Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Richard, Graeff"'
Publikováno v:
Molecules, Vol 26, Iss 23, p 7165 (2021)
Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the N1-ribosylated, Ca2+-mobilizing, s
Externí odkaz:
https://doaj.org/article/a4b277117732405ca369cdbf4afde384
Autor:
Richard Graeff, Alonso Guedes, Ruth Quintana, Erin Wendt-Hornickle, Caroline Baldo, Timothy Walseth, Scott O’Grady, Mathur Kannan
Publikováno v:
Molecules, Vol 25, Iss 21, p 4966 (2020)
Adenosine and uric acid (UA) play a pivotal role in lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). In the present experiments, we measured adenosine synthesis from nicotinamide adenine dinucleotide (NAD+) in membranes
Externí odkaz:
https://doaj.org/article/a27376f9022345f2be5c353c81bd1b94
Autor:
Deepak A. Deshpande, Alonso G. P. Guedes, Richard Graeff, Soner Dogan, Subbaya Subramanian, Timothy F. Walseth, Mathur S. Kannan
Publikováno v:
Mediators of Inflammation, Vol 2018 (2018)
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness. Inflammatory cytokines alter calcium (Ca2+) signaling an
Externí odkaz:
https://doaj.org/article/12bcfa8a66464e6d80360e70221c00b4
Autor:
Christelle Moreau, Qun Liu, Richard Graeff, Gerd K Wagner, Mark P Thomas, Joanna M Swarbrick, Satoshi Shuto, Hon Cheung Lee, Quan Hao, Barry V L Potter
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66247 (2013)
Few inhibitors exist for CD38, a multifunctional enzyme catalyzing the formation and metabolism of the Ca(2+)-mobilizing second messenger cyclic adenosine 5'-diphosphoribose (cADPR). Synthetic, non-hydrolyzable ligands can facilitate structure-based
Externí odkaz:
https://doaj.org/article/77d1703fdf0f48198e3453cdbaee4027
Autor:
Joanna M, Swarbrick, Richard, Graeff, Hongmin, Zhang, Mark P, Thomas, Quan, Hao, Barry V L, Potter
Publikováno v:
Journal of Medicinal Chemistry
Cyclic adenosine 5′-diphosphate ribose (cADPR) analogs based on the cyclic inosine 5′-diphosphate ribose (cIDPR) template were synthesized by recently developed stereo- and regioselective N1-ribosylation. Replacing the base N9-ribose with a butyl
Publikováno v:
Biochemistry. 47(52)
First identified on the surface of lymphoids as a type II transmembrane protein, CD38 has now been established to have dual functions not only as a receptor but also as a multifunctional enzyme, catalyzing the synthesis of and hydrolysis of a general
Autor:
Michael L, Love, Doletha M E, Szebenyi, Irina A, Kriksunov, Daniel J, Thiel, Cyrus, Munshi, Richard, Graeff, Hon Cheung, Lee, Quan, Hao
Publikováno v:
Structure (London, England : 1993). 12(3)
ADP-ribosyl cyclase catalyzes the elimination of nicotinamide from NAD and cyclization to cADPR, a known second messenger in cellular calcium signaling pathways. We have determined to 2.0 A resolution the structure of Aplysia cyclase with ribose-5-ph
Publikováno v:
Journal of Physical Chemistry B; Nov2008, Vol. 112 Issue 47, p14682-14686, 5p
Autor:
Wei W; Wenjie Wei, Richard Graeff, Jianbo Yue, Department of Physiology, the University of Hong Kong, Hong Kong, China., Graeff R; Wenjie Wei, Richard Graeff, Jianbo Yue, Department of Physiology, the University of Hong Kong, Hong Kong, China., Yue J; Wenjie Wei, Richard Graeff, Jianbo Yue, Department of Physiology, the University of Hong Kong, Hong Kong, China.
Publikováno v:
World journal of biological chemistry [World J Biol Chem] 2014 Feb 26; Vol. 5 (1), pp. 58-67.