Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Riccardo Parra"'
Autor:
Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale, Riccardo Parra, Antonia Gurgone, Daniela Lecca, Anna Cavaccini, Cezar M Tigaret, Alfredo Cagnotto, Kimberley Jones, Simon Brooks, Gian Michele Ratto, Nicholas D Allen, Mariah J Lelos, Silvia Middei, Maurizio Giustetto, Anna R Carta, Raffaella Tonini, Mario Salmona, Jeremy Hall, Kerrie Thomas, Riccardo Brambilla, Stefania Fasano
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death in vitro and in vivo in
Externí odkaz:
https://doaj.org/article/07ec956f4df240a18ad3746f40460254
Autor:
Francesco Trovato, Riccardo Parra, Enrico Pracucci, Silvia Landi, Olga Cozzolino, Gabriele Nardi, Federica Cruciani, Vinoshene Pillai, Laura Mosti, Andrzej W. Cwetsch, Laura Cancedda, Laura Gritti, Carlo Sala, Chiara Verpelli, Andrea Maset, Claudia Lodovichi, Gian Michele Ratto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Genetic mosaicism is frequently present in monogenic diseases of the central nervous system. Here the authors design a dual-colour reporter system that can be used to tune the degree of mosaicism in mouse models.
Externí odkaz:
https://doaj.org/article/1c4e916eb6864c37acafbefd423dd53f
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6981 (2021)
Epilepsy can be both a primary pathology and a secondary effect of many neurological conditions. Many papers show that neuroinflammation is a product of epilepsy, and that in pathological conditions characterized by neuroinflammation, there is a high
Externí odkaz:
https://doaj.org/article/faabd6191cef4db799d1db2eb7ec1431
Autor:
Matilde Marchi, Angela D'Antoni, Ivan Formentini, Riccardo Parra, Riccardo Brambilla, Gian Michele Ratto, Mario Costa
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3873 (2008)
The Extracellular Regulated Kinase 1 and 2 transduce a variety of extracellular stimuli regulating processes as diverse as proliferation, differentiation and synaptic plasticity. Once activated in the cytoplasm, ERK1 and ERK2 translocate into the nuc
Externí odkaz:
https://doaj.org/article/af3e28f554644fd28684924a691c853d
Autor:
Kaavian Shariati, Yaohuan Zhang, Simone Giubbolini, Riccardo Parra, Steven Liang, Austin Edwards, J. Fielding Hejtmancik, Gian Michele Ratto, Daniele Arosio, Gregory Ku
Publikováno v:
ACS Sensors. 7:2218-2224
Though the concentration of chloride has been measured in the cytoplasm and in secretory granules of live cells, it cannot be measured within the endoplasmic reticulum (ER) due to poor fluorescence of existing biosensors. We developed a fluorescent b
Autor:
Federica Cruciani, Enrico Pracucci, Laura Gritti, Laura Cancedda, Laura Mosti, Silvia Landi, Olga Cozzolino, Claudia Lodovichi, Riccardo Parra, Carlo Sala, Chiara Verpelli, Francesco Trovato, Gabriele Nardi, Vinoshene Pillai, Andrzej W. Cwetsch, Andrea Maset, Gian Michele Ratto
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature communications 11 (2020). doi:10.1038/s41467-020-19864-w
info:cnr-pdr/source/autori:Trovato F.; Parra R.; Pracucci E.; Landi S.; Cozzolino O.; Nardi G.; Cruciani F.; Pillai V.; Mosti L.; Cwetsch A.W.; Cancedda L.; Gritti L.; Sala C.; Verpelli C.; Maset A.; Lodovichi C.; Ratto G.M./titolo:Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter/doi:10.1038%2Fs41467-020-19864-w/rivista:Nature communications/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:11
Nature Communications
Nature communications 11 (2020). doi:10.1038/s41467-020-19864-w
info:cnr-pdr/source/autori:Trovato F.; Parra R.; Pracucci E.; Landi S.; Cozzolino O.; Nardi G.; Cruciani F.; Pillai V.; Mosti L.; Cwetsch A.W.; Cancedda L.; Gritti L.; Sala C.; Verpelli C.; Maset A.; Lodovichi C.; Ratto G.M./titolo:Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter/doi:10.1038%2Fs41467-020-19864-w/rivista:Nature communications/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:11
Genetic mosaicism, a condition in which an organ includes cells with different genotypes, is frequently present in monogenic diseases of the central nervous system caused by the random inactivation of the X-chromosome, in the case of X-linked patholo
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 6981, p 6981 (2021)
International journal of molecular sciences
22 (2021): 6981-1–6981-18. doi:10.3390/ijms22136981
info:cnr-pdr/source/autori:Pracucci E.; Pillai V.; Lamers D.; Parra R.; Landi S./titolo:Neuroinflammation: A signature or a cause of epilepsy?/doi:10.3390%2Fijms22136981/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:6981-1/pagina_a:6981-18/intervallo_pagine:6981-1–6981-18/volume:22
