Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Richard, Angell"'
Autor:
Ahmed Abdullah Ahmed, Shuang Chen, Maria Roman-Escorza, Richard Angell, Sally Oxenford, Matthew McConville, Naomi Barton, Mihiro Sunose, Dan Neidle, Shozeb Haider, Tariq Arshad, Stephen Neidle
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The tetrasubstituted naphthalene diimide compound QN-302 binds to G-quadruplex (G4) DNA structures. It shows high potency in pancreatic ductal adenocarcinoma (PDAC) cells and inhibits the transcription of cancer-related genes in these cells
Externí odkaz:
https://doaj.org/article/6e2ed99e2cc7475b8ea3594c22ec910c
Autor:
Bess Yi Kun Yu, Maria-Armineh Tossounian, Stefan Denchev Hristov, Ryan Lawrence, Pallavi Arora, Yugo Tsuchiya, Sew Yeu Peak-Chew, Valeriy Filonenko, Sally Oxenford, Richard Angell, Jerome Gouge, Mark Skehel, Ivan Gout
Publikováno v:
Redox Biology, Vol 44, Iss , Pp 101978- (2021)
The metastasis suppressor protein NME1 is an evolutionarily conserved and multifunctional enzyme that plays an important role in suppressing the invasion and metastasis of tumour cells. The nucleoside diphosphate kinase (NDPK) activity of NME1 is wel
Externí odkaz:
https://doaj.org/article/1a888cb0c73e41febf4761fac8db29c6
Autor:
Grace Q. Gong, Benoit Bilanges, Ben Allsop, Glenn R. Masson, Victoria Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len R. Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger L. Williams, Bart Vanhaesebroeck
Publikováno v:
Nature. 618:159-168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f8e36156cc591a3aec34b2fffc9688
https://doi.org/10.1038/s41586-023-05972-2
https://doi.org/10.1038/s41586-023-05972-2
Autor:
Federica Riccio, Sandeep K. Talapatra, Sally Oxenford, Richard Angell, Michela Mazzon, Frank Kozielski
Publikováno v:
Biology Open, Vol 8, Iss 1 (2019)
Members of the Flaviviridae family constitute a severe risk to human health. Whilst effective drugs have been developed against the hepacivirus HCV, no antiviral therapy is currently available for any other viruses, including the flaviviruses dengue
Externí odkaz:
https://doaj.org/article/7ebbf2718c8a46fb9e0fe59acf380169
Autor:
David H Drewry, Carrow I Wells, David M Andrews, Richard Angell, Hassan Al-Ali, Alison D Axtman, Stephen J Capuzzi, Jonathan M Elkins, Peter Ettmayer, Mathias Frederiksen, Opher Gileadi, Nathanael Gray, Alice Hooper, Stefan Knapp, Stefan Laufer, Ulrich Luecking, Michael Michaelides, Susanne Müller, Eugene Muratov, R Aldrin Denny, Kumar S Saikatendu, Daniel K Treiber, William J Zuercher, Timothy M Willson
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181585 (2017)
Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human protein kinases remains unknown. We have developed physical and virtual collections of small
Externí odkaz:
https://doaj.org/article/ca1842e46c3c4d9282fcf8bc425a50a8
Autor:
Michela Mazzon, Ana Maria Ortega-Prieto, Douglas Imrie, Christin Luft, Lena Hess, Stephanie Czieso, Joe Grove, Jessica Katy Skelton, Laura Farleigh, Joachim J. Bugert, Edward Wright, Nigel Temperton, Richard Angell, Sally Oxenford, Michael Jacobs, Robin Ketteler, Marcus Dorner, Mark Marsh
Publikováno v:
Viruses, Vol 11, Iss 2, p 176 (2019)
Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised awareness that infections can spread rapidly before vaccines or specific antagonists can be made a
Externí odkaz:
https://doaj.org/article/a8a22de4d5bc47b2aace70eda318bf5b
Autor:
Tam Vo, W. David Wilson, Richard Angell, Sally Oxenford, Stephan A. Ohnmacht, Chiara Marchetti, Stephen Neidle
Publikováno v:
ACS Med Chem Lett
[Image: see text] Interactions are reported of three representative naphthalenediimide derivatives with three quadruplex targets, from the promoter region of the telomerase (hTERT) gene, a human telomeric DNA quadruplex, and a telomeric RNA quadruple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c13f69f2f2a99182a28ec4d39b9d631
https://doi.org/10.1021/acsmedchemlett.0c00041
https://doi.org/10.1021/acsmedchemlett.0c00041
Autor:
Bess Yi Kun Yu, Maria-Armineh Tossounian, Stefan Denchev Hristov, Pallavi Arora, Yugo Tsuchiyaugo, Sew Yeu Peak-Chew, Sally Oxenford, Richard Angell, Jerome Gouge, Mark Skehel, Ivan Gout
Publikováno v:
Free Radical Biology and Medicine. 189:16-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a4f89bdaeaaabd10ad308a60623dd44
https://doi.org/10.1016/j.freeradbiomed.2022.06.081
https://doi.org/10.1016/j.freeradbiomed.2022.06.081
Publikováno v:
Cancer Research. 82:4069-4069
The compound SOP1812, a tetra-substituted naphthalene diimide derivative has been previously disclosed to have single-digit nM anti-proliferative activity in a panel of human pancreatic ductal adenocarcinoma (PDAC) cell lines (Ahmed et al., ACS Med C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45003f91b7d4b808d92ac87205a32a7
https://doi.org/10.1158/1538-7445.am2022-4069
https://doi.org/10.1158/1538-7445.am2022-4069
Autor:
Thomas G Fowler, Sally Oxenford, Mihiro Sunose, Jenny Worthington, Tam Vo, Richard Angell, Saadia A. Karim, Stephen Neidle, Matthew Mcconville, Naomi Barton, Ahmed A. Ahmed, Nicole Williams, W. David Wilson, Jennifer P. Morton, Daniel E O'Flynn
Publikováno v:
ACS Med Chem Lett
[Image: see text] Targeting of genomic quadruplexes is an approach to treating complex human cancers. We describe a series of tetra-substituted naphthalene diimide (ND) derivatives with a phenyl substituent directly attached to the ND core. The lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75540ebe7ac401c6610e70891565425
https://pubmed.ncbi.nlm.nih.gov/32832034
https://pubmed.ncbi.nlm.nih.gov/32832034