Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Richard, Iggo"'
Autor:
Noémie Pied, Coralie F Daussy, Zoé Denis, Jessica Ragues, Muriel Faure, Richard Iggo, Mario P Tschan, Benoit Roger, Fabienne Rayne, Harald Wodrich
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010736 (2022)
Intracellular pathogens cause membrane distortion and damage as they enter host cells. Cells perceive these membrane alterations as danger signals and respond by activating autophagy. This response has primarily been studied during bacterial invasion
Externí odkaz:
https://doaj.org/article/78bc06bead7543b6956fd66c5d713739
Autor:
Matthieu Lewis, Valérie Prouzet‐Mauléon, Florence Lichou, Elodie Richard, Richard Iggo, Béatrice Turcq, François‐Xavier Mahon
Publikováno v:
Cancer Medicine, Vol 9, Iss 18, Pp 6739-6751 (2020)
Abstract Understanding resistance mechanisms in cancer is of utmost importance for the discovery of novel “druggable” targets. Efficient genetic screening, now even more possible with CRISPR‐Cas9 gene‐editing technology, next‐generation seq
Externí odkaz:
https://doaj.org/article/ee2e1b61d9ac4c1882f8c1d944da62fe
Autor:
Céline Gounou, Flora Bouvet, Benjamin Liet, Valérie Prouzet‐Mauléon, Léna d'Agata, Etienne Harté, Françoise Argoul, Géraldine Siegfried, Richard Iggo, Abdel‐Majid Khatib, Anthony Bouter
Publikováno v:
Biology of the Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2957c1cd152502b1f656d6a325b8543
https://doi.org/10.1111/boc.202200110
https://doi.org/10.1111/boc.202200110
Autor:
Georges Vassaux, Kevin Harrington, Nick R. Lemoine, Richard Iggo, Mohan Hingorani, Miguel Quintanilla, Jerome Burnet, Cécilia Hindorf, Pilar Martin-Duque, Sophie Conchon, Patrick Baril, Andrew Merron, Inge Peerlinck
Purpose: The Na/I symporter (hNIS) promotes concentration of iodine in cells. In cancer gene therapy, this transgene has potential as a reporter gene for molecular imaging of viral biodistribution and as a therapeutic protein promoting 131I-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c93db3c809aec6703a14133fda6ac6
https://doi.org/10.1158/1078-0432.c.6517387.v1
https://doi.org/10.1158/1078-0432.c.6517387.v1
Autor:
Thierry Soussi, Pierre Hainaut, Peter E.M. Taschner, Joseph F. Fraumeni, Thorsten Zenz, Robert Zeillinger, Patricia N. Tonin, Louise C. Strong, Sharon A. Savage, Davide Rossi, Patricia Ashton-Prolla, Sarka Pospisilova, Kim E. Nichols, Jeffrey N. Myers, Ute M. Moll, David Malkin, Phuong L. Mai, Jacqueline Lehmann-Che, Richard Iggo, Eva Hellstrom-Lindberg, Anita Langerød, Gianluca Gaidano, Pierre Fenaux, Wafik S. El-Deiry, Lawrence A. Donehower, Nicole Concin, Antony Braithwaite, Gareth L. Bond, Fanny Baran-Marszak, Mandy L. Ballinger, Bernard Leroy
Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li–Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy. Genomic data from m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287bd11319667648ab1c91bba0bb64f3
https://doi.org/10.1158/0008-5472.c.6509369
https://doi.org/10.1158/0008-5472.c.6509369
Autor:
Georges Vassaux, Kevin Harrington, Nick R. Lemoine, Richard Iggo, Mohan Hingorani, Miguel Quintanilla, Jerome Burnet, Cécilia Hindorf, Pilar Martin-Duque, Sophie Conchon, Patrick Baril, Andrew Merron, Inge Peerlinck
Supplementary Data from Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3931bc61633534a806eb9a8bc68967f1
