Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Richard Lathe"'
Autor:
Heather E. Whitson, William A. Banks, Monica M. Diaz, Bess Frost, Manolis Kellis, Richard Lathe, Kenneth E. Schmader, Serena S. Spudich, Rudolph Tanzi, Gwenn Garden
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 36, Iss , Pp 100743- (2024)
Alzheimer's disease (AD) involves a complex pathological process that evolves over years, and its etiology is understood as a classic example of gene-environment interaction. The notion that exposure to microbial organisms may play some role in AD pa
Externí odkaz:
https://doaj.org/article/a8b84dfe6a364ca4aa96dc21a9e45b62
Publikováno v:
BMC Microbiology, Vol 22, Iss 1, Pp 1-27 (2022)
Abstract Background Microbiome analysis generally requires PCR-based or metagenomic shotgun sequencing, sophisticated programs, and large volumes of data. Alternative approaches based on widely available RNA-seq data are constrained because of sequen
Externí odkaz:
https://doaj.org/article/a1014835a6e049eea5b9398a1ddef8ea
Autor:
Richard Lathe
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2023)
Externí odkaz:
https://doaj.org/article/9c37671fe5014b9181cf880a5d0fa294
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced
Externí odkaz:
https://doaj.org/article/1aa49262cf1d481782e39b03e2c220a8
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227575 (2020)
The primeval function of the mammalian hippocampus (HPC) remains uncertain. Implicated in learning and memory, spatial navigation, and neuropsychological disorders, evolutionary theory suggests that the HPC evolved from a primeval chemosensory epithe
Externí odkaz:
https://doaj.org/article/1e02a11a71984f2fb610ec76d70a7466
Autor:
Richard Lathe
In this controversial new book, Lathe contends that the recent rise in cases of ASDs is a result of increased exposure to environmental toxicity combined with genetic predisposition. He proposes that autism is a disorder of the limbic brain, which is
Autor:
Richard Lathe, David St. Clair
Publikováno v:
Lathe, R & Clair, D S 2023, ' Programmed ageing: decline of stem cell renewal, immunosenescence, and Alzheimer’s disease ', Biological reviews of the cambridge philosophical society . https://doi.org/10.1111/brv.12959
The characteristic maximum lifespan varies enormously across animal species from a few hours to hundreds of years. This argues that maximum lifespan, and the ageing process that itself dictates lifespan, are to a large extent genetically determined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b92755dbef95a4f045291bd6a4f702
https://doi.org/10.1111/brv.12959
https://doi.org/10.1111/brv.12959
Publikováno v:
Houston, D R, Hanna, J, Lathe, J C, Hillier, S & Lathe, R 2022, ' Evidence that nuclear receptors are related to terpene synthases ', Journal of molecular endocrinology, pp. 153-166 . https://doi.org/10.1530/JME-21-0156
Ligand-activated nuclear receptors (NRs) orchestrate development, growth, and reproduction across all animal lifeforms – the Metazoa – but how NRs evolved remains mysterious. Given the NR ligands including steroids and retinoids are predominantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11156b10227fb3239ed12b7b18199e9f
https://doi.org/10.1530/jme-21-0156
https://doi.org/10.1530/jme-21-0156
Autor:
Richard Lathe, Nikki M. Schultek, Brian J. Balin, Garth D. Ehrlich, Lavinia Alberi Auber, George Perry, Edward B. Breitschwerdt, David B. Corry, Richard L. Doty, Robert A. Rissman, Peter L. Nara, Ruth Itzhaki, William A. Eimer, Rudolph E. Tanzi, Intracell Research Group Consortium Collaborators
Microbial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e885362d69dc150920963f84fabf3a
https://doi.org/10.21203/rs.3.rs-2617541/v1
https://doi.org/10.21203/rs.3.rs-2617541/v1
Microbes in human brain and their potential contribution to neurodegenerative conditions such as Alzheimer’s disease (AD) have long been debated. We recently developed a new method (the electronic tree of life, eToL) based on small subunit ribosoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0f8b309474fec70beb113521598079
https://doi.org/10.1101/2023.02.06.527297
https://doi.org/10.1101/2023.02.06.527297