T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants.

Autor: Hirschhorn D; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA., Budhu S; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA., Kraehenbuehl L; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA; Department of Dermatology, University Hospital Zurich, Zurich, Switzerland., Gigoux M; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Schröder D; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Chow A; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Ricca JM; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Gasmi B; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., De Henau O; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Mangarin LMB; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA., Li Y; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hamadene L; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA., Flamar AL; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Choi H; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Cortez CA; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Liu C; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA., Holland A; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Schad S; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Schulze I; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA., Betof Warner A; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA., Hollmann TJ; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Arora A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Panageas KS; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rizzuto GA; Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Duhen R; Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA., Weinberg AD; Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, USA., Spencer CN; Department of Informatics, Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Ng D; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., He XY; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Albrengues J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Redmond D; Division of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Egeblad M; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Wolchok JD; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA; Department of Medicine and Graduate Schools, Weill Cornell Medicine, New York, NY, USA., Merghoub T; Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA; Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY, USA; Department of Medicine and Graduate Schools, Weill Cornell Medicine, New York, NY, USA. Electronic address: tmerghoub@med.cornell.edu.

Publikováno v: Cell [Cell] 2023 Mar 30; Vol. 186 (7), pp. 1432-1447.e17.

PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.

Autor: Zamarin D, Ricca JM, Sadekova S, Oseledchyk A, Yu Y, Blumenschein WM, Wong J, Gigoux M, Merghoub T, Wolchok JD

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2018 Nov 01; Vol. 128 (11), pp. 5184. Date of Electronic Publication: 2018 Oct 02.

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.

Autor: Ricca JM; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Swim Across America-Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Oseledchyk A; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Walther T; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Swim Across America-Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Liu C; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Swim Across America-Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Mangarin L; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Swim Across America-Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Merghoub T; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Swim Across America-Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Wolchok JD; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Swim Across America-Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA., Zamarin D; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Swim Across America-Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: zamarind@mskcc.org.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2018 Apr 04; Vol. 26 (4), pp. 1008-1019. Date of Electronic Publication: 2018 Jan 31.

A Multifaceted Role for Myd88-Dependent Signaling in Progression of Murine Mammary Carcinoma.

Autor: Higgins MJ; Department of Biology, Lafayette College, Easton, PA, USA., Serrano A; Department of Biology, Lafayette College, Easton, PA, USA., Boateng KY; Department of Biology, Lafayette College, Easton, PA, USA., Parsons VA; Department of Biology, Lafayette College, Easton, PA, USA., Phuong T; Department of Biology, Lafayette College, Easton, PA, USA., Seifert A; Department of Biology, Lafayette College, Easton, PA, USA., Ricca JM; Department of Biology, Lafayette College, Easton, PA, USA., Tucker KC; Department of Biology, Lafayette College, Easton, PA, USA., Eidelman AS; Department of Biology, Lafayette College, Easton, PA, USA., Carey MA; Department of Biology, Lafayette College, Easton, PA, USA., Kurt RA; Department of Biology, Lafayette College, Easton, PA, USA.

Publikováno v: Breast cancer : basic and clinical research [Breast Cancer (Auckl)] 2016 Oct 27; Vol. 10, pp. 157-167. Date of Electronic Publication: 2016 Oct 27 (Print Publication: 2016).