Zobrazeno 1 - 10 of 231 pro vyhledávání: '"Richard, Kolesnick"'
1
Akademický článek
Acid sphingomyelinase inhibition induces cerebral angiogenesis post-ischemia/reperfusion in an oxidative stress-dependent way and promotes endothelial survival by regulating mitochondrial metabolism
Autor: Ayan Mohamud Yusuf, Mina Borbor, Tanja Hussner, Carolin Weghs, Britta Kaltwasser, Matthias Pillath-Eilers, Bernd Walkenfort, Richard Kolesnick, Erich Gulbins, Dirk M. Hermann, Ulf Brockmeier
Publikováno v: Cell Death and Disease, Vol 15, Iss 9, Pp 1-14 (2024)
Abstract Acid sphingomyelinase (ASM) inhibitors are widely used for the treatment of post-stroke depression. They promote neurological recovery in animal stroke models via neurorestorative effects. In a previous study, we found that antidepressants i
Externí odkaz: https://doaj.org/article/bb96a3a7cca44e52960359d37b31a205
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2
Akademický článek
Radiation-induced gastrointestinal (GI) syndrome as a function of age
Autor: Hongyan Li, Herman C. Kucharavy, Carla Hajj, Liyang Zhao, Guoqiang Hua, Ryan Glass, Phillip B. Paty, Zvi Fuks, Richard Kolesnick, Karen Hubbard, Adriana Haimovitz-Friedman
Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-7 (2023)
Abstract Previous studies show increased sensitivity of older mice (28–29 months) compared with young adult mice (3 months, possessing a mature immune system) to radiation-induced GI lethality. Age-dependent lethality was associated with higher lev
Externí odkaz: https://doaj.org/article/0af0995b6bde418190a8d6665f7d9f00
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4
Akademický článek
Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury
Autor: Irina Petrache, Elisabet Pujadas, Aditya Ganju, Karina A. Serban, Alexander Borowiec, Beatrice Babbs, Irina A. Bronova, Nicholas Egersdorf, Patrick S. Hume, Khushboo Goel, William J. Janssen, Evgeny V. Berdyshev, Carlos Cordon-Cardo, Richard Kolesnick
Publikováno v: JCI Insight, Vol 8, Iss 10 (2023)
The pathogenesis of the marked pulmonary microvasculature injury, a distinguishing feature of COVID-19 acute respiratory distress syndrome (COVID-ARDS), remains unclear. Implicated in the pathophysiology of diverse diseases characterized by endotheli
Externí odkaz: https://doaj.org/article/941d1f0f2b0b4a3796435b73218fab88
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6
Akademický článek
Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells
Autor: Stefan Klingler, Kuo-Shun Hsu, Guoqiang Hua, Maria Laura Martin, Mohammad Adileh, Timour Baslan, Zhigang Zhang, Philip B. Paty, Zvi Fuks, Anthony M.C. Brown, Richard Kolesnick
Publikováno v: JCI Insight, Vol 7, Iss 5 (2022)
Recent data establish a logarithmic expansion of leucine rich repeat containing G protein coupled receptor 5–positive (Lgr5+) colonic epithelial stem cells (CESCs) in human colorectal cancer (CRC). Complementary studies using the murine 2-stage azo
Externí odkaz: https://doaj.org/article/9ef3f2bee094401588a41ba8a913fa23
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8
Akademický článek
Anti-ceramide single-chain variable fragment mitigates radiation GI syndrome mortality independent of DNA repair
Autor: Jimmy A. Rotolo, Chii Shyang Fong, Sahra Bodo, Prashanth K.B. Nagesh, John Fuller, Thivashnee Sharma, Alessandra Piersigilli, Zhigang Zhang, Zvi Fuks, Vijay K. Singh, Richard Kolesnick
Publikováno v: JCI Insight, Vol 6, Iss 8 (2021)
After 9/11, threat of nuclear attack on American urban centers prompted government agencies to develop medical radiation countermeasures to mitigate hematopoietic acute radiation syndrome (H-ARS) and higher-dose gastrointestinal acute radiation syndr
Externí odkaz: https://doaj.org/article/76b420606de142dd89228218364193f3
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