International Journal of Molecular Sciences, Vol 22, Iss 6981, p 6981 (2021)
International journal of molecular sciences
22 (2021): 6981-1–6981-18. doi:10.3390/ijms22136981
info:cnr-pdr/source/autori:Pracucci E.; Pillai V.; Lamers D.; Parra R.; Landi S./titolo:Neuroinflammation: A signature or a cause of epilepsy?/doi:10.3390%2Fijms22136981/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:6981-1/pagina_a:6981-18/intervallo_pagine:6981-1–6981-18/volume:22
Epilepsy can be both a primary pathology and a secondary effect of many neurological conditions. Many papers show that neuroinflammation is a product of epilepsy, and that in pathological conditions characterized by neuroinflammation, there is a high
Autor:
Stefania Fasano, Anna Cavaccini, Daniela Lecca, Maurizio Giustetto, Raffaella Tonini, Silvia Middei, Riccardo Parra, Alessandro Papale, Cezar M. Tigaret, Riccardo Brambilla, Jeremy Hall, Simon Philip Brooks, Ilaria Morella, Gian Michele Ratto, Daniel Orellana, Anna R. Carta, Marzia Indrigo, Antonia Gurgone, Raffaele d’Isa, Kerrie L. Thomas
Cell signalling mechanisms are central to neuronal activity and their dysregulation may lead to neurodegenerative processes and associated cognitive decline. So far, a major effort has been directed toward the dissection of disease specific pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af9d60e817eae877f09bcd1256fc742
Autor:
Riccardo Parra, Stefano Luin, Fabio Beltram, Pietro Artoni, Kai Kaila, Olga Cozzolino, Joanna Szczurkowska, Laura Cancedda, Enrico Pracucci, Silvia Landi, Daniele Arosio, Sebastian Sulis Sato, Francesco Trovato, Gian Michele Ratto
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 114 (2017): E8770–E8779. doi:10.1073/pnas.1702861114
info:cnr-pdr/source/autori:Sato SS, Artoni P, Landi S, Cozzolino O, Parra R, Pracucci E, Trovato F, Szczurkowska J, Luin S, Arosio D, Beltram F, Cancedda L, Kaila K, Ratto GM/titolo:Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo/doi:10.1073%2Fpnas.1702861114/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2017/pagina_da:E8770/pagina_a:E8779/intervallo_pagine:E8770–E8779/volume:114
Proceedings of the National Academy of Sciences of the United States of America (Online) 114 (2017): E8770–E8779. doi:10.1073/pnas.1702861114
info:cnr-pdr/source/autori:Sulis S.S.; Artoni P.; Landi S.; Cozzolino O.; Parra R.; Pracucci E.; Trovato F.; Szczurkowska J.; Luin S.; Arosio D.; Beltram F.; Cancedda L.; Kaila K.; Ratto G.M./titolo:Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo/doi:10.1073%2Fpnas.1702861114/rivista:Proceedings of the National Academy of Sciences of the United States of America (Online)/anno:2017/pagina_da:E8770/pagina_a:E8779/intervallo_pagine:E8770–E8779/volume:114
info:cnr-pdr/source/autori:Sato SS, Artoni P, Landi S, Cozzolino O, Parra R, Pracucci E, Trovato F, Szczurkowska J, Luin S, Arosio D, Beltram F, Cancedda L, Kaila K, Ratto GM/titolo:Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo/doi:10.1073%2Fpnas.1702861114/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2017/pagina_da:E8770/pagina_a:E8779/intervallo_pagine:E8770–E8779/volume:114
Proceedings of the National Academy of Sciences of the United States of America (Online) 114 (2017): E8770–E8779. doi:10.1073/pnas.1702861114
info:cnr-pdr/source/autori:Sulis S.S.; Artoni P.; Landi S.; Cozzolino O.; Parra R.; Pracucci E.; Trovato F.; Szczurkowska J.; Luin S.; Arosio D.; Beltram F.; Cancedda L.; Kaila K.; Ratto G.M./titolo:Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo/doi:10.1073%2Fpnas.1702861114/rivista:Proceedings of the National Academy of Sciences of the United States of America (Online)/anno:2017/pagina_da:E8770/pagina_a:E8779/intervallo_pagine:E8770–E8779/volume:114
Intracellular chloride ([Cl-](i)) andpH(pH(i)) are fundamental regulators of neuronal excitability. They exert wide-ranging effects on synaptic signaling and plasticity and on development and disorders of the brain. The ideal technique to elucidate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb930700d8398f995b001dc72e3f8b39
https://europepmc.org/articles/PMC5642681/
https://europepmc.org/articles/PMC5642681/
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 661
The action of ERK1 and ERK2 activity on the nuclear substrates requires crossing the nuclear envelope and the localization of phospho-ERK into the nucleus. The nucleo-cytoplasmic trafficking of ERK is therefore crucial for the correct functioning of