Clinical and mutational profile of AT-rich interaction domain 1A-mutated cancers

Autor: Rosa Falcone, Marco Filetti, Pasquale Lombardi, Valeria Altamura, Francesco Paroni Sterbini, Giovanni Scambia, Gennaro Daniele

Publikováno v: Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 4, Pp 716-726 (2023)

Aim: AT-rich interaction domain 1A (ARID1A) encodes a key component of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex that participates in gene expression. ARID1A alterations are quite common among cancer patients, although

Externí odkaz: https://doaj.org/article/332642ff24084277bee380049cb3eabb

Downregulated ARID1A by miR-185 Is Associated With Poor Prognosis and Adverse Outcomes in Colon Adenocarcinoma

Autor: Salem Baldi, Hassan Khamgan, Yuanyuan Qian, Han Wu, Zhenyu Zhang, Mengyan Zhang, Yina Gao, Mohammed Safi, Mohammed Al-Radhi, Yun-Fei Zuo

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

AT-rich interaction domain 1A (ARID1A) is a tumor suppressor gene that mutates in several cancer types, including breast cancer, ovarian cancer, and colorectal cancer (CRC). In colon adenocarcinoma (COAD), the low expression of ARID1A was reported bu

Externí odkaz: https://doaj.org/article/df1e54adeb994011ab113c37d3ccf552

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Immune evasion by cancer stem cells

Autor: Goshi Shiota, Hiroyuki Tsuchiya

Publikováno v: Tsuchiya, Hiroyuki. Shiota, Goshi. Immune evasion by cancer stem cells. Regenerative Therapy. 17. 20-33. doi:10.1016/j.reth.2021.02.006
Regenerative Therapy, Vol 17, Iss, Pp 20-33 (2021)
Regenerative Therapy

Tumor immunity represents a new avenue for cancer therapy. Immune checkpoint inhibitors have successfully improved outcomes in several tumor types. In addition, currently, immune cell-based therapy is also attracting significant attention. However, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6054a82a446a6f8b0b1100401e59a6
https://doi.org/10.1016/j.reth.2021.02.006