Výsledky vyhledávání - "Riccardo Ferdani"

Akademický článek

Evaluation of [Cu]Cu-DOTA and [Cu]Cu-CB-TE2A Chelates for Targeted Positron Emission Tomography with an αβ-Specific Peptide

Autor: Sven H. Hausner, David L. Kukis, M. Karen J. Gagnon, Catherine E. Stanecki, Riccardo Ferdani, John F. Marshall, Carolyn J. Anderson, Julie L. Sutcliffe

Publikováno v: Molecular Imaging, Vol 8 (2009)

Significant upregulation of the integrin α v β 6 has been described as a prognostic indicator in several cancers, making it an attractive target for tumor imaging. This study compares variants of a PEGylated α v β 6 -targeting peptide, bearing ei

Externí odkaz: https://doaj.org/article/6f6b4575e93d469e99ad93a943a6c830

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Molecular design of radiocopper-labelled Affibody molecules

Autor: Javad Garousi, Ying Yue, Johan Rajander, Riccardo Ferdani, Cheng-Bin Yim, Vladimir Tolmachev, Anna Perols, Anna Orlova, Amelie Eriksson Karlström, Sebastian Grimm, Carolyn J. Anderson, Olof Solin, Tove J. Grönroos, Merja Haaparanta-Solin

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports

The use of long-lived positron emitters 64Cu or 61Cu for labelling of Affibody molecules may improve breast cancer patients’ stratification for HER-targeted therapy. Previous animal studies have shown that the use of triaza chelators for 64Cu label

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857d3c5eca4cc94bef9a0b3390b7f3a6
https://doi.org/10.1038/s41598-018-24785-2

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Comparison of Conjugation Strategies of Cross-Bridged Macrocyclic Chelators with Cetuximab for Copper-64 Radiolabeling and PET Imaging of EGFR in Colorectal Tumor-Bearing Mice

Autor: Alexander G. White, Carolyn J. Anderson, Yunjun Guo, Zhengxin Cai, Dexing Zeng, Riccardo Ferdani, Jalpa Modi

Publikováno v: Molecular Pharmaceutics

Epidermal growth-factor receptor (EGFR) is overexpressed in a wide variety of solid tumors and has served as a well-characterized target for cancer imaging and therapy. Cetuximab was the first mAb targeting EGFR approved by the FDA for the treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ff8ad83a7639e99648f26313dcc2c5
https://doi.org/10.1021/mp500004m

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Preparation and Biological Evaluation of 64Cu Labeled Tyr3-Octreotate Using a Phosphonic Acid-Based Cross-Bridged Macrocyclic Chelator

Autor: Yunjun Guo, Riccardo Ferdani, Carolyn J. Anderson

Publikováno v: Bioconjugate Chemistry. 23:1470-1477

Somatostatin receptors (SSTr) are overexpressed in a wide range of neuroendocrine tumors, making them excellent targets for nuclear imaging and therapy, and radiolabeled somatostatin analogues have been investigated for positron emission tomography i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78908cdbf8c54389e103ff7af3fcd92f
https://doi.org/10.1021/bc300092n

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Isomeric Trimethylene and Ethylene Pendant-armed Cross-bridged Tetraazamacrocycles and in Vitro/in Vivo Comparisions of their Copper(II) Complexes

Autor: Edward H. Wong, Gary R. Weisman, Katie J. Heroux, Riccardo Ferdani, Thaddeus J. Wadas, Ashley L. Fiamengo, Daniel C. Hill, Carolyn J. Anderson, Yijie Peng, Arnold L. Rheingold, James A. Golen, Antoinette Y. Odendaal

Publikováno v: Inorganic Chemistry

Ethylene cross-bridged tetraamine macrocycles are useful chelators in coordination, catalytic, medicinal, and radiopharmaceutical chemistry. Springborg and co-workers developed trimethylene cross-bridged analogues, although their pendant-armed deriva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0961d8be47d2a81cc6fc9684f1f1191c
https://doi.org/10.1021/ic200014w

