Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Richard, Killick"'
Autor:
Erwin Lemche, Richard Killick, Jackie Mitchell, Paul W. Caton, Pratik Choudhary, Jane K. Howard
Publikováno v:
Neurobiology of Disease, Vol 196, Iss , Pp 106485- (2024)
Research evidence indicating common metabolic mechanisms through which type 2 diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has accumulated over recent decades. The aim of this systematic review is to provide a com
Externí odkaz:
https://doaj.org/article/c3c280316f034a86a4c98744d78acff2
Autor:
Roberto Collu, Zheng Yin, Elisa Giunti, Sarah Daley, Mei Chen, Peter Morin, Richard Killick, Stephen T. C. Wong, Weiming Xia
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionThe goal of this study is to explore the pharmacological potential of the amyloid-reducing vasodilator fasudil, a selective Ras homolog (Rho)-associated kinases (ROCK) inhibitor, in the P301S tau transgenic mouse model (Line PS19) of neur
Externí odkaz:
https://doaj.org/article/738526ed29cf4602848657bb379d4868
Autor:
Ayesha Khan, Richard Killick, Daniel Wirth, Dominique Hoogland, Kalina Hristova, Jakob P. Ulmschneider, Christopher R. King, Martin B. Ulmschneider
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract Introduction Reducing brain levels of both soluble and insoluble forms of amyloid beta (Aβ) remains the primary goal of most therapies that target Alzheimer's disease (AD). However, no treatment has so far resulted in patient benefit, and c
Externí odkaz:
https://doaj.org/article/964ff61904ec4b6b91c1f1f545a124ba
Autor:
Richard Killick, Christina Elliott, Elena Ribe, Martin Broadstock, Clive Ballard, Dag Aarsland, Gareth Williams
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11219 (2023)
The pan Rho-associated coiled-coil-containing protein kinase (ROCK) inhibitor fasudil acts as a vasodilator and has been used as a medication for post-cerebral stroke for the past 29 years in Japan and China. More recently, based on the involvement o
Externí odkaz:
https://doaj.org/article/6ef281694b6e49188979fd046f1e6899
Autor:
Eugene Kim, Davide Di Censo, Mattia Baraldo, Camilla Simmons, Ilaria Rosa, Karen Randall, Clive Ballard, Ben R. Dickie, Steven C. R. Williams, Richard Killick, Diana Cash
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Amyloid plaques are a hallmark of Alzheimer’s disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitoring of treatments, but this rema
Externí odkaz:
https://doaj.org/article/df2aaa01f2f84dd0ac1f44193b0b4812
SummaryNeuronal circuits evolve as a precisely patterned network. In this context, a growing neuron must locate the appropriate target area on a neurite of a neighbouring cell with which to connect. Controlled target selection involves dendritic filo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f81ee1a042d784e2711a46961aa529db
https://doi.org/10.1101/2023.02.17.528927
https://doi.org/10.1101/2023.02.17.528927
Autor:
Claudie Hooper, Ricardo Sainz-Fuertes, Steven Lynham, Abdul Hye, Richard Killick, Alice Warley, Cecilia Bolondi, Jennifer Pocock, Simon Lovestone
Publikováno v:
BMC Neuroscience, Vol 21, Iss 1, Pp 1-1 (2020)
Following the publication of this article [1], it has been noted by the authors that an image of the same cell nuclei has been used in error twice, in Fig. 8, parts A and B. These images are redundant in this figure as the images in parts D and E sho
Externí odkaz:
https://doaj.org/article/6b68678ddf2344dd9e189f599f0c06c0
Autor:
Jacqueline P. Robbins, Leo Perfect, Elena M. Ribe, Marcello Maresca, Adrià Dangla-Valls, Evangeline M. Foster, Richard Killick, Paulina Nowosiad, Matthew J. Reid, Lucia Dutan Polit, Alejo J. Nevado, Daniel Ebner, Mohammad Bohlooly-Y, Noel Buckley, Menelas N. Pangalos, Jack Price, Simon Lovestone
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Our understanding of the molecular processes underlying Alzheimer’s disease (AD) is still limited, hindering the development of effective treatments, and highlighting the need for human-specific models. Advances in identifying components of the amy
Externí odkaz:
https://doaj.org/article/cbd88ea3b15f4424a992edf8c0d98186
Autor:
Richard Killick, Christina Elliott, Elena Ribe, Martin Broadstock, Clive Ballard, Dag Aarsland, Gareth Williams
The pan ROCK inhibitor fasudil acts as a vasodilator and has been used as a medication post cerebral stroke for the past 27 years in Japan and China. More recently, on the basis of the involvement of ROCK inhibition on synaptic function, neuronal sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::249f0325c8a8af1833f479790012797f
https://doi.org/10.1101/2022.09.30.510301
https://doi.org/10.1101/2022.09.30.510301
Publikováno v:
Free radical biologymedicine. 193(Pt 1)
The birth of new neurons from neural stem cells (NSC)s during developmental and adult neurogenesis arises from a myriad of highly complex signalling cascades. Emerging as one of these is the nuclear factor erythroid 2-related factor (NRF2)-signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d4f0bd7d8a426ea04f8fdd30a813b5
https://pubmed.ncbi.nlm.nih.gov/36272667
https://pubmed.ncbi.nlm.nih.gov/36272667