Blood gene expression biomarkers of response to anti-TNF drugs in pediatric inflammatory bowel diseases before initiation of treatment

Autor: Sara Salvador-Martín, Gianluca Rubbini, Perceval Vellosillo, Paula Zapata-Cobo, Marta Velasco, Laura M. Palomino, Susana Clemente, Oscar Segarra, Ana Moreno-Álvarez, Ana Fernández-Lorenzo, Begoña Pérez-Moneo, Montserrat Montraveta, Cesar Sánchez, Mar Tolín, Inés Loverdos, María José Fobelo, Victor Manuel Navas-López, Lorena Magallares, Ruth García-Romero, Ricardo Torres-Peral, Alejandro Rodríguez, Ferrán Bossacoma, Vicente Merino-Bohórquez, Enrique Salcedo, Rebeca Álvarez, Ana Dopazo, María Sanjurjo-Sáez, Luis A. López-Fernández

Publikováno v: Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116299- (2024)

Background/aims: Changes in gene expression profiles among individuals with inflammatory bowel diseases (IBDs) could potentially influence the responsiveness to anti-TNF treatment. The aim of this study was to identify genes that could serve as predi

Externí odkaz: https://doaj.org/article/4b0faa08ee99409eb3ae49564d84206d

Spanish National Registry of Paediatric Coeliac Disease: Changes in the Clinical Presentation in the 21st Century

Autor: David, Pérez Solís, Ma Luz, Cilleruelo Pascual, Carlos, Ochoa Sangrador, Jose Ignacio, García Burriel, Félix, Sánchez-Valverde Visus, Francisco Javier, Eizaguirre Arocena, Salvador, Garcia Calatayud, Eva, Martinez-Ojinaga Nodal, Ester, Donat Aliaga, Josefa, Barrio Torres, Gemma, Castillejo de Villasante, Ma Del Carmen, Miranda Cid, Ricardo, Torres Peral, Raquel, Vecino Lopez, Mercedes, Juste Ruiz, Honorio, Armas Ramos, Patricia, Barros Garcia, Rosaura, Leis Trabazo, Rosa, Solaguren Alberdi, José Carlos, Salazar Quero, Ruth, Garcia Romero, Luis, Ortigosa Del Clastillo, Luis, Peña Quintana, Pedro, Urruzuno Telleria, Pilar, Codoñer Franch, Zuriñe, Garcia Casales, Maria Lluïsa, Masiques Mas, Gonzalo, Galicia Poblet, Cecilia, Martinez Costa, Elena, Balmaseda Serrano, Isabel, Polanco Allué, Carmen, Ribes Koninck, Enriqueta, Román Riechmann, Myriam, Herrero Álvarez

Publikováno v: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Over the last several decades, there has been a tendency towards a predominance of less symptomatic forms of coeliac disease (CD) and an increase in the patient age at diagnosis. This study aimed to assess the clinical presentation and diagnostic pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5afdb07e25f31d883dd6c41224a9590
https://pubmed.ncbi.nlm.nih.gov/35192578

Safety and effectiveness of vedolizumab in paediatric patients with inflammatory bowel disease: an observational multicentre Spanish study

Autor: Montserrat Montraveta, Ester Donat-Aliaga, Saioa Vicente-Santamaría, José Miguel Martínez de Zabarte Fernández, Ignacio Ros-Arnal, Marta Velasco Rodríguez-Belvís, Laura Escartin-Madurga, R. García-Romero, Sonia Fernández-Fernández, Ricardo Torres-Peral, Víctor Manuel Navas-López, Enrique Medina-Benitez, Iñaki Irastorza-Terradillos, Carlos José Ruiz-Hernández, Gemma Pujol-Muncunill, Marta Carrillo-Palau, María Navalon-Rubio, José Ramón Alberto-Alonso, Alejandro Rodriguez-Martinez, Javier Martín de Carpi, Oscar Segarra-Cantón, Carolina Gutiérrez-Junquera

Publikováno v: EUROPEAN JOURNAL OF PEDIATRICS
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
European Journal of Pediatrics
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol

Vedolizumab is a humanised monoclonal antibody that binds to integrin alpha 4 beta 7 expressed in T-cells, inhibiting its binding to the mucosal addressin cell adhesion molecule-1 (MAdCAM-1), which is specifically expressed in the small intestine and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a52cea01239d2307a466cdc9b70935e
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19433

Genetic Predictors of Long-term Response to Antitumor Necrosis Factor Agents in Pediatric Inflammatory Bowel Disease

Autor: Xandra García-González, José A. Blanca-García, María Sanjurjo-Sáez, Oscar Segarra, Vicente Merino-Bohórquez, Elena Aznal, María Jesús Balboa-Vega, Ana Moreno-Álvarez, Rafael González de Caldas, José Germán Sánchez-Hernández, Antonio Millán-Jiménez, Susana Clemente, Alejandro Rodriguez-Martinez, María J. Fobelo, Lorena Magallares, R. García-Romero, Víctor Manuel Navas-López, Gemma Pujol-Muncunill, Javier Viada, Concepción Alvarez-Vayo, Mar Tolin, Ricardo Torres-Peral, César Sánchez, Francisco J. Eizaguirre, Alfonso Solar-Boga, Ferrán Bossacoma, Luis A. López-Fernández, Eva Martínez-Ojinaga, Rosana Muñoz-Codoceo, Sara Salvador-Martín, Inés Loverdos, Carmen Gallego-Fernández

Publikováno v: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname

OBJECTIVES: Inflammatory bowel disease (IBD) is more complex in children and they will have to live with the disease for much longer. For this reason, it is necessary to optimize treatment. The polymorphisms associated with the response to anti-tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf22153d99369d66cc05501deea2d60
https://journals.lww.com/jpgn/Fulltext/2020/10000/Genetic_Predictors_of_Long_term_Response_to.18.aspx

The complete picture of changing pediatric inflammatory bowel disease incidence in Spain in 25 years (1985-2009): the EXPERIENCE registry

Autor: Manuel Barreiro de Acosta, ANA ECHARRI, Carolina Gutiérrez-Junquera, Luis Peña-Quintana, Josefa Barrio, Begoña Pérez-Moneo Agapito, Oscar Segarra, Ricardo Torres-Peral, Daniel Carpio, Esther Ramos Boluda, Santiago Jiménez

Publikováno v: Journal of Crohn'scolitis. 8(8)

Objectives A growing incidence of pediatric IBD (PIBD) in southern Europe has been recently reported. The SPIRIT registry (1996–2009) confirmed these tendencies in Spain. Our aim is to obtain data from 1985 to 1995 and describe the complete picture

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1973d0cac25f495bc7aee27b9cd0086
https://pubmed.ncbi.nlm.nih.gov/24462789