Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Riccardo, Filadi"'
Autor:
Paloma García Casas, Michela Rossini, Linnea Påvénius, Mezida Saeed, Nikita Arnst, Sonia Sonda, Tânia Fernandes, Irene D’Arsiè, Matteo Bruzzone, Valeria Berno, Andrea Raimondi, Maria Livia Sassano, Luana Naia, Elisa Barbieri, Sara Sigismund, Patrizia Agostinis, Mattia Sturlese, Barbara A. Niemeyer, Hjalmar Brismar, Maria Ankarcrona, Arnaud Gautier, Paola Pizzo, Riccardo Filadi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Membrane contact sites (MCSs) are hubs allowing various cell organelles to coordinate their activities. The dynamic nature of these sites and their small size hinder analysis by current imaging techniques. To overcome these limitations, we h
Externí odkaz:
https://doaj.org/article/0b6b5bb0acb9468497829472faf67a2f
Autor:
Riccardo Filadi, Agnese De Mario, Matteo Audano, Patrizia Romani, Silvia Pedretti, Cesar Cardenas, Sirio Dupont, Cristina Mammucari, Nico Mitro, Paola Pizzo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Rewiring of mitochondrial metabolism has been described in different cancers as a key step for their progression. Calcium (Ca2+) signaling regulates mitochondrial function and is known to be altered in several malignancies, including triple negative
Externí odkaz:
https://doaj.org/article/280b7091289047958911523f7c7ceea5
Autor:
Andrea Carrer, Ludovica Tommasin, Justina Šileikytė, Francesco Ciscato, Riccardo Filadi, Andrea Urbani, Michael Forte, Andrea Rasola, Ildikò Szabò, Michela Carraro, Paolo Bernardi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The nature of the mitochondrial permeability transition pore (PTP) is still under debate. Here, through genetically modified F-ATP synthase, the authors show that PTP formation can be mediated by F-ATP synthase or by adenine nucleotide translocator,
Externí odkaz:
https://doaj.org/article/ff86550a121a41e6be8159ac86257c13
Autor:
Luana Naia, Catarina M. Pinho, Giacomo Dentoni, Jianping Liu, Nuno Santos Leal, Duarte M. S. Ferreira, Bernadette Schreiner, Riccardo Filadi, Lígia Fão, Niamh M. C. Connolly, Pontus Forsell, Gunnar Nordvall, Makoto Shimozawa, Elisa Greotti, Emy Basso, Pierre Theurey, Anna Gioran, Alvin Joselin, Marie Arsenian-Henriksson, Per Nilsson, A. Cristina Rego, Jorge L. Ruas, David Park, Daniele Bano, Paola Pizzo, Jochen H. M. Prehn, Maria Ankarcrona
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-21 (2021)
Abstract Background Mitochondrial dysfunction is a common feature of aging, neurodegeneration, and metabolic diseases. Hence, mitotherapeutics may be valuable disease modifiers for a large number of conditions. In this study, we have set up a large-s
Externí odkaz:
https://doaj.org/article/4aff891322844c2cbd9f607edd6e7c04
Publikováno v:
Bio-Protocol, Vol 11, Iss 14 (2021)
The crucial role of hexokinase 2 (HK2) in the metabolic rewiring of tumors is now well established, which makes it a suitable target for the design of novel therapies. However, hexokinase activity is central to glucose utilization in all tissues; thu
Externí odkaz:
https://doaj.org/article/8055e79690b64ca89afbf7809c796b7f
Autor:
Michela Rossini, Riccardo Filadi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
In cardiomyocytes, to carry out cell contraction, the distribution, morphology, and dynamic interaction of different cellular organelles are tightly regulated. For instance, the repetitive close apposition between junctional sarcoplasmic reticulum (j
Externí odkaz:
https://doaj.org/article/055d56601c54425d94865054e17c2675
Autor:
Alice Rossi, Giulia Rigotto, Giulia Valente, Valentina Giorgio, Emy Basso, Riccardo Filadi, Paola Pizzo
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2332-2348.e10 (2020)
Summary: Mitochondria are key organelles for brain health. Mitochondrial alterations have been reported in several neurodegenerative disorders, including Alzheimer’s disease (AD), and the comprehension of the underlying mechanisms appears crucial t
Externí odkaz:
https://doaj.org/article/fdc78c49b4774370834040c16ee80882
Autor:
Riccardo Filadi, Paola Pizzo
Publikováno v:
Cells, Vol 11, Iss 5, p 834 (2022)
One of the major challenges of modern medicine is to block or prevent the neurodegenerative processes inevitably associated with different pathological conditions [...]
Externí odkaz:
https://doaj.org/article/346d8a96e0e647238ab8528df422ce71
Publikováno v:
Cells, Vol 10, Iss 8, p 1968 (2021)
Presenilin 2 (PS2), one of the three proteins in which mutations are linked to familial Alzheimer’s disease (FAD), exerts different functions within the cell independently of being part of the γ-secretase complex, thus unrelated to toxic amyloid p
Externí odkaz:
https://doaj.org/article/a3ea3bc2cd3f4858ba78c6ab9729e865
Autor:
Riccardo Filadi, Elisa Greotti, Gabriele Turacchio, Alberto Luini, Tullio Pozzan, Paola Pizzo
Publikováno v:
Cell Reports, Vol 15, Iss 10, Pp 2226-2238 (2016)
Communication between organelles plays key roles in cell biology. In particular, physical and functional coupling of the endoplasmic reticulum (ER) and mitochondria is crucial for regulation of various physiological and pathophysiological processes.
Externí odkaz:
https://doaj.org/article/2949ced184f94370b7ddf6757664b549