Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ricardo Vilain"'
Mind Over Matter: Confronting Challenges in Post-Mortem Brain Biobanking for Glioblastoma Multiforme
Autor:
Cassandra Griffin, Ricardo Vilain, Simon King, Sandy Nixon, Alisha Gooley, Samara Bray, James Lynam, Marjorie M Walker, Rodney J Scott, Christine Paul
Publikováno v:
Biomarker Insights, Vol 16 (2021)
Over the past 10 years, there has been limited progress for the treatment of brain cancer and outcomes for patients are not much improved. For brain cancer researchers, a major obstacle to biomarker driven research is limited access to brain cancer t
Externí odkaz:
https://doaj.org/article/f6d05b6c361e4a10a6d62940556d9c80
Autor:
Richard A. Scolyer, Georgina V. Long, Peter Hersey, Richard F. Kefford, John F. Thompson, Jennifer H. Yearley, Lauren E. Haydu, Ricardo Vilain, Alexander M. Menzies, James S. Wilmott, Hojabr Kakavand
Supplementary Figure 3. Kaplan-Meier plots for progression-free survival (PFS) and overall survival (OS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5d7b6610dc84789eaa921b1b362cc9
https://doi.org/10.1158/1078-0432.22458542
https://doi.org/10.1158/1078-0432.22458542
Autor:
James S. Wilmott, Richard A. Scolyer, Graham J. Mann, Georgina V. Long, John F. Thompson, Jeen Y. H. Yang, Alexander M. Menzies, Ricardo Vilain, Dario Strbenac, Jason Madore
Correlation between PD-L1 gene expression (RNAseq) and PD-L1 immunohistochemistry score (r2 = 0.711, p = 3.33E-09). Green diamonds = PD-L1 negative by immunohistochemistry; Empty diamonds = PD-L1 positive by immunohistochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bd949dbb079c94fdfe5b9c7eff8791
https://doi.org/10.1158/1078-0432.22457675.v1
https://doi.org/10.1158/1078-0432.22457675.v1
Autor:
James S. Wilmott, Richard A. Scolyer, Graham J. Mann, Georgina V. Long, John F. Thompson, Jeen Y. H. Yang, Alexander M. Menzies, Ricardo Vilain, Dario Strbenac, Jason Madore
Purpose: Understanding why some melanomas test negative for PD-L1 by IHC may have implications for the application of anti-PD-1 therapies in melanoma management. This study sought to determine somatic mutation and gene expression patterns associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd1547fbcf1450184c27124b73a11e8
https://doi.org/10.1158/1078-0432.c.6523646.v1
https://doi.org/10.1158/1078-0432.c.6523646.v1
Autor:
James S. Wilmott, Richard A. Scolyer, Graham J. Mann, Georgina V. Long, John F. Thompson, Jeen Y. H. Yang, Alexander M. Menzies, Ricardo Vilain, Dario Strbenac, Jason Madore
Table S1 - Summary of Gene Set Enrichment Analysis (GSEA) results for pathways with FDR < 0.05.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13e49499427dc69e96094fce7d8e50f
https://doi.org/10.1158/1078-0432.22457660
https://doi.org/10.1158/1078-0432.22457660
Autor:
Richard A. Scolyer, Georgina V. Long, Peter Hersey, Richard F. Kefford, John F. Thompson, Jennifer H. Yearley, Lauren E. Haydu, Ricardo Vilain, Alexander M. Menzies, James S. Wilmott, Hojabr Kakavand
Supplementary Figure 4. Decision tree used to categorize the pattern of PD-L1 positive staining based on the immune cell infiltrate, percentage of tumor cells expressing PD-L1 and the location of staining within the samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af6b86e443eb6573dd1998876fb881a
https://doi.org/10.1158/1078-0432.22458539
https://doi.org/10.1158/1078-0432.22458539
Autor:
Richard A. Scolyer, Georgina V. Long, Peter Hersey, Richard F. Kefford, John F. Thompson, Jennifer H. Yearley, Lauren E. Haydu, Ricardo Vilain, Alexander M. Menzies, James S. Wilmott, Hojabr Kakavand
Supplementary Figure 1. Heat map of patients grouped based on baseline (PRE) PD-L1, change in (Δ) PD-L1 expression, Δ tumor infiltrating lymphocytes (TILs) and Δ PD-1+ lymphocytes from PRE to early during treatment (EDT).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c813a3c841709e65cc9b80699cbaf6b
https://doi.org/10.1158/1078-0432.22458548.v1
https://doi.org/10.1158/1078-0432.22458548.v1
Autor:
Richard A. Scolyer, Georgina V. Long, Peter Hersey, Richard F. Kefford, John F. Thompson, Jennifer H. Yearley, Lauren E. Haydu, Ricardo Vilain, Alexander M. Menzies, James S. Wilmott, Hojabr Kakavand
Supplementary Table 2. The percentage of PD-L1 expressing tumor/immune cells and the intensity of staining in these samples used to derive the immuno-reactive score (IRS) for the 40 patients. *Immune cells= lymphocytes and macrophages.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8c57c186e2cd1b86060be953af8129
https://doi.org/10.1158/1078-0432.22458533
https://doi.org/10.1158/1078-0432.22458533
Autor:
Richard A. Scolyer, Georgina V. Long, Peter Hersey, Richard F. Kefford, John F. Thompson, Jennifer H. Yearley, Lauren E. Haydu, Ricardo Vilain, Alexander M. Menzies, James S. Wilmott, Hojabr Kakavand
Purpose: To evaluate the expression of tumor PD-L1 and changes in tumor-infiltrating lymphocyte (TIL) populations in patients with metastatic melanoma treated with targeted MAPK inhibitors.Experimental Design: Ninety-three tumors were analyzed from 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddfb030e1e14170a4fd7681269dc07e
https://doi.org/10.1158/1078-0432.c.6523985.v1
https://doi.org/10.1158/1078-0432.c.6523985.v1
Autor:
Richard A. Scolyer, Georgina V. Long, Peter Hersey, Richard F. Kefford, John F. Thompson, Jennifer H. Yearley, Lauren E. Haydu, Ricardo Vilain, Alexander M. Menzies, James S. Wilmott, Hojabr Kakavand
Supplementary Figure 2. LAG3 and FoxP3 expressing lymphocytes at PRE, EDT and PROG. Patients treated with either BRAFi (A-B) or Combi (C-D) showed no significant changes in LAG3+ and FoxP3+ lymphocytes at any time point.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e33819ba7ec9e0e4dcae176661980b
https://doi.org/10.1158/1078-0432.22458545
https://doi.org/10.1158/1078-0432.22458545