Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Riccardo Zanaletti"'
Autor:
Simon N. Haydar, Jean Zhang, John Dunlop, Arianna Nencini, Laura Maccari, Elisa Turlizzi, Riccardo Zanaletti, Thomas A. Comery, Chiara Ghiron, Eva Genesio, Iolanda Micco, Cristiana Castaldo
Publikováno v:
European Journal of Medicinal Chemistry. 78:401-418
α7 nicotinic acetylcholine receptor agonists are promising therapeutic candidates for the treatment of cognitive impairment. As a follow up of our internal medicinal chemistry program we investigated a novel series of α7 nAChR agonists. Starting fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139ec03023d3491022a7083c4d811190
https://doi.org/10.1016/j.ejmech.2014.03.031
https://doi.org/10.1016/j.ejmech.2014.03.031
Autor:
Thomas A. Comery, John Dunlop, Laura Maccari, Eva Genesio, Flora Jow, Carmela Pratelli, Chiara Ghiron, Riccardo Zanaletti, Elisa Turlizzi, Ilaria Ceccarelli, Laura Bettinetti, Iolanda Micco, Carla Scali, Simon N. Haydar, Arianna Nencini, Michela Valacchi, Cristiana Castaldo, Giuseppe Cocconcelli
Publikováno v:
Journal of Medicinal Chemistry. 55:10277-10281
α7 Nicotinic acetylcholine receptors (α7 nAChR) represent promising therapeutic candidates for the treatment of cognitive impairment associated with Alzheimer's disease (AD) and schizophrenia. A medicinal chemistry effort around previously reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98800eb6cf37051f3ec70e6b3f324b99
https://doi.org/10.1021/jm3013568
https://doi.org/10.1021/jm3013568
Autor:
Riccardo Zanaletti, John Dunlop, Flora Jow, Laura Maccari, Michela Valacchi, Iolanda Micco, Elisa Turlizzi, Cristiana Castaldo, Giovanni Gaviraghi, Simon N. Haydar, Giuseppe Cocconcelli, Thomas A. Comery, Chiara Ghiron, Laura Bettinetti, Carla Scali, Arianna Nencini
Publikováno v:
Journal of Medicinal Chemistry. 55:4806-4823
Alpha-7 nicotinic acetylcholine receptors (α7 nAChR) are implicated in the modulation of many cognitive functions such as attention, working memory, and episodic memory. For this reason, α7 nAChR agonists represent promising therapeutic candidates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d0dae84961ada3602bc2ed9d734b4f
https://doi.org/10.1021/jm300247y
https://doi.org/10.1021/jm300247y
Publikováno v:
Synthetic Communications. 40:2547-2555
A new and efficient synthesis for the preparation of novel 4-fluoro-2H-pyrazol-3-ylamines is described. It involves the reaction of an acyl chloride with fluoroacetonitrile and sequential ring closure of the α-fluoro-β-ketonitrile with hydrazine. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dafe76eaed2ed6f8917aa0eca73f34e7
https://doi.org/10.1080/00397910903277912
https://doi.org/10.1080/00397910903277912
Autor:
William S. Brocklesby, Jeremy G. Frey, Abigail Rose, Mark Bradley, Jürgen Kress, Mark Ladlow, Riccardo Zanaletti
Publikováno v:
Journal of Combinatorial Chemistry. 5:28-32
Fluorescence microscopy is a powerful technique for analyzing beads with very low loadings of fluorophores; however, the method is flawed when looking at more highly loaded beads as a result of severe problems with absorption. To probe distributions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d87a36de1ebefbbae663c6e78fb2fe9
https://doi.org/10.1021/cc020024x
https://doi.org/10.1021/cc020024x
Publikováno v:
Journal of the American Chemical Society. 123:8366-8377
The reactivity of the alkylating agent o-quinone methide (o-QM) toward NH(3), H(2)O, and H(2)S, prototypes of nitrogen-, oxygen-, and sulfur-centered nucleophiles, has been studied by quantum chemical methods in the frame of DF theory (B3LYP) in reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bf42b60da3dcc6c886feec15a64ccd
https://doi.org/10.1021/ja010433h
https://doi.org/10.1021/ja010433h
Publikováno v:
The Journal of Organic Chemistry. 66:41-52
o-Quinone methide (1) has been produced in water both thermally and photochemically from (2-hydroxybenzyl)trimethylammonium iodide (2). Michael addition reactions of 1 to various amines, and sulfides, including amino acids and glutathione have been c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f8acb3211aadc6165409547b905cde
https://doi.org/10.1021/jo0006627
https://doi.org/10.1021/jo0006627
Publikováno v:
Tetrahedron. 56:2547-2559
endo–exo Selectivity in Diels–Alder cycloadditions of several o-quinodimethanes (1–4) with acrylonitrile, 2-(5H)-furanone and N-methylmaleimide has been investigated in acetonitrile solution. Transition structures of the cycloaddition of the pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a88e5b4cc5394eaf9e57be37b14137e6
https://doi.org/10.1016/s0040-4020(00)00126-5
https://doi.org/10.1016/s0040-4020(00)00126-5
Publikováno v:
ChemInform. 42
A set of novel 4-fluoro-2H-pyrazol-3-ylamines (IV) with different steric and electronic demands is synthesized.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0df4ea9847e177993ecc93f57e16287c
https://doi.org/10.1002/chin.201104118
https://doi.org/10.1002/chin.201104118
Autor:
Dianne Kowal, Ugo Zanelli, Riccardo Zanaletti, Laura Maccari, Maurizio Varrone, Albert J. Robichaud, Tim Lock, Michela Valacchi, Renza Roncarati, Carla Scali, Li Di, Georg C. Terstappen, Iolanda Micco, Flora Jow, Cristiana Castaldo, Arianna Nencini, Angela Kramer, Thomas A. Comery, John Dunlop, Suzan Aschmies, Hendrick Bothmann, Karen L. Marquis, Elisa Turlizzi, Chiara Ghiron, Giuseppe Cocconcelli, Salvatore La Rosa, Simon Haydar, Boyd L. Harrison, Joanna Quinn, Steven M. Grauer
Publikováno v:
Journal of medicinal chemistry. 53(11)
Alpha-7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists are promising therapeutic candidates for the treatment of cognitive impairment. We report a series of novel, potent small molecule agonists (4-18) of the alpha7 nAChR deriving from our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e335cbea368c3d67bdfa12e50c49f4
https://pubmed.ncbi.nlm.nih.gov/20465311
https://pubmed.ncbi.nlm.nih.gov/20465311