Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Richard, Lupat"'
Moanna: Multi-Omics Autoencoder-Based Neural Network Algorithm for Predicting Breast Cancer Subtypes
Publikováno v:
IEEE Access, Vol 11, Pp 10912-10924 (2023)
Cancer subtyping delivers valuable insights into the study of cancer heterogeneity and fulfills an essential step toward personalized medicine. For example, studies in breast cancer have shown that cancer subtypes based on molecular differences are a
Externí odkaz:
https://doaj.org/article/1a35ec6ee62d4fd793cadaba0110e28f
Autor:
Glen R. Guerra, Joseph C. Kong, Rosemary M. Millen, Matthew Read, David S. Liu, Sara Roth, Shienny Sampurno, Joseph Sia, Maria-Pia Bernardi, Timothy J. Chittleborough, Corina C. Behrenbruch, Jiasian Teh, Huiling Xu, Nicole M. Haynes, Jiaan Yu, Richard Lupat, David Hawkes, Natasha Di Costanzo, Richard W. Tothill, Catherine Mitchell, Samuel Y. Ngan, Alexander G. Heriot, Robert G. Ramsay, Wayne A. Phillips
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-15 (2021)
Abstract Anal cancer is a rare disease that has doubled in incidence over the last four decades. Current treatment and survival of patients with this disease has not changed substantially over this period of time, due, in part, to a paucity of precli
Externí odkaz:
https://doaj.org/article/f18d31fc26fb4a7987f5b99e3a2cb440
Autor:
Sally M. Hunter, Genevieve V. Dall, Maria A. Doyle, Richard Lupat, Jason Li, Prue Allan, Simone M. Rowley, David Bowtell, On behalf of AOCS, Ian G. Campbell, Kylie L. Gorringe
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-8 (2020)
Abstract Objective Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal cells (pure fibroma) or a mixture of fibroblast and epithelial components (adenofibroma). We have previously show
Externí odkaz:
https://doaj.org/article/b04951423f094474882d7f56bebcc2fa
Autor:
Dane Cheasley, Matthew J. Wakefield, Georgina L. Ryland, Prue E. Allan, Kathryn Alsop, Kaushalya C. Amarasinghe, Sumitra Ananda, Michael S. Anglesio, George Au-Yeung, Maret Böhm, David D. L. Bowtell, Alison Brand, Georgia Chenevix-Trench, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Renee Demeo, Rhiannon Dudley, Nicole Fairweather, Clare G. Fedele, Sian Fereday, Stephen B. Fox, C Blake Gilks, Charlie Gourley, Neville F. Hacker, Alison M. Hadley, Joy Hendley, Gwo-Yaw Ho, Siobhan Hughes, David G. Hunstman, Sally M. Hunter, Tom W. Jobling, Kimberly R. Kalli, Scott H. Kaufmann, Catherine J. Kennedy, Martin Köbel, Cecile Le Page, Jason Li, Richard Lupat, Orla M. McNally, Jessica N. McAlpine, Anne-Marie Mes-Masson, Linda Mileshkin, Diane M. Provencher, Jan Pyman, Kurosh Rahimi, Simone M. Rowley, Carolina Salazar, Goli Samimi, Hugo Saunders, Timothy Semple, Ragwha Sharma, Alice J. Sharpe, Andrew N. Stephens, Niko Thio, Michelle C. Torres, Nadia Traficante, Zhongyue Xing, Magnus Zethoven, Yoland C. Antill, Clare L. Scott, Ian G. Campbell, Kylie L. Gorringe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Whether mucinous ovarian carcinoma (MOC) arises from cells at the ovary or from metastases from other primary sites is an unanswered question. Here, Cheasley et al perform a genetic analysis of the disease, showing that MOC arises at the ovary.
Externí odkaz:
https://doaj.org/article/9047c1d475514bf5becaaddcde7c44d4
Autor:
Na Li, Simone M. Rowley, Ella R. Thompson, Simone McInerny, Lisa Devereux, Kaushalya C. Amarasinghe, Magnus Zethoven, Richard Lupat, David Goode, Jason Li, Alison H. Trainer, Kylie L. Gorringe, Paul A. James, Ian G. Campbell
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-11 (2018)
Abstract Background Genome-wide association studies (GWASs) have identified numerous single-nucleotide polymorphisms (SNPs) associated with small increases in breast cancer risk. Studies to date suggest that some SNPs alter the expression of the asso
Externí odkaz:
https://doaj.org/article/87e91e02038b476ca773dac090bf25d6
Autor:
Marcus Lefebure, Richard W. Tothill, Elizabeth Kruse, Edwin D. Hawkins, Jake Shortt, Geoffrey M. Matthews, Gareth P. Gregory, Benjamin P. Martin, Madison J. Kelly, Izabela Todorovski, Maria A. Doyle, Richard Lupat, Jason Li, Jan Schroeder, Meaghan Wall, Stuart Craig, Gretchen Poortinga, Don Cameron, Megan Bywater, Lev Kats, Micah D. Gearhart, Vivian J. Bardwell, Ross A. Dickins, Ross D. Hannan, Anthony T. Papenfuss, Ricky W. Johnstone
