Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Richard, Tjhen"'
Autor:
Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, Yukiko Yamamoto, Toshiya Tamura, Daisuke Nakata, Ryo Dairiki, Yoichi Kawakita, Ryo Mizojiri, Yoshiteru Ito, Moriteru Asano, Hironobu Maezaki, Yusuke Nakayama, Misato Kaishima, Kozo Hayashi, Mika Teratani, Shuichi Miyakawa, Misa Iwatani, Maki Miyamoto, Michael G Klein, Wes Lane, Gyorgy Snell, Richard Tjhen, Xingyue He, Sai Pulukuri, Toshiyuki Nomura
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 6, Pp n/a-n/a (2018)
Abstract The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy, especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that T‐025 functions as an orally available and potent
Externí odkaz:
https://doaj.org/article/5f979a579b0246ad90c5cfcded6e406d
Autor:
Richard Tjhen, Noriko Uchiyama, Michiko Tawada, Yohei Kosugi, Satoshi Endo, Huikai Sun, Kei Masuda, Makoto Fushimi, Tatsuki Koike, Weston Lane
Publikováno v:
Journal of Medicinal Chemistry. 64:1103-1115
O-GlcNAcase (OGA) has received increasing attention as an attractive therapeutic target for tau-mediated neurodegenerative disorders; however, its role in these pathologies remains unclear. Therefore, potent chemical tools with favorable pharmacokine
Autor:
Osamu Kurasawa, Yasutomi Asano, Ke Li, Hiroshi Banno, Jun Fujimoto, Georgia Kefala, Gyorgy Snell, Irena Levin, Takuto Kojima, Ryo Mizojiri, Bi-Ching Sang, Richard Tjhen, Michael G. Klein, Scott Weston Lane, Isaac Hoffman, Tsuyoshi Ishii, Douglas R. Cary, Xin Liu, Akito Hata, Tadahiro Nambu, Yasuyuki Debori, Tomoya Sameshima, Terufumi Takagi, Steve C. Ding, Akito Nakamura, Maki Miyamoto
Publikováno v:
ACS Med Chem Lett
[Image: see text] General control nonderepressible 2 (GCN2) is a master regulator kinase of amino acid homeostasis and important for cancer survival in the tumor microenvironment under amino acid depletion. We initiated studies aiming at the discover
Autor:
Michiko, Tawada, Makoto, Fushimi, Kei, Masuda, Huikai, Sun, Noriko, Uchiyama, Yohei, Kosugi, Weston, Lane, Richard, Tjhen, Satoshi, Endo, Tatsuki, Koike
Publikováno v:
Journal of medicinal chemistry. 64(2)
Autor:
Misato Kaishima, Ryo Mizojiri, Michael G. Klein, Xingyue He, Yoichi Kawakita, Toshiya Tamura, Hironobu Maezaki, Moriteru Asano, Sai M Pulukuri, Ryo Dairiki, Shuichi Miyakawa, Yusuke Nakayama, Kozo Hayashi, Richard Tjhen, Kenichi Iwai, Kazuho Nishimura, Misa Iwatani, Maki Miyamoto, Gyorgy Snell, Masahiro Yaguchi, Yukiko Yamamoto, Daisuke Nakata, Toshiyuki Nomura, Wes Lane, Yoshiteru Ito, Mika Teratani
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 6, Pp n/a-n/a (2018)
The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy, especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that T‐025 functions as an orally available and potent inhibito
Autor:
Michael G. Klein, Masanori Miwa, Daisuke Morishita, Kazuko Yonemori, Masahiro Ito, Toshio Tanaka, Atsushi Nakanishi, Richard Tjhen, Ling Qin, Hironobu Maezaki, Tomohiro Kawamoto, Takeshi Yamamoto, Satoshi Endo, Misa Iwatani-Yoshihara
Publikováno v:
Journal of medicinal chemistry. 60(13)
Brr2 is an RNA helicase belonging to the Ski2-like subfamily and an essential component of spliceosome. Brr2 catalyzes an ATP-dependent unwinding of the U4/U6 RNA duplex, which is a critical step for spliceosomal activation. An HTS campaign using an
Autor:
Andrew John Jennings, Yelena Istratiy, Mark S. Hixon, Derek C. Cole, Phillip A. Schwartz, Richard Tjhen, Marion Lanier, Michael G. Klein
Publikováno v:
Journal of Medicinal Chemistry
Serine hydrolases are susceptible to potent reversible inhibition by boronic acids. Large collections of chemically diverse boronic acid fragments are commercially available because of their utility in coupling chemistry. We repurposed the approximat
Publikováno v:
Journal of Biological Chemistry. 283:28757-28766
Poly(C)-binding proteins (PCBPs) are important regulatory proteins that contain three KH (hnRNP K homology) domains. Binding poly(C) D/RNA sequences via KH domains is essential for multiple PCBP functions. To reveal the basis for PCBP-D/RNA interacti
Publikováno v:
Proceedings of the National Academy of Sciences. 105:2391-2396
Dicer, an RNase III enzyme, initiates RNA interference by processing precursor dsRNAs into mature microRNAs and small-interfering RNAs. It is also involved in loading and activation of the RNA-induced silencing complex. Here, we report the crystal st
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 35, iss 8
Nucleic acids research, vol 35, iss 8
KH (hnRNP K homology) domains, consisting of approximately 70 amino acid residues, are present in a variety of nucleic-acid-binding proteins. Among these are poly(C)-binding proteins (PCBPs), which are important regulators of mRNA stability and postt