Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Riccardo Brambilla"'
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
Externí odkaz:
https://doaj.org/article/88a26a82d85f4f4db04d943277bdcadb
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Neurodevelopmental disorders (NDDs) include a broad spectrum of pathological conditions that affect >4% of children worldwide, share common features and present a variegated genetic origin. They include clinically defined diseases, such as autism spe
Externí odkaz:
https://doaj.org/article/8629bf3dd9634fffb4c3993a57b0fdc2
Autor:
Perrine F. Kretz, Christel Wagner, Anna Mikhaleva, Charlotte Montillot, Sylvain Hugel, Ilaria Morella, Meghna Kannan, Marie-Christine Fischer, Maxence Milhau, Ipek Yalcin, Riccardo Brambilla, Mohammed Selloum, Yann Herault, Alexandre Reymond, Stephan C. Collins, Binnaz Yalcin
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-22 (2023)
Abstract Background Using mouse genetic studies and systematic assessments of brain neuroanatomical phenotypes, we set out to identify which of the 30 genes causes brain defects at the autism-associated 16p11.2 locus. Results We show that multiple ge
Externí odkaz:
https://doaj.org/article/37637093eaea40888cb9b6562d451f96
Autor:
Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale, Riccardo Parra, Antonia Gurgone, Daniela Lecca, Anna Cavaccini, Cezar M Tigaret, Alfredo Cagnotto, Kimberley Jones, Simon Brooks, Gian Michele Ratto, Nicholas D Allen, Mariah J Lelos, Silvia Middei, Maurizio Giustetto, Anna R Carta, Raffaella Tonini, Mario Salmona, Jeremy Hall, Kerrie Thomas, Riccardo Brambilla, Stefania Fasano
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death in vitro and in vivo in
Externí odkaz:
https://doaj.org/article/07ec956f4df240a18ad3746f40460254
Autor:
Ilaria Morella, Veronika Pohořalá, Claudia Calpe-López, Riccardo Brambilla, Rainer Spanagel, Rick E. Bernardi
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Ras/Raf/MEK/ERK (Ras-ERK) signaling has been demonstrated to play a role in the effects of drugs of abuse such as cocaine and alcohol, but has not been extensively examined in nicotine-related reward behaviors. We examined the role of Ras Guanine Nuc
Externí odkaz:
https://doaj.org/article/d93da21c946344f8a01c539c7f403ada
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
In the striatum, the input nucleus of the basal ganglia, the extracellular-signal-regulated kinase (ERK) pathway, necessary for various forms of behavioral plasticity, is triggered by the combined engagement of dopamine D1 and ionotropic glutamate re
Externí odkaz:
https://doaj.org/article/e15ce3af1d96469988cddd18ed3cadc4
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1099 (2021)
In the last two decades, abnormal Ras (rat sarcoma protein)–ERK (extracellular signal-regulated kinase) signalling in the brain has been involved in a variety of neuropsychiatric disorders, including drug addiction, certain forms of intellectual di
Externí odkaz:
https://doaj.org/article/4557875779384e07be7552d6eaf77b9a
Autor:
Valentina Iori, Anand M. Iyer, Teresa Ravizza, Luca Beltrame, Lara Paracchini, Sergio Marchini, Milica Cerovic, Cameron Hill, Mariella Ferrari, Massimo Zucchetti, Monica Molteni, Carlo Rossetti, Riccardo Brambilla, H. Steve White, Maurizio D'Incalci, Eleonora Aronica, Annamaria Vezzani
Publikováno v:
Neurobiology of Disease, Vol 99, Iss , Pp 12-23 (2017)
We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability underlying seizures in rodents. Since this pathway is activated in neuron
Externí odkaz:
https://doaj.org/article/6e1282d045224c0cb2029a5afa349aa9
Autor:
Thomas G. McWilliams, Erica Barini, Risto Pohjolan-Pirhonen, Simon P. Brooks, François Singh, Sophie Burel, Kristin Balk, Atul Kumar, Lambert Montava-Garriga, Alan R. Prescott, Sidi Mohamed Hassoun, François Mouton-Liger, Graeme Ball, Rachel Hills, Axel Knebel, Ayse Ulusoy, Donato A. Di Monte, Jevgenia Tamjar, Odetta Antico, Kyle Fears, Laura Smith, Riccardo Brambilla, Eino Palin, Miko Valori, Johanna Eerola-Rautio, Pentti Tienari, Olga Corti, Stephen B. Dunnett, Ian G. Ganley, Anu Suomalainen, Miratul M. K. Muqit
Publikováno v:
Open Biology, Vol 8, Iss 11 (2018)
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and defined how this dyad orchestrates the elimination of damaged mitocho
Externí odkaz:
https://doaj.org/article/1d714fdf77f7434a8620cf73ff0a6aee
Autor:
Massimo Trusel, Anna Cavaccini, Marta Gritti, Barbara Greco, Pierre-Philippe Saintot, Cristiano Nazzaro, Milica Cerovic, Ilaria Morella, Riccardo Brambilla, Raffaella Tonini
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1353-1365 (2015)
The basal ganglia play a critical role in shaping motor behavior. For this function, the activity of medium spiny neurons (MSNs) of the striatonigral and striatopallidal pathways must be integrated. It remains unclear whether the activity of the two
Externí odkaz:
https://doaj.org/article/17b73b6ef9de4c12b544f869027b9565