https://doi.org/10.1158/1078-0432.22440007.v1
https://doi.org/10.1158/1078-0432.22440007.v1
Autor:
Marion Chapellier, Elodie Bachelard-Cascales, Xenia Schmidt, Flora Clément, Isabelle Treilleux, Emmanuel Delay, Alexandre Jammot, Christine Ménétrier-Caux, Gaëtan Pochon, Roger Besançon, Thibault Voeltzel, Claude Caron de Fromentel, Christophe Caux, Jean-Yves Blay, Richard Iggo, Véronique Maguer-Satta
Publikováno v:
Stem Cell Reports, Vol 4, Iss 2, Pp 239-254 (2015)
Understanding the mechanisms of cancer initiation will help to prevent and manage the disease. At present, the role of the breast microenvironment in transformation remains unknown. As BMP2 and BMP4 are important regulators of stem cells and their ni
Externí odkaz:
https://doaj.org/article/c138339f781b4b7fbe5c2cdc183ec47e
Autor:
Céline Gounou, Flora Bouvet, Léna d'Agata, Marie-Alix Derieppe, Lucile Rouyer, Léa Bouton, Mailys Mélane, Dorian Chapeau, Etienne Harté, Julie Martineau, Valerie Prouzet-Mauleon, Sisareuth Tan, Wilfried Souleyreau, Frederic Saltel, Francoise Argoul, Geraldine Siegfried, Abdel-Majid Khatib, Alain Brisson, Richard Iggo, Anthony Bouter
Cancer cells are exposed to major compressive and shearing forces during invasion and metastasis, leading to extensive plasma membrane damage. To survive this mechanical stress, they need to repair membrane injury efficiently. Targeting the membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42f54739a09955ac2601b6a811686975
https://doi.org/10.21203/rs.3.rs-2252278/v1
https://doi.org/10.21203/rs.3.rs-2252278/v1
Autor:
Raj Shrestha, Zeyad D. Nassar, Adrienne R. Hanson, Richard Iggo, Scott L. Townley, Jonas Dehairs, Chui Yan Mah, Madison Helm, Mohammadreza Ghodsi, Marie Pickering, Matthew J. Watt, Lake-Ee Quek, Andrew J. Hoy, Wayne D. Tilley, Johannes V. Swinnen, Lisa M. Butler, Luke A. Selth
Prostate tumours are highly reliant on lipids for energy, growth and survival. Activity of the androgen receptor (AR) is associated with reprogramming of lipid metabolic processes in prostate cancer, although the molecular underpinnings of this relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25804b56528ab2574ca6a62d8a225275
https://doi.org/10.1101/2022.10.13.511039
https://doi.org/10.1101/2022.10.13.511039
Autor:
Geraldine Laven-Law, Wilbert Zwart, Tarek M. A. Abdel-Fatah, Theresa E. Hickey, Mun N. Hui, Sarah Alexandrou, Luke A. Selth, Kee Ming Chia, Ian O. Ellis, C. Elizabeth Caldon, Daniel L. Roden, Jessica Finlay-Schultz, Suzan Stelloo, Shalini Jindal, Alexander Swarbrick, Wayne D. Tilley, Stephen N. Birrell, Carol A. Sartorius, Heloisa Helena Milioli, Richard Iggo, Carlo Palmieri, Esmaeil Ebrahimie, Jason S. Carroll, Elgene Lim
Publikováno v:
Nature Medicine, 27, pp. 310-320
Nature Medicine, 27, 310-320
NATURE MEDICINE
Nature Medicine, 27, 310-320
NATURE MEDICINE
The role of the androgen receptor (AR) in estrogen receptor (ER)-α-positive breast cancer is controversial, constraining implementation of AR-directed therapies. Using a diverse, clinically relevant panel of cell-line and patient-derived models, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba0daa407197cbaf1a818ceffe24eb8
https://doi.org/10.1038/s41591-020-01168-7
https://doi.org/10.1038/s41591-020-01168-7