Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Richard van Breemen"'
Publikováno v:
Toxicology Communications, Vol 6, Iss 1, Pp 28-29 (2022)
Externí odkaz:
https://doaj.org/article/37ccbd92802e46b4876c2ef4553fd36b
Autor:
Rima Rebiai, Emily Rue, Steve Zaldua, Duc Nguyen, Giuseppe Scesa, Martin Jastrzebski, Robert Foster, Bin Wang, Xuntian Jiang, Leon Tai, Scott T. Brady, Richard van Breemen, Maria I. Givogri, Mark S. Sands, Ernesto R. Bongarzone
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Krabbe Disease (KD) is a lysosomal storage disorder characterized by the genetic deficiency of the lysosomal enzyme β-galactosyl-ceramidase (GALC). Deficit or a reduction in the activity of the GALC enzyme has been correlated with the progressive ac
Externí odkaz:
https://doaj.org/article/ebdde43cc35d4f9e87b3d663556551e0
Autor:
Cory R. Reiter, Rima Rebiai, Angelika Kwak, Jeff Marshall, Dylan Wozniak, Giusepe Scesa, Duc Nguyen, Emily Rue, Koralege C. Pathmasiri, Robert Pijewski, Richard van Breemen, Stephanie Cologna, Stephen J. Crocker, M Irene Givogri, Ernesto R Bongarzone
Publikováno v:
ASN Neuro, Vol 14 (2022)
Psychosine exerts most of its toxic effects by altering membrane dynamics with increased shedding of extracellular vesicles (EVs). In this study, we discovered that a fraction of psychosine produced in the brain of the Twitcher mouse, a model for Kra
Externí odkaz:
https://doaj.org/article/4a45a69642534fae9ba02c13cb43e826
Autor:
Erik Wright, John W. Hafner, Gregory Podolej, Douglas L. Feinstein, Richard van Breemen, Israel Rubinstein, Steven Aks, Michael Wahl
Publikováno v:
Western Journal of Emergency Medicine, Vol 22, Iss 4 (2021)
Introduction: Synthetic cannabinoids are a rapidly expanding subset of designer drugs widely available in the United States since 2008. In Illinois during the spring of 2018, over 160 documented cases of bleeding and prolonged coagulopathy occurred s
Externí odkaz:
https://doaj.org/article/38695cacf4fe4b2c8e05a84b92070a73
Autor:
Israel Rubinstein, Richard van Breemen, Daniel G. Nosal, Guy Weinberg, Ronald C. Hershow, Douglas L. Feinstein
Publikováno v:
Drugs in R&D, Vol 19, Iss 1, Pp 67-71 (2019)
Abstract A recent multi-state outbreak of life-threatening bleeding following inhalation of synthetic cannabinoids has been attributed to contamination with the long-acting anticoagulant rodenticide (LAAR) brodifacoum, a second-generation, highly pot
Externí odkaz:
https://doaj.org/article/e20f4ca682714b6a854ca8e11188b24f
Autor:
Hazem Abdelkarim, Michael S. Marshall, Giuseppe Scesa, Rachael A. Smith, Emily Rue, Jeffrey Marshall, Vince Elackattu, Monika Stoskute, Yazan Issa, Marta Santos, Duc Nguyen, Zane Hauck, Richard van Breemen, Maria S. Celej, Vadim Gaponenko, Ernesto R. Bongarzone
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-19 (2018)
Abstract Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson’s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation of glycosph
Externí odkaz:
https://doaj.org/article/4adc82051b0144b0a3f11de190f2a080
Autor:
Ludovic D'Auria, Cory Reiter, Emma Ward, Ana Lis Moyano, Michael S Marshall, Duc Nguyen, Giuseppe Scesa, Zane Hauck, Richard van Breemen, Maria I Givogri, Ernesto R Bongarzone
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178103 (2017)
In prior studies, our laboratory showed that psychosine accumulates and disrupts lipid rafts in brain membranes of Krabbe's disease. A model of lipid raft disruption helped explaining psychosine's effects on several signaling pathways important for o
Externí odkaz:
https://doaj.org/article/ca8105b7c3f14e91ac45052c586ae20a
Autor:
Richard van Breemen, Alan Wong
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S76
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3723b9c664e4e91ac58eb2d82f3be9dd
https://doi.org/10.1016/j.dmpk.2020.04.176
https://doi.org/10.1016/j.dmpk.2020.04.176
Autor:
Richard, van Breemen, Joseph M, Betz, Lisa, Evans, April, Hall, Martha, Jennens, Rachel, Kreider, Adam, Kuszak, Elizabeth, Mudge, Punam, Patel, Melissa Meaney, Phillips, Catherine A, Rimmer, Brian T, Schaneberg, Anand, Sheshadri, Aniko M, Solyom, Darryl M, Sullivan, John, Szpylka, Denise Lowe, Walters, Tyler, White, Jinchuan, Yang, Kurt, Young, Garrett, Zielinski, Scott G, Coates
Publikováno v:
Journal of AOAC International. 100(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c30e3101d4f83e99b947e091e5dcf503
https://pubmed.ncbi.nlm.nih.gov/28825562
https://pubmed.ncbi.nlm.nih.gov/28825562
Autor:
Douglas L, Feinstein, Belinda S, Akpa, Manuela A, Ayee, Anne I, Boullerne, David, Braun, Sergey V, Brodsky, David, Gidalevitz, Zane, Hauck, Sergey, Kalinin, Kathy, Kowal, Ivan, Kuzmenko, Kinga, Lis, Natalia, Marangoni, Michael W, Martynowycz, Israel, Rubinstein, Richard, van Breemen, Kyle, Ware, Guy, Weinberg
Publikováno v:
Annals of the New York Academy of Sciences. 1374(1)
Superwarfarins were developed following the emergence of warfarin resistance in rodents. Superwarfarins have much longer half-lives and stronger affinity to vitamin K epoxide reductase versus warfarin, and therefore can cause death in warfarin-resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3127a8492457c2186ce8e6cd265cf7f
https://pubmed.ncbi.nlm.nih.gov/27244102
https://pubmed.ncbi.nlm.nih.gov/27244102