Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Richard, Chesworth"'
Autor:
Joshua S. Alford, John W. Lampe, Dorothy Brach, Richard Chesworth, Kat Cosmopoulos, Kenneth W. Duncan, Sean T. Eckley, Jeffrey L. Kutok, Alejandra Raimondi, Thomas V. Riera, Brian Shook, Cuyue Tang, Jennifer Totman, Neil A. Farrow
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1137-1143
SETD2, a lysine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0923d93af3913acf097ff9afc7c6e1
https://doi.org/10.1021/acsmedchemlett.2c00167
https://doi.org/10.1021/acsmedchemlett.2c00167
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
XLSX file - 132K, Table S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5ead92a929cc4e895624b9120695df
https://doi.org/10.1158/1535-7163.22499889.v1
https://doi.org/10.1158/1535-7163.22499889.v1
Autor:
Scott A. Ribich, Heike Keilhack, Jesse J. Smith, Richard Chesworth, Robert A. Copeland, Peter Ho, John Campbell, Maria Roche, Kristy Kuplast-Barr, Sarah K. Knutson, Igor Feldman, Alexandra R. Grassian, Allison Drew, Kelli Armstrong, Elayne Chan-Penebre
The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit mutations across virtually all cancer types. We previously reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f0193e841ebe292cdd7fd3a4087a01
https://doi.org/10.1158/1535-7163.c.6537771.v1
https://doi.org/10.1158/1535-7163.c.6537771.v1
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 811K, Fig. S1. Effects of EPZ-6438 on Gene Promoter H3K27 Methylation, Recruitment of PRC2 Components to Gene Promoters, and Cell Cycle, in WSU-DLCL2 Cells. Fig. S2: Effects of EPZ-6438 on Gene Expression in EZH2 Mutant Lymphoma Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fcbfa5d3e9bdddeac3c8f600a70bce
https://doi.org/10.1158/1535-7163.22499898.v1
https://doi.org/10.1158/1535-7163.22499898.v1
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
PDF file - 25K, Table S1: LCC Values for EPZ-6438 for WSU-DLCL2 Human Lymphoma Cells Dosed Either Continuously or After Compound Washout.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12304f9a85f43c2b5fe15a51c85b039b
https://doi.org/10.1158/1535-7163.22499892
https://doi.org/10.1158/1535-7163.22499892
Autor:
Heike Keilhack, Akira Yokoi, Kevin W. Kuntz, Roy M. Pollock, Toshimitsu Uenaka, Victoria M. Richon, Robert A. Copeland, Mikel P. Moyer, Richard Chesworth, Margaret Porter-Scott, Jesse J. Smith, Nigel J. Waters, Alejandra Raimondi, Christina J. Allain, Christine R. Klaus, Tim J. Wigle, Namita Kumar, Galina Kuznetsov, Mai Uesugi, Tadashi Kadowaki, Yonghong Xiao, Kuan-Chun Huang, Natalie M. Warholic, Yukinori Minoshima, Satoshi Kawano, Sarah K. Knutson
Mutations within the catalytic domain of the histone methyltransferase EZH2 have been identified in subsets of patients with non-Hodgkin lymphoma (NHL). These genetic alterations are hypothesized to confer an oncogenic dependency on EZH2 enzymatic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9ced2f5eb38e4c70192dc2fd63ef50
https://doi.org/10.1158/1535-7163.c.6536301
https://doi.org/10.1158/1535-7163.c.6536301
Autor:
Scott A. Ribich, Heike Keilhack, Jesse J. Smith, Richard Chesworth, Robert A. Copeland, Peter Ho, John Campbell, Maria Roche, Kristy Kuplast-Barr, Sarah K. Knutson, Igor Feldman, Alexandra R. Grassian, Allison Drew, Kelli Armstrong, Elayne Chan-Penebre
PDF File -1 MB, Supplemental data is to further support the statements made it the main text. Captions: Supplemental Table 1: Cell Lines used in the CRISPR pooled screen. Supplemental Table 2: Table of ovarian lines screened for tazemetostat sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28078359a52e1425c550d2baf2f9465b
https://doi.org/10.1158/1535-7163.22504545
https://doi.org/10.1158/1535-7163.22504545
Autor:
Michael J Thomenius, Jennifer Totman, Darren Harvey, Lorna H Mitchell, Thomas V Riera, Kat Cosmopoulos, Alexandra R Grassian, Christine Klaus, Megan Foley, Elizabeth A Admirand, Haris Jahic, Christina Majer, Tim Wigle, Suzanne L Jacques, Jodi Gureasko, Dorothy Brach, Trupti Lingaraj, Kip West, Sherri Smith, Nathalie Rioux, Nigel J Waters, Cuyue Tang, Alejandra Raimondi, Michael Munchhof, James E Mills, Scott Ribich, Margaret Porter Scott, Kevin W Kuntz, William P Janzen, Mikel Moyer, Jesse J Smith, Richard Chesworth, Robert A Copeland, P Ann Boriack-Sjodin
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)
A key challenge in the development of precision medicine is defining the phenotypic consequences of pharmacological modulation of specific target macromolecules. To address this issue, a variety of genetic, molecular and chemical tools can be used. A
Externí odkaz:
https://doaj.org/article/8d24a066e3c44272bf8a8c8842bb3428
Autor:
Michael J Morrison, P Ann Boriack-Sjodin, Kerren K Swinger, Tim J Wigle, Dipti Sadalge, Kevin W Kuntz, Margaret Porter Scott, William P Janzen, Richard Chesworth, Kenneth W Duncan, Darren M Harvey, John W Lampe, Lorna H Mitchell, Robert A Copeland
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197082 (2018)
WHSC1 is a histone methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3 and has been implicated as a driver in a variety of hematological and solid tumors. Currently, there is a complete lack of validated chemi
Externí odkaz:
https://doaj.org/article/5a738d78cc0446bf85ca79bb119bc45d
Autor:
Igor Feldman, Elayne Chan-Penebre, Alexandra R. Grassian, Kelli A. Armstrong, Kristy Kuplast-Barr, John Campbell, Sarah K. Knutson, Heike Keilhack, Maria Roche, Peter T.C. Ho, Scott Ribich, J. Joshua Smith, Robert A. Copeland, Richard Chesworth, Allison Drew
Publikováno v:
Molecular Cancer Therapeutics. 16:850-860
The SWI/SNF complex is a major regulator of gene expression and is increasingly thought to play an important role in human cancer, as evidenced by the high frequency of subunit mutations across virtually all cancer types. We previously reported that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::747f40bb502acb9ed4d112bf0f390043
https://doi.org/10.1158/1535-7163.mct-16-0678
https://doi.org/10.1158/1535-7163.mct-16-0678