periods are phases of heightened plasticity that occur during the development of neural networks. Beginning with pioneering work of Hubel and Wiesel, which identified a critical period for the formation of ocular dominance in mammalian visua
Externí odkaz:
https://doaj.org/article/e7c2e36328d444fb925fba15b9d5a1b0
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The emergence of coordinated network function during nervous system development is often associated with critical periods. These phases are sensitive to activity perturbations during, but not outside, of the critical period, that can lead to
Externí odkaz:
https://doaj.org/article/29e075c889904dd6829db8ff6d285137
Autor:
Fred Mulroe, Wei-Hsiang Lin, Connie Mackenzie-Gray Scott, Najat Aourz, Yuen Ngan Fan, Graham Coutts, R. Ryley Parrish, Ilse Smolders, Andrew Trevelyan, Robert C. Wykes, Stuart Allan, Sally Freeman, Richard A. Baines
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 10 (2022)
Externí odkaz:
https://doaj.org/article/3c30c2a06d484e9abf1e1f9a183c7038
Publikováno v:
Quantum Reports, Vol 3, Iss 1, Pp 127-136 (2021)
The flavoprotein CRYPTOCHROME (CRY) is now generally believed to be a magnetosensor, providing geomagnetic information via a quantum effect on a light-initiated radical pair reaction. Whilst there is considerable physical and behavioural data to supp
Externí odkaz:
https://doaj.org/article/8ccfe3e353614548b6023d88a5dda124
Autor:
Ryan J. H. West, Joanne L. Sharpe, André Voelzmann, Anna L. Munro, Ines Hahn, Richard A. Baines, Stuart Pickering-Brown
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract A large intronic hexanucleotide repeat expansion (GGGGCC) within the C9orf72 (C9orf72-SMCR8 Complex Subunit) locus is the most prevalent genetic cause of both Frontotemporal Dementia (FTD) and Motor Neuron Disease (MND). In patients this exp
Externí odkaz:
https://doaj.org/article/4e9a52c5a5ea4a479ca7cd7829ad0e49
Autor:
Suzanne H. Hodge, Amy Watts, Richard Marley, Richard A. Baines, Ernst Hafen, Lindsay K. MacDougall
Publikováno v:
Biology Open, Vol 10, Iss 8 (2021)
Primary cilia are compartmentalised from the rest of the cell by a ciliary gate comprising transition fibres and a transition zone. The ciliary gate allows the selective import and export of molecules such as transmembrane receptors and transport pro
Externí odkaz:
https://doaj.org/article/9e5f0341c9ef4e479eefd7e98fef7c76
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
It is difficult to answer important questions in neuroscience, such as: “how do neural circuits generate behaviour?,” because research is limited by the complexity and inaccessibility of the mammalian nervous system. Invertebrate model organisms
Externí odkaz:
https://doaj.org/article/61e661d1ca294620840f0efa5d3a4262