Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Richard, Woessner"'
Autor:
Felix Scheuplein, Florian Renner, John E. Campbell, Robert Campbell, Chris De Savi, Jan Eckmann, Holger Fischer, Jie Ge, Luke Green, Peter Jakob, Joseph L. Kim, Caitlin Kinkema, Katie McGinn, Ricardo Medina, Annemarie Müller, Nisha Perez, Emanuele Perola, Yoav Timsit, Tary Traore, Ulrike Hopfer, Stefka Tyanova, Manuel Tzouros, Ruduan Wang, Richard Woessner, Marion Dorsch, James R. Bischoff
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe serine/threonine kinase 17B (STK17B) is involved in setting the threshold for T cell activation and its absence sensitizes T cells to suboptimal stimuli. Consequently, STK17B represents an attractive potential target for cancer immuno
Externí odkaz:
https://doaj.org/article/301b248df8e548fc8ca6b2a6315e5115
Autor:
Stefanie S. Schalm, Erin O’Hearn, Kevin Wilson, Timothy P. LaBranche, Grace Silva, Zhuo Zhang, Lucian DiPietro, Neil Bifulco, Richard Woessner, Nicolas Stransky, Darshan Sappal, Robert Campbell, Riadh Lobbardi, Michael Palmer, Joseph Kim, Chaoyang Ye, Marion Dorsch, Christoph Lengauer, Timothy Guzi, Vivek Kadambi, Andrew Garner, Klaus P. Hoeflich
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 3, Pp 307-321 (2023)
Background and Aims: Fibrolamellar carcinoma (FLC) is a rare, difficult-to-treat liver cancer primarily affecting pediatric and adolescent patients, and for which precision medicine approaches have historically not been possible. The DNAJB1-PRKACA ge
Externí odkaz:
https://doaj.org/article/2154c1b576ce47429fad42ed3d908a8f
Autor:
Veronika Voronova, Kirill Peskov, Yuri Kosinsky, Gabriel Helmlinger, Lulu Chu, Alexandra Borodovsky, Richard Woessner, Kris Sachsenmeier, Wenlin Shao, Rakesh Kumar, Gayle Pouliot, Melinda Merchant, Holly Kimko, Ganesh Mugundu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundAdenosine receptor type 2 (A2AR) inhibitor, AZD4635, has been shown to reduce immunosuppressive adenosine effects within the tumor microenvironment (TME) and to enhance the efficacy of checkpoint inhibitors across various syngeneic models.
Externí odkaz:
https://doaj.org/article/1a1c06171901426c87250762be86e987
Autor:
Carman K. M. Ip, Patrick K. S. Ng, Kang Jin Jeong, S. H. Shao, Zhenlin Ju, P. G. Leonard, Xu Hua, Christopher P. Vellano, Richard Woessner, Nidhi Sahni, Kenneth L. Scott, Gordon B. Mills
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Activation of PDGFRA by genomic aberrations contributes to tumor progression in several tumor types. Here, the authors perform functional characterization of 16 novel PDGFRA mutations identified from different tumor types and demonstrate that a neomo
Externí odkaz:
https://doaj.org/article/5afbb5f4318a4d348864297344880429
Autor:
Matthew J. Reilley, Patricia McCoon, Carl Cook, Paul Lyne, Razelle Kurzrock, Youngsoo Kim, Richard Woessner, Anas Younes, John Nemunaitis, Nathan Fowler, Michael Curran, Qinying Liu, Tianyuan Zhou, Joanna Schmidt, Minji Jo, Samantha J. Lee, Mason Yamashita, Steven G. Hughes, Luis Fayad, Sarina Piha-Paul, Murali V. P. Nadella, Xiaokun Xiao, Jeff Hsu, Alexey Revenko, Brett P. Monia, A. Robert MacLeod, David S. Hong
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-10 (2018)
Abstract Background The Janus kinase (JAK) and signal transduction and activation of transcription (STAT) signaling pathway is an attractive target in multiple cancers. Activation of the JAK-STAT pathway is important in both tumorigenesis and activat
Externí odkaz:
https://doaj.org/article/f4f7c89c60164d3da2e398789b9d791f
These are the original Supplementary Figures S2-S4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd038e47da2bee0f8fa3f476ae66cefc
https://doi.org/10.1158/1078-0432.22464344
https://doi.org/10.1158/1078-0432.22464344
Autor:
Patricia McCoon, J. Carl Barrett, Corinne Reimer, Simon Barry, Stephen Fawell, Deanna A. Mele, Nanhua Deng, Adina Hughes, Mingchao Xie, Deanna Russell, Susan Cantin, Minwei Ye, Matthew Griffin, Chris Womack, Mike Collins, Shaun Grosskurth, Srimathi Srinivasan, Lukasz Magiera, Gayathri Bommakanti, Larissa Carnevalli, Richard Woessner, Maneesh Singh, Theresa A. Proia
Syngeneic mouse tumor efficacy, STAT3, and gene expression changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939ae37c2c3f28af798b763c95a94fb7
https://doi.org/10.1158/1078-0432.22477031.v1
https://doi.org/10.1158/1078-0432.22477031.v1
Purpose: Neuroblastoma is a pediatric tumor of peripheral sympathoadrenal neuroblasts. The long-term event-free survival of children with high-risk neuroblastoma is still poor despite the improvements with current multimodality treatment protocols. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3897768451b879fc13531fbffa9c7e0
https://doi.org/10.1158/1078-0432.c.6525680
https://doi.org/10.1158/1078-0432.c.6525680
Autor:
Patricia McCoon, J. Carl Barrett, Corinne Reimer, Simon Barry, Stephen Fawell, Deanna A. Mele, Nanhua Deng, Adina Hughes, Mingchao Xie, Deanna Russell, Susan Cantin, Minwei Ye, Matthew Griffin, Chris Womack, Mike Collins, Shaun Grosskurth, Srimathi Srinivasan, Lukasz Magiera, Gayathri Bommakanti, Larissa Carnevalli, Richard Woessner, Maneesh Singh, Theresa A. Proia
Patient STAT reductions and reproducibility of replicates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fb304ec4643c56200b7275c15c8436
https://doi.org/10.1158/1078-0432.22477028.v1
https://doi.org/10.1158/1078-0432.22477028.v1
Autor:
Patricia McCoon, J. Carl Barrett, Corinne Reimer, Simon Barry, Stephen Fawell, Deanna A. Mele, Nanhua Deng, Adina Hughes, Mingchao Xie, Deanna Russell, Susan Cantin, Minwei Ye, Matthew Griffin, Chris Womack, Mike Collins, Shaun Grosskurth, Srimathi Srinivasan, Lukasz Magiera, Gayathri Bommakanti, Larissa Carnevalli, Richard Woessner, Maneesh Singh, Theresa A. Proia
Patient sample details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205d7af9f5b65bc010cb117b043e74d8
https://doi.org/10.1158/1078-0432.22477016
https://doi.org/10.1158/1078-0432.22477016