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In Vitro and In Vivo Evaluation of 64Cu-Labeled SarAr-Bombesin Analogs in Gastrin-Releasing Peptide Receptor–Expressing Prostate Cancer

Autor: Buck E. Rogers, Samuel Achilefu, Kexian Liang, Christopher D. Sherman, Riccardo Ferdani, Kimberly A. Lears, Rebecca Andrews, Alexander Zheleznyak, Carolyn J. Anderson

Publikováno v: Journal of Nuclear Medicine. 52:470-477

Bombesin is a 14–amino-acid amphibian peptide that binds with high affinity to the gastrin-releasing peptide receptor (GRPR), which is overexpressed on a variety of solid tumors. It has been demonstrated that bombesin analogs can be radiolabeled wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cf92170a1d28b91f2f43f958356fd8
https://doi.org/10.2967/jnumed.110.082826

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In VitroandIn VivoEvaluation of64Cu-Radiolabeled KCCYSL Peptides for Targeting Epidermal Growth Factor Receptor-2 in Breast Carcinomas

Autor: Riccardo Ferdani, Carolyn J. Anderson, Susan L. Deutscher, Senthil R. Kumar, Fabio Gallazzi, Thomas P. Quinn

Publikováno v: Cancer Biotherapy and Radiopharmaceuticals. 25:693-703

Epidermal growth factor receptor-2 (EGFR-2) has been implicated in the pathogenesis of breast and other carcinomas. In this report, we tested the ability of a bacteriophage selected peptide KCCYSL, radiolabeled with ⁶⁴Cu, to image EGFR-2 expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719b2cd198f371dcaea58554f4bb1d31
https://doi.org/10.1089/cbr.2010.0820

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111In-LLP2A-DOTA Polyethylene Glycol–Targeting α4β1 Integrin: Comparative Pharmacokinetics for Imaging and Therapy of Lymphoid Malignancies

Autor: Riccardo Ferdani, Simon R. Cherry, Julie L. Sutcliffe, Arutselvan Natarajan, Huguette Albrecht, Sally J. DeNardo, Carolyn J. Anderson, Li Peng, Kit S. Lam, Ruiwu Liu

Publikováno v: Journal of Nuclear Medicine. 50:625-634

N-[[4-[[[(2-ethylphenyl)amino]carbonyl]amino]phenyl]acetyl]-N(epsilon)-6-[(2E)-1-oxo-3-(3-pyridinyl-2-propenyl)]-l-lysyl-l-2-aminohexanedioyl-(1-amino-1-cyclohexane)carboxamide (LLP2A) is a high-affinity, high-specificity peptidomimetic ligand (inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f01d1c41c846ed8f8e7a2166b407440
https://doi.org/10.2967/jnumed.108.056903

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Copper-64 Radiopharmaceuticals for Oncologic Imaging

Autor: Jason P. Holland, Riccardo Ferdani, Carolyn J. Anderson, Jason S. Lewis

Publikováno v: PET Clinics. 4:49-67

The positron emitting radionuclide (64)Cu has a radioactive half-life of 12.7 hours. The decay characteristics of (64)Cu allow for PET images that are comparable in quality to those obtained using (18)F. Given the longer radioactive half-life of (64)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f54263aae304c3b411c720a044a26d2
https://doi.org/10.1016/j.cpet.2009.04.013

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Carboxylate Anion Diminishes Chloride Transport through a Synthetic, Self-Assembled Transmembrane Pore

Autor: Rudolph E. K. Winter, Riccardo Ferdani, Lei You, George W. Gokel, Ruiqiong Li, Joseph P. Kramer

Publikováno v: Chemistry - A European Journal. 14:382-396

Six amphiphilic heptapeptides with the structure (C 18 H 37 ) 2 NCO-CH 2 OCH 2 CO-(Gly)3-Pro-(Gly) n -(Glx)-(Gly) m -O(CH 2 ) 6 CH 3 , in which Glx represents glutamic acid or its benzyl ester and n+m=2, have been studied. In addition, the glutamate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c8c4a0c10628e930c4f482f5d9aaea
https://doi.org/10.1002/chem.200701071

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