Zobrazeno 1 - 10
of 411
pro vyhledávání: '"Richard, Foster"'
Autor:
Emma Brown, Gemma Swinscoe, Daniella A Lefteri, Ravi Singh, Amy Moran, Rebecca F Thompson, Daniel Maskell, Hannah Beaumont, Matthew J Bentham, Claire Donald, Alain Kohl, Andrew Macdonald, Neil Ranson, Richard Foster, Clive S McKimmie, Antreas C Kalli, Stephen Griffin
Publikováno v:
eLife, Vol 13 (2024)
Flaviviruses, including Zika virus (ZIKV), are a significant global health concern, yet no licensed antivirals exist to treat disease. The small membrane (M) protein plays well-defined roles during viral egress and remains within virion membranes fol
Externí odkaz:
https://doaj.org/article/2ea2a660429141029618f43cf5ee6d6c
Autor:
Thomas L. Williams, Duuamene Nyimanu, Rhoda E. Kuc, Richard Foster, Robert C. Glen, Janet J. Maguire, Anthony P. Davenport
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Pulmonary arterial hypertension (PAH) is characterised by endothelial dysfunction and pathological vascular remodelling, resulting in the occlusion of pulmonary arteries and arterioles, right ventricular hypertrophy, and eventually fata
Externí odkaz:
https://doaj.org/article/96d17a331f9240c6a1914d929b042de1
Autor:
Katherine Norman, Karen E Hemmings, Heba Shawer, Hollie L Appleby, Alan J Burnett, Nurasyikin Hamzah, Rajendra Gosain, Emily M Woodhouse, David J Beech, Richard Foster, Marc A Bailey
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0296065 (2024)
Calcium (Ca2+) is a key second messenger in eukaryotes, with store-operated Ca2+ entry (SOCE) being the main source of Ca2+ influx into non-excitable cells. ORAI1 is a highly Ca2+-selective plasma membrane channel that encodes SOCE. It is ubiquitousl
Externí odkaz:
https://doaj.org/article/9a32393d1f0845708635e76c1981aa12
Autor:
Richard S. Finkel, Monique M. Ryan, Samuel Ignacio Pascual Pascual, John W. Day, Eugenio Mercuri, Darryl C. De Vivo, Richard Foster, Jacqueline Montes, Juliana Gurgel‐Giannetti, Drew MacCannell, Zdenek Berger
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 6, Pp 819-829 (2022)
Abstract Objective The long‐term favorable safety profile of nusinersen provides an opportunity to consider a higher dose. We report on the relationships between nusinersen cerebrospinal fluid (CSF) exposure, biomarker levels, and clinical efficacy
Externí odkaz:
https://doaj.org/article/0511be6ebada4f91a7caec4dbaa8c369
Autor:
Yong Xu, Roberto Maya-Martinez, Nicolas Guthertz, George R. Heath, Iain W. Manfield, Alexander L. Breeze, Frank Sobott, Richard Foster, Sheena E. Radford
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here the authors carry out chemical kinetic studies revealing that aggregation of hIAPP and its variant S20G involves secondary nucleation. Two small molecules with novel scaffolds are shown to inhibit or accelerate aggregation by binding different m
Externí odkaz:
https://doaj.org/article/d21098cc865040188a3674711bd2d77e
Autor:
Samantha L. Heal, Lewis J. Hardy, Clare L. Wilson, Majid Ali, Robert A. S. Ariëns, Richard Foster, Helen Philippou
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 4, Pp n/a-n/a (2022)
Abstract Background Evidence of crosstalk between the complement and coagulation cascades exists, and dysregulation of either pathway can lead to serious thromboinflammatory events. Both the intrinsic pathway of coagulation and the alternative pathwa
Externí odkaz:
https://doaj.org/article/31be32eb4b86439ab4a72e9bd3be79bf