Výsledky vyhledávání - "Riccardo Secci"

Akademický článek

Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Autor: Franziska Meiners, Burkhard Hinz, Lars Boeckmann, Riccardo Secci, Salem Sueto, Lars Kuepfer, Georg Fuellen, Israel Barrantes

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract The major risk factor for chronic disease is chronological age, and age-related chronic diseases account for the majority of deaths worldwide. Targeting senescent cells that accumulate in disease-related tissues presents a strategy to reduce

Externí odkaz: https://doaj.org/article/62a77b3c732c490bb74fa1ced743bd23

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Akademický článek

Transcription Factor Activation Profiles (TFAP) identify compounds promoting differentiation of Acute Myeloid Leukemia cell lines

Autor: Federica Riccio, Elisa Micarelli, Riccardo Secci, Giulio Giuliani, Simone Vumbaca, Giorgia Massacci, Luisa Castagnoli, Claudia Fuoco, Gianni Cesareni

Publikováno v: Cell Death Discovery, Vol 8, Iss 1, Pp 1-13 (2022)

Abstract Repurposing of drugs for new therapeutic use has received considerable attention for its potential to limit time and cost of drug development. Here we present a new strategy to identify chemicals that are likely to promote a desired phenotyp

Externí odkaz: https://doaj.org/article/59d70f3c5f0241fa9bba1d69b88a806a

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Akademický článek

Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring

Autor: Alexander Hartmann, Christiane Hartmann, Riccardo Secci, Andreas Hermann, Georg Fuellen, Michael Walter

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Aging affects most living organisms and includes the processes that reduce health and survival. The chronological and the biological age of individuals can differ remarkably, and there is a lack of reliable biomarkers to monitor the consequences of a

Externí odkaz: https://doaj.org/article/454f6c4d242d4f6a908cac6d9992d6a0

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Biomarkers of geroprotection and cardiovascular health: An overview of omics studies and established clinical biomarkers in the context of diet

Autor: Georg Fuellen, Israel Barrantes, Sandra Van der Auwera-Palitschka, Michael Walter, Axel Kowald, Alexander Hartmann, Gerald Rimbach, Daniel Palmer, Hans J. Grabe, Riccardo Secci

Publikováno v: Critical reviews in food science and nutrition 63(15), 2426-2446 (2023). doi:10.1080/10408398.2021.1975638

The slowdown, inhibition, or reversal of age-related decline (as a composite of disease, dysfunction, and, ultimately, death) by diet or natural compounds can be defined as dietary geroprotection. While there is no single reliable biomarker to judge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940aa4661a376077c4f4a508518e20e6
https://pub.dzne.de/record/162781

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Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Autor: Franziska Meiners, Riccardo Secci, Salem Sueto, Georg Fuellen, Israel Barrantes

The highest risk factor for chronic diseases is chronological age, and age-related chronic diseases account for the majority of deaths worldwide. Targeting senescent cells that accumulate in disease-related tissues presents a strategy to reduce disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2ce78b6b93fd5ecab307d6e386343f0
https://doi.org/10.1101/2022.05.26.492763

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