Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Ricardo Rajsbaum"'
Autor:
Carlos A Rodríguez-Salazar, Sarah van Tol, Olivier Mailhot, Maria Gonzalez-Orozco, Gabriel T Galdino, Abbey N Warren, Natalia Teruel, Padmanava Behera, Kazi Sabrina Afreen, Lihong Zhang, Terry L Juelich, Jennifer K Smith, María Inés Zylber, Alexander N Freiberg, Rafael J Najmanovich, Maria I Giraldo, Ricardo Rajsbaum
Publikováno v:
PLoS Biology, Vol 22, Iss 2, p e3002544 (2024)
Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase complex, which includes the cofactor and Interferon antagonist VP35. We p
Externí odkaz:
https://doaj.org/article/99a4e0e8910746299e1402b8c51819c3
Publikováno v:
Viruses, Vol 15, Iss 11, p 2147 (2023)
Nipah virus (NiV; genus: Henipavirus; family: Paramyxoviridae) naturally infects Old World fruit bats (family Pteropodidae) without causing overt disease. Conversely, NiV infection in humans and other mammals can be lethal. Comparing bat antiviral re
Externí odkaz:
https://doaj.org/article/af6e44ad4fe941bcb71b15c8c885f3fd
Autor:
Sarah van Tol, Birte Kalveram, Philipp A Ilinykh, Adam Ronk, Kai Huang, Leopoldo Aguilera-Aguirre, Preeti Bharaj, Adam Hage, Colm Atkins, Maria I Giraldo, Maki Wakamiya, Maria Gonzalez-Orozco, Abbey N Warren, Alexander Bukreyev, Alexander N Freiberg, Ricardo Rajsbaum
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010532 (2022)
Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging, viral polymerase function, and host immune antagonism. The mechanisms regulating VP35's engagement in different functions are not well-understood. We previously s
Externí odkaz:
https://doaj.org/article/7f5b774b9b474e8c892f3effa42555aa
Autor:
Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I. Giraldo, Maria Gonzalez-Orozco, Karl M. Valerdi, Abbey N. Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G. Widen, Hong M. Moulton, Benhur Lee, Jeffrey R. Johnson, Nevan J. Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N. Freiberg, Ricardo Rajsbaum
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110434- (2022)
Summary: Type I interferons (IFN-I) are essential to establish antiviral innate immunity. Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses. However, few unanchored poly-Ub interactors are known. To identify fact
Externí odkaz:
https://doaj.org/article/1021a0c2a2e14ca9810fefd46e1864bc
Autor:
Hongjie Xia, Zengguo Cao, Xuping Xie, Xianwen Zhang, John Yun-Chung Chen, Hualei Wang, Vineet D. Menachery, Ricardo Rajsbaum, Pei-Yong Shi
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108234- (2020)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased scree
Externí odkaz:
https://doaj.org/article/038c1377c0384558868e240b88eab5d3
Autor:
Hongjie Xia, Huanle Luo, Chao Shan, Antonio E. Muruato, Bruno T. D. Nunes, Daniele B. A. Medeiros, Jing Zou, Xuping Xie, Maria Isabel Giraldo, Pedro F. C. Vasconcelos, Scott C. Weaver, Tian Wang, Ricardo Rajsbaum, Pei-Yong Shi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The Asian lineage of Zika virus (ZIKV) has acquired a mutation in NS1 that enhances mosquito infection. Here, Xia et al. show that the same mutation interferes with interferon production through interaction with TBK1 and affects ZIKV replication in m
Externí odkaz:
https://doaj.org/article/a273eacb2a3240279d0531f686d0666c
Publikováno v:
Viruses, Vol 13, Iss 3, p 369 (2021)
Ubiquitination of proteins is a post-translational modification process with many different cellular functions, including protein stability, immune signaling, antiviral functions and virus replication. While ubiquitination of viral proteins can be us
Externí odkaz:
https://doaj.org/article/57e76e43589649a7b54df8425ddb9059
Autor:
Preeti Bharaj, Yao E Wang, Brian E Dawes, Tatyana E Yun, Arnold Park, Benjamin Yen, Christopher F Basler, Alexander N Freiberg, Benhur Lee, Ricardo Rajsbaum
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005880 (2016)
For efficient replication, viruses have developed mechanisms to evade innate immune responses, including the antiviral type-I interferon (IFN-I) system. Nipah virus (NiV), a highly pathogenic member of the Paramyxoviridae family (genus Henipavirus),
Externí odkaz:
https://doaj.org/article/ba0da777b7ea4d80b4ea6b3307a3d2e3
Publikováno v:
Vaccines, Vol 5, Iss 3, p 23 (2017)
The innate antiviral response is integral in protecting the host against virus infection. Many proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin-activating (E1), -conjugating (E2), and -ligating (E3) enzymes work t
Externí odkaz:
https://doaj.org/article/e745f8d1241040218ef9c70c44bd55dc
Autor:
Juliet Morrison, Maudry Laurent-Rolle, Ana M Maestre, Ricardo Rajsbaum, Giuseppe Pisanelli, Viviana Simon, Lubbertus C F Mulder, Ana Fernandez-Sesma, Adolfo García-Sastre
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003265 (2013)
An estimated 50 million dengue virus (DENV) infections occur annually and more than forty percent of the human population is currently at risk of developing dengue fever (DF) or dengue hemorrhagic fever (DHF). Despite the prevalence and potential sev
Externí odkaz:
https://doaj.org/article/c2c13699c8a14e3d9f30cc12b62340bf