Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Ricardo M, Biondi"'
Autor:
Lorena González, Lucía Díaz, Joan Pous, Blazej Baginski, Anna Duran-Corbera, Margherita Scarpa, Isabelle Brun-Heath, Ana Igea, Pau Martin-Malpartida, Lidia Ruiz, Chiara Pallara, Mauricio Esguerra, Francesco Colizzi, Cristina Mayor-Ruiz, Ricardo M. Biondi, Robert Soliva, Maria J. Macias, Modesto Orozco, Angel R. Nebreda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of p38α signaling has been linked to several diseases including inflammation, immune disord
Externí odkaz:
https://doaj.org/article/875e0b5f72914dd0a22c1161dc475f7f
Autor:
María-Natalia Lisa, Adrià Sogues, Nathalie Barilone, Meike Baumgart, Magdalena Gil, Martín Graña, Rosario Durán, Ricardo M. Biondi, Marco Bellinzoni, Michael Bott, Pedro M. Alzari
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Bacteria control the metabolic processes by which they obtain nutrients and energy in order to adapt to the environment. ActinobacteriaCorynebacterium glutamicum
Externí odkaz:
https://doaj.org/article/f5c4c9e092da4dcfa7ad0596f347263e
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242819 (2020)
Three AKT serine/threonine kinase isoforms (AKT1/AKT2/AKT3) mediate proliferation, metabolism, differentiation and anti-apoptotic signals. AKT isoforms are activated downstream of PI3-kinase and also by PI3-kinase independent mechanisms. Mutations in
Externí odkaz:
https://doaj.org/article/51e3a2e5fc8b41dc88f8267a1c3e0471
Autor:
Thomas Pleli, Antonia Mondorf, Nerea Ferreiros, Dominique Thomas, Karel Dvorak, Ricardo M. Biondi, Dagmar Meyer zu Heringdorf, Stefan Zeuzem, Gerd Geisslinger, Herbert Zimmermann, Oliver Waidmann, Albrecht Piiper
Publikováno v:
Cellular Physiology and Biochemistry, Vol 45, Iss 6, Pp 2516-2528 (2018)
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation of adenylyl cyclase, causing an increase of the intracellular cAMP concentration, activation of the intracellular cAMP effectors protein kinase A (PKA)
Externí odkaz:
https://doaj.org/article/0a4e904e6a144be5903bf729f11e5b78
Autor:
Suresh Velnati, Sara Centonze, Federico Girivetto, Daniela Capello, Ricardo M. Biondi, Alessandra Bertoni, Roberto Cantello, Beatrice Ragnoli, Mario Malerba, Andrea Graziani, Gianluca Baldanzi
Publikováno v:
Biomedicines, Vol 9, Iss 1, p 45 (2021)
PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these kinases, we systematically explored their interactions
Externí odkaz:
https://doaj.org/article/d160aa80871e40f3b7a90d2d631d42d9
Autor:
Nicolas A Pabon, Yan Xia, Samuel K Estabrooks, Zhaofeng Ye, Amanda K Herbrand, Evelyn Süß, Ricardo M Biondi, Victoria A Assimon, Jason E Gestwicki, Jeffrey L Brodsky, Carlos J Camacho, Ziv Bar-Joseph
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 12, p e1006651 (2018)
An expanded chemical space is essential for improved identification of small molecules for emerging therapeutic targets. However, the identification of targets for novel compounds is biased towards the synthesis of known scaffolds that bind familiar
Externí odkaz:
https://doaj.org/article/34634c75dc7c43d1b7435c229390e398
Autor:
Martin Schröder, Ricardo M. Biondi, Apirat Chaikuad, Larissa Pietsch, Vladimir V. Rogov, Robert Fürst, Jessica Huber, Markus Hartmann, Iris Bischoff, Ewgenij Proschak, Jan Heering, Holger Stark, Volker Dötsch, Dalibor Odadzic, Masato Akutsu, Jan S. Kramer, Stefan Knapp
Publikováno v:
Journal of Medicinal Chemistry. 64:3720-3746
Autophagy is the common name for a number of lysosome-based degradation pathways of cytosolic cargos. The key components of autophagy are members of Atg8 family proteins involved in almost all steps of the process, from autophagosome formation to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1734a07131d3cf598f0f8ba7195fc073
https://doi.org/10.1021/acs.jmedchem.0c01564
https://doi.org/10.1021/acs.jmedchem.0c01564
Autor:
Ricardo M. Biondi, Claudia Chiriches, Elizabeh Eshel, Oliver G. Ottmann, Larissa Pietsch, Dally Najib, Isabella Haberbosch, Martin Ruthardt, Oliver Hantschel, Abed Agbarya, Jamal Mahajna, Afsar Ali Mian, Hazem Khamaisie
Resistance remains the major clinical challenge for the therapy of Philadelphia chromosome–positive (Ph+) leukemia. With the exception of ponatinib, all approved tyrosine kinase inhibitors (TKIs) are unable to inhibit the common “gatekeeper” mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065257f72ea9b48d1b46e14465a4f7c1
https://orca.cardiff.ac.uk/id/eprint/136955/8/Mian2021_Article_CrizotinibActsAsABL1InhibitorC.pdf
https://orca.cardiff.ac.uk/id/eprint/136955/8/Mian2021_Article_CrizotinibActsAsABL1InhibitorC.pdf
Autor:
Nathalie Barilone, Pedro M. Alzari, Magdalena Gil, Marco Bellinzoni, Ricardo M. Biondi, Adrià Sogues, Michael Bott, María-Natalia Lisa, Rosario Durán, Meike Baumgart, Martín Graña
Signal transduction is essential for bacteria to adapt to changing environmental conditions. Among many forms of post-translational modifications, reversible protein phosphorylation has evolved as a ubiquitous molecular mechanism of protein regulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f9b7e2f9545609b4ce997886578c950
https://doi.org/10.1101/2021.06.11.448168
https://doi.org/10.1101/2021.06.11.448168