Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Rich B. Meyer"'
Autor:
Arjang Hassibi, Gregory Dolganov, Kirsten A. Johnson, Edmond Ku, Peter Kuimelis, Nader Gamini, Babak Hassibi, Pejman Naraghi-Arani, Yuan Li, Mehrdad Heshami, Lei Pei, Nicholas Wood, Luc J. Bousse, Ritu Raj Singh, Gelareh Mazarei, Pallavi Mantina, Haris Vikalo, Ruma Sinha, Sara Bolouki, Scott Conradson, Mark W. McDermott, Kshama Jirage, Arun Manickam, Robert G. Kuimelis, Benjamin A. Pinsky, Michael P. Savage, Piyush Savalia, Mark A. Miller, Jessica Ebert, Michael T Taylor, Tran Van, Rich B Meyer, Patrick Grogan, Gary K. Schoolnik
The emergence of pathogens resistant to existing antimicrobial drugs is a growing worldwide health crisis that threatens a return to the pre-antibiotic era. To decrease the overuse of antibiotics, molecular diagnostics systems are needed that can rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5114a8a46338e1fc4f91c68ca51f87
https://resolver.caltech.edu/CaltechAUTHORS:20180723-095009655
https://resolver.caltech.edu/CaltechAUTHORS:20180723-095009655
Publikováno v:
Nucleic Acids Research. 27:2931-2937
Triplex-forming oligonucleotides (TFOs) bind sequence-specifically in the major groove of double-stranded DNA. Cyclopropapyrroloindole (CPI), the electrophilic moiety that comprises the reactive subunit of the antibiotic CC-1065, gives hybridization-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da64a9a17624576412696a2d78cc7f8d
https://doi.org/10.1093/nar/27.14.2931
https://doi.org/10.1093/nar/27.14.2931
Publikováno v:
Journal of the American Chemical Society. 120:9729-9734
Triplex-forming oligonucleotides (TFOs) bind in the major groove to specific double-helical DNA sequences and have been shown to inhibit the function of targeted genes. Diaziridinylquinones are bifunctional alkylating agents that can form interstrand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a35d655848456c98ad97a4932b12177
https://doi.org/10.1021/ja973819u
https://doi.org/10.1021/ja973819u
Autor:
Irina A. Afonina, Michael W. Reed, Howard Gamper, Rich B. Meyer, Alexander A. Gall, Robert M. Wydro, Evgeniy S. Belousov, Igor V. Kutyavin
Publikováno v:
Nucleic Acids Research. 26:1324-1328
A 12 nucleotide oligodeoxyribopurine tract in the gene for the chemokine receptor CCR5 has been targeted and covalently modified in intact cells by a 12mer triplex forming oligonucleotide (TFO) bearing a reactive group. A nitrogen mustard placed on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d509891433d12468a71b237d3e6e95c6
https://doi.org/10.1093/nar/26.5.1324
https://doi.org/10.1093/nar/26.5.1324
Autor:
Michael W. Reed, and Ansel Wald, Eugeny A. Lukhtanov, Alexander A. Gall, Vladimir V. Gorn, Igor V. Kutyavin, Rich B. Meyer
Publikováno v:
Bioconjugate Chemistry. 9:64-71
A versatile method is described for preparing aryl nitrogen mustard-oligodeoxyribonucleotide (mustard-ODN) conjugates under anhydrous conditions. The chemistry uses DMSO soluble triethylammonium or tributylammonium salts of the ODNs. A G/A motif trip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97e74a05046eb72526bb14db7ec125e
https://doi.org/10.1021/bc970134a
https://doi.org/10.1021/bc970134a
Autor:
Howard Gamper, Rich B. Meyer, Michael W. Reed, Igor V. Kutyavin, Rebecca L. Rhinehart, Sergei G. Lokhov
Publikováno v:
Biochemistry. 36:14816-14826
Apparent equilibrium association constants were determined by gel mobility shift analysis for triple strand formation between a duplex target containing a 21 base long A-rich homopurine run and several end-modified C(m)/T (pyrimidine motif; C(m) = 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b9e3a0f4f64571095142c9ad8124fb5
https://doi.org/10.1021/bi971339+
https://doi.org/10.1021/bi971339+
Autor:
and Deborah D. Lucas, Rich B. Meyer, Igor V. Kutyavin, Michael W. Reed, Eugeny A. Lukhtanov, A. David Adams, Vladimir V. Gorn
Publikováno v:
Journal of the American Chemical Society. 119:6214-6225
Oligodeoxyribonucleotides (ODNs) with conjugated reactive groups are potential sequence-specific gene inactivating agents. The antitumor antibiotic CC-1065 binds preferably in the minor groove of A-T-rich sites of double-stranded DNA, and the cyclopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23cf180f1b43451b3b07e57fd5cca9d
https://doi.org/10.1021/ja9703133
https://doi.org/10.1021/ja9703133
Publikováno v:
Nucleic Acids Research. 24:2470-2475
Modified oligodeoxyribonucleotides (ODNs) that have unique hybridization properties were designed and synthesized for the first time. These ODNs, called selective binding complementary ODNs (SBC ODNs), are unable to form stable hybrids with each othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e404ef4e67bcc4f5857df1c431634445
https://doi.org/10.1093/nar/24.13.2470
https://doi.org/10.1093/nar/24.13.2470
Publikováno v:
Biochemistry. 35:7267-7274
Oligodeoxyribonucleotides (ODNs) bearing the reactive nitrogen mustard chlorambucil have been used as sequence-directed affinity labeling reagents to investigate the length and homology requirements for RecA-catalyzed alkylation of double-stranded DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c421f24b66d8dd0e108cb68a723b232e
https://doi.org/10.1021/bi9529465
https://doi.org/10.1021/bi9529465
Autor:
Howard Gamper, Eugeny A. Lukhtanov, Igor V. Kutyavin, Vladimir V. Gorn, Rebecca L. Rhinehart, Rich B. Meyer
Publikováno v:
Biochemistry. 35:11170-11176
A pair of complementary oligodeoxynucleotides (ODNs) uniformly substituted with 2-amino-adenine (A') in place of adenine and 2-thiothymine (T') in place of thymine did not hybridize to each other but did form very stable hybrids with unmodified compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a86aa3c90dc6d0c79b7653b1bfd0f50
https://doi.org/10.1021/bi960626v
https://doi.org/10.1021/bi960626v