Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ricardo Linares-Saldana"'
Autor:
Leela Chakravarti Dilley, Milan Szuperak, Naihua N Gong, Charlette E Williams, Ricardo Linares Saldana, David S Garbe, Mubarak Hