Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ricardo Pires das Neves"'
Autor:
Emanuel Quartin, Susana Rosa, Sara Gonzalez-Anton, Laura Mosteo Lopez, Vitor Francisco, Delfim Duarte, Cristina Lo Celso, Ricardo Pires das Neves, Lino Ferreira
Publikováno v:
Bioactive Materials, Vol 34, Iss , Pp 311-325 (2024)
More effective approaches are needed in the treatment of blood cancers, in particular acute myeloid leukemia (AML), that are able to eliminate resistant leukemia stem cells (LSCs) at the bone marrow (BM), after a chemotherapy session, and then enhanc
Externí odkaz:
https://doaj.org/article/0ce74d83bac54803992be667dee97677
Autor:
Hélder Almeida-Lousada, André Mestre, Sara Ramalhete, Aryeh J. Price, Ramon Andrade de Mello, Ana D. Marreiros, Ricardo Pires das Neves, Pedro Castelo-Branco
Publikováno v:
Current Oncology, Vol 28, Iss 6, Pp 4874-4893 (2021)
Colorectal cancer (CRC) has an important bearing (top five) on cancer incidence and mortality in the world. The etiology of sporadic CRC is related to the accumulation of genetic and epigenetic alterations that result in the appearance of cancer hall
Externí odkaz:
https://doaj.org/article/5240602abd744704b4f3d2b9aa71247a
Autor:
Ricardo Pires das Neves, Mónica Chagoyen, Antonio Martinez-Lorente, Carlos Iñiguez, Ana Calatrava, Juana Calabuig, Francisco J. Iborra
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1274 (2023)
Signaling and detoxification of Reactive Oxygen Species (ROS) are important patho-physiologcal processes. Despite this, we lack comprehensive information on individual cells and cellular structures and functions affected by ROS, which is essential to
Externí odkaz:
https://doaj.org/article/b02ebaa97a214756a59820e2df82b197
Autor:
Catarina Domingues, A. Margarida Geraldo, Sandra Isabel Anjo, André Matos, Cláudio Almeida, Inês Caramelo, José A. Lopes-da-Silva, Artur Paiva, João Carvalho, Ricardo Pires das Neves, Bruno Manadas, Mário Grãos
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The mechanical properties of the extracellular environment are interrogated by cells and integrated through mechanotransduction. Many cellular processes depend on actomyosin-dependent contractility, which is influenced by the microenvironment’s sti
Externí odkaz:
https://doaj.org/article/21954e7199324ff8915f565dbd0db6f7
Autor:
Silvia Márquez-Jurado, Juan Díaz-Colunga, Ricardo Pires das Neves, Antonio Martinez-Lorente, Fernando Almazán, Raúl Guantes, Francisco J. Iborra
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
It is unclear what causes variation in cell death in response to chemotherapy. Here, the authors show that cellular mitochondrial content modulates apoptotic protein levels, which in turn regulates response to agents such as TRAIL.
Externí odkaz:
https://doaj.org/article/29db1d8ce1734f508ff800f6141230b0
Autor:
Sílvia C. Rodrigues, Renato M. S. Cardoso, Patricia C. Freire, Cláudia F. Gomes, Filipe V. Duarte, Ricardo Pires das Neves, Joana Simões-Correia
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9797 (2021)
Umbilical cord blood (UCB) has long been seen as a rich source of naïve cells with strong regenerative potential, likely mediated by paracrine signals. More recently, small extracellular vesicles (sEV), such as exosomes, have been shown to play esse
Externí odkaz:
https://doaj.org/article/6860bc966f2843e288254485edaae632
Autor:
Carlos Boto, Emanuel Quartin, Yijun Cai, Alberto Martín-Lorenzo, María Begoña García Cenador, Sandra Pinto, Rajeev Gupta, Tariq Enver, Isidro Sánchez-García, Dengli Hong, Ricardo Pires das Neves, Lino Ferreira
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Leukaemia cells resident in the bone marrow niche are often resistant to conventional therapies. In this study, the authors develop light-sensitive, polymeric, retinoic acid-containing nanoparticles that are able to modulate the differentiation of re
Externí odkaz:
https://doaj.org/article/e4bdd43ae19445c3acce605c66e63d91
Autor:
Alan Diot, Thomas Agnew, Jeremy Sanderson, Chunyan Liao, Janet Carver, Ricardo Pires das Neves, Rajeev Gupta, Yanping Guo, Caroline Waters, Sharon Seto, Matthew J. Daniels, Eszter Dombi, Tiffany Lodge, Karl Morten, Suzannah A. Williams, Tariq Enver, Francisco J. Iborra, Marcela Votruba, Joanna Poulton
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Background: Autosomal dominant optic atrophy (ADOA) is usually caused by mutations in the essential gene, OPA1. This encodes a ubiquitous protein involved in mitochondrial dynamics, hence tissue specificity is not understood. Dysregulated mitophagy (
Externí odkaz:
https://doaj.org/article/0360b3470f94428a8df73eee35831c9f
Autor:
Iain G Johnston, Bernadett Gaal, Ricardo Pires das Neves, Tariq Enver, Francisco J Iborra, Nick S Jones
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 3, p e1002416 (2012)
We present a study investigating the role of mitochondrial variability in generating noise in eukaryotic cells. Noise in cellular physiology plays an important role in many fundamental cellular processes, including transcription, translation, stem ce
Externí odkaz:
https://doaj.org/article/82408ccaf4d2433c9af0c10e33ca99ff
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17771 (2011)
In this study we demonstrate that CD34(+) cells derived from human embryonic stem cells (hESCs) have higher smooth muscle cell (SMC) potential than CD34(-) cells. We report that from all inductive signals tested, retinoic acid (RA) and platelet deriv
Externí odkaz:
https://doaj.org/article/741ff8506203400caa8446657cedfb2b