Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Richard, Bundey"'
Autor:
Jason D. Jacintho, Richard Bundey, Nicholas Simon Stock, Alex R. Broadhead, Karin J. Stebbins, Austin Chen, Ryan C. Clark, Lucia Correa, Yalda Bravo, Christopher Baccei, Peppi Prasit, Davorka Messmer, Daniel S. Lorrain
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2267-2272
The discovery and SAR of a novel series of potent and selective PPARα antagonists are herein described. Exploration of replacements for the labile acyl sulfonamide linker led to a biaryl sulfonamide series of which compound 33 proved to be suitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0831ca0312667de4945e3418afd1045
https://doi.org/10.1016/j.bmcl.2014.03.090
https://doi.org/10.1016/j.bmcl.2014.03.090
Autor:
Peppi Prasit, Daniel S. Lorrain, Davorka Messmer, Karin J. Stebbins, Lucia Correa, Austin Chen, Richard Bundey, Geraldine Cabrera, Alex R. Broadhead, Nicholas Simon Stock, Christopher Baccei, Yalda Bravo
Publikováno v:
European journal of pharmacology. 809
Peroxisome-proliferator activated receptors (PPAR) are members of the nuclear hormone receptor superfamily which regulate gene transcription. PPARα is a key regulator of lipid homeostasis and a negative regulator of inflammation. Under conditions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d81a51b31cebff203d417e655669f24
https://pubmed.ncbi.nlm.nih.gov/28483457
https://pubmed.ncbi.nlm.nih.gov/28483457
Autor:
Thomas, Toneff, Liane, Mende-Mueller, Ying, Wu, Shin-Rong, Hwang, Richard, Bundey, Leslie M, Thompson, Marie-Francoise, Chesselet, Vivian, Hook
Publikováno v:
Journal of neurochemistry. 82(1)
Proteolytic fragments of huntingtin (htt) in human lymphoblast cell lines from HD and control cases were compared to those in human HD striatal and cortical brain regions, by western blots with epitope-specific antibodies. HD lymphoblast cell lines w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b04c7bb11bf8628ff0987a4f3193b9dc
https://pubmed.ncbi.nlm.nih.gov/12091468
https://pubmed.ncbi.nlm.nih.gov/12091468
Autor:
Vivian Y H, Hook, Thomas, Toneff, Wade, Aaron, Sukkid, Yasothornsrikul, Richard, Bundey, Terry, Reisine
Publikováno v:
Journal of neurochemistry. 81(2)
A key factor in Alzheimer's disease (AD) is the beta-secretase activity that is required for the production of beta-amyloid (Abeta) peptide from its amyloid precursor protein (APP) precursor. In this study, the majority of Abeta secretion from neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06257d1599d52904f048362153c140ed
https://pubmed.ncbi.nlm.nih.gov/12064471
https://pubmed.ncbi.nlm.nih.gov/12064471
Publikováno v:
Journal of neurochemistry. 69(5)
We have previously demonstrated that corticotrophin-releasing factor receptor 1 (CRF-R1) mRNA levels can be down-regulated via activation of the cyclic AMP pathway in CATH.a cells, a neuronal cell line. In this study, we show evidence for down-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a279a6e161f2fcdc12cbc3258e5809a
https://pubmed.ncbi.nlm.nih.gov/9349535
https://pubmed.ncbi.nlm.nih.gov/9349535
Autor:
Richard Bundey, Davorka Messmer, Peppi Prasit, Geraldine Cabrera, Jason D. Jacintho, Yalda Bravo, Michael M Poon, Nicholas Simon Stock, Daniel S. Lorrain, Kymmy Lorrain, Austin Chen, Lucia Correa, Karin J. Stebbins, David Spaner
Publikováno v:
Blood. 120:3879-3879
Abstract 3879 Tumor-specific metabolic changes could serve as new therapeutic targets. While much attention has been given to the metabolism of glucose in cancer cells and intervening therapies, relatively little attention has been given to fatty aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04a1f67444471f465aae6b7e4ca5a1ff
https://doi.org/10.1182/blood.v120.21.3879.3879
https://doi.org/10.1182/blood.v120.21.3879.3879