Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Richard, Milner"'
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Interactions between extracellular matrix (ECM) proteins and β1 integrins play an essential role maintaining vascular integrity in the brain, particularly under vascular remodeling conditions. As blood vessels in the spinal cord are reporte
Externí odkaz:
https://doaj.org/article/2087fb5ca2174f71b2bd6bae24a15573
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-16 (2023)
Abstract Background Maintaining a tight blood–brain barrier (BBB) is an important prerequisite for the preservation of neurological health, though current evidence suggests it declines with age. While extracellular matrix-integrin interactions play
Externí odkaz:
https://doaj.org/article/5d0b48c365d6408cb41c6c0149a70f6b
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 12, Pp 2557-2563 (2023)
The blood-brain barrier is a unique property of central nervous system blood vessels that protects sensitive central nervous system cells from potentially harmful blood components. The mechanistic basis of this barrier is found at multiple levels, in
Externí odkaz:
https://doaj.org/article/5760e6faad5447fe847950586b54f485
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-12 (2022)
Abstract Blood vessels in the central nervous system (CNS) are unique in having high electrical resistance and low permeability, which creates a selective barrier protecting sensitive neural cells within the CNS from potentially harmful components in
Externí odkaz:
https://doaj.org/article/0b6869dcd1ec4830857bbfa2e3f03ffb
Autor:
Sebok K. Halder, Richard Milner
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Chronic mild hypoxia (CMH, 8% O2) stimulates robust vascular remodelling in the brain, but it also triggers transient vascular disruption. This raises the fundamental question: is the vascular leak an unwanted side-effect of angio
Externí odkaz:
https://doaj.org/article/cd64671c5826419795e33483102dc817
Autor:
James J. Yu, Amy L. Non, Erica C. Heinrich, Wanjun Gu, Joe Alcock, Esteban A. Moya, Elijah S. Lawrence, Michael S. Tift, Katie A. O'Brien, Jay F. Storz, Anthony V. Signore, Jane I. Khudyakov, William K. Milsom, Sean M. Wilson, Cynthia M. Beall, Francisco C. Villafuerte, Tsering Stobdan, Colleen G. Julian, Lorna G. Moore, Mark M. Fuster, Jennifer A. Stokes, Richard Milner, John B. West, Jiao Zhang, John Y. Shyy, Ainash Childebayeva, José Pablo Vázquez-Medina, Luu V. Pham, Omar A. Mesarwi, James E. Hall, Zachary A. Cheviron, Jeremy Sieker, Arlin B. Blood, Jason X. Yuan, Graham R. Scott, Brinda K. Rana, Paul J. Ponganis, Atul Malhotra, Frank L. Powell, Tatum S. Simonson
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypo
Externí odkaz:
https://doaj.org/article/ad6281793d794d10a1e325e2249296a9
Autor:
Sebok K. Halder, Richard Milner
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11235 (2023)
In response to chronic mild hypoxia (CMH, 8% O2), spinal cord blood vessels launch a robust angiogenic response that is associated with transient disruption of the blood–spinal cord barrier (BSCB) which, in turn, triggers a microglial vasculo-prote
Externí odkaz:
https://doaj.org/article/2e548c7ef42c41e9962aac536d91f501
Autor:
Liana V. Basova, Savannah Eve Lukkes, Richard Milner, Ronald J. Ellis, Mariana Cherner, Jennifer Iudicello, Maria Cecilia Garibaldi Marcondes
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 20, Iss , Pp 100414- (2022)
In spite of suppressive antiretroviral therapies (ART), Human Immunodeficiency Virus (HIV)-infected subjects still experience the consequences of viral persistence and chronic inflammation. In the brain, where most HIV-1 targets are of innate immune
Externí odkaz:
https://doaj.org/article/595224fd3203471eb90eb367104aa140
Autor:
Sebok K. Halder, Richard Milner
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract We recently demonstrated that when mice are exposed to chronic mild hypoxia (CMH, 8% O2), blood vessels in the spinal cord show transient vascular leak that is associated with clustering and activation of microglia around disrupted vessels.
Externí odkaz:
https://doaj.org/article/2f24194a8d4649aebcc9c8f1f3c939df
Autor:
Bryant O. Best, H. Richard Milner IV
Publikováno v:
Race Ethnicity and Education. 26:516-532