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The Eμ-Myc lymphoma mouse model has been invaluable in the study of this disease. Here, the authors use multiple sequencing strategies to analyse the tumours in these mice and find recurrent inactivating mutations in Bcor, suggesting that this gene
Externí odkaz:
https://doaj.org/article/0c3aa501a43e4f4f934206118b33d4f2
Autor:
Rachel, Delahunty, Linh, Nguyen, Stuart, Craig, Belinda, Creighton, Dinuka, Ariyaratne, Dale W, Garsed, Elizabeth, Christie, Sian, Fereday, Lesley, Andrews, Alexandra, Lewis, Sharne, Limb, Ahwan, Pandey, Joy, Hendley, Nadia, Traficante, Natalia, Carvajal, Amanda B, Spurdle, Bryony, Thompson, Michael T, Parsons, Victoria, Beshay, Mila, Volcheck, Timothy, Semple, Richard, Lupat, Kenneth, Doig, Jiaan, Yu, Xiao Qing, Chen, Anna, Marsh, Christopher, Love, Sanela, Bilic, Maria, Beilin, Cassandra B, Nichols, Christina, Greer, Yeh Chen, Lee, Susan, Gerty, Lynette, Gill, Emma, Newton, Julie, Howard, Rachel, Williams, Christie, Norris, Andrew N, Stephens, Erin, Tutty, Courtney, Smyth, Shona, O'Connell, Thomas, Jobling, Colin J R, Stewart, Adeline, Tan, Stephen B, Fox, Nicholas, Pachter, Jason, Li, Jason, Ellul, Gisela, Mir Arnau, Mary-Anne, Young, Louisa, Gordon, Laura, Forrest, Marion, Harris, Karen, Livingstone, Jane, Hill, Georgia, Chenevix-Trench, Paul A, Cohen, Penelope M, Webb, Michael, Friedlander, Paul, James, David, Bowtell, Kathryn, Alsop
Publikováno v:
Journal of Clinical Oncology. 40:2036-2047
PURPOSE Tubo-ovarian cancer (TOC) is a sentinel cancer for BRCA1 and BRCA2 pathogenic variants (PVs). Identification of a PV in the first member of a family at increased genetic risk (the proband) provides opportunities for cancer prevention in other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d66ca017250ec5b60c0dd8770470563
https://doi.org/10.1200/jco.21.02108
https://doi.org/10.1200/jco.21.02108
Autor:
Richard W. Tothill, Rodney J. Hicks, Anthony J. Gill, Richard A. Scolyer, Anthony T. Papenfuss, Grant A. McArthur, Stephen B. Fox, Ricky W. Johnstone, David D.L. Bowtell, Shahneen Sandhu, Mark Shackleton, Meredith Johnston, Carleen Cullinane, John F. Thompson, Graham J. Mann, George Hruby, J. Helen Leonard, Andrew Fellowes, Gisela Mir Arnau, Timothy Semple, Richard Lupat, Jason Li, Ricardo De Paoli-Iseppi, Andrew J. Colebatch, James S. Wilmott, Jason Madore, Jan Schröder, Ismael A. Vergara, Kelly Waldeck, Stephen Q. Wong
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2bd6c2904906725f53a300b43b93317
https://doi.org/10.1158/0008-5472.22408167.v1
https://doi.org/10.1158/0008-5472.22408167.v1
Autor:
Richard W. Tothill, Rodney J. Hicks, Anthony J. Gill, Richard A. Scolyer, Anthony T. Papenfuss, Grant A. McArthur, Stephen B. Fox, Ricky W. Johnstone, David D.L. Bowtell, Shahneen Sandhu, Mark Shackleton, Meredith Johnston, Carleen Cullinane, John F. Thompson, Graham J. Mann, George Hruby, J. Helen Leonard, Andrew Fellowes, Gisela Mir Arnau, Timothy Semple, Richard Lupat, Jason Li, Ricardo De Paoli-Iseppi, Andrew J. Colebatch, James S. Wilmott, Jason Madore, Jan Schröder, Ismael A. Vergara, Kelly Waldeck, Stephen Q. Wong
MCC Patient characteristics (S1); Extension cohort of MCCs (S2); List of genes represented on the targeted sequencing panel (S3); Performance metrics for targeted sequencing and low coverage WGS (S4); Validation of mutations by orthogonal genotyping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82aff7dd79c7ef20c4413915076b1e5e
https://doi.org/10.1158/0008-5472.22408164.v1
https://doi.org/10.1158/0008-5472.22408164.v1
Autor:
Richard W. Tothill, Rodney J. Hicks, Anthony J. Gill, Richard A. Scolyer, Anthony T. Papenfuss, Grant A. McArthur, Stephen B. Fox, Ricky W. Johnstone, David D.L. Bowtell, Shahneen Sandhu, Mark Shackleton, Meredith Johnston, Carleen Cullinane, John F. Thompson, Graham J. Mann, George Hruby, J. Helen Leonard, Andrew Fellowes, Gisela Mir Arnau, Timothy Semple, Richard Lupat, Jason Li, Ricardo De Paoli-Iseppi, Andrew J. Colebatch, James S. Wilmott, Jason Madore, Jan Schröder, Ismael A. Vergara, Kelly Waldeck, Stephen Q. Wong
Focal copy number alterations proximal to viral integrations in V+MCC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d118240471cb21a3dcf367c5dc1b565
https://doi.org/10.1158/0008-5472.22408176.v1
https://doi.org/10.1158/0008-5472.22408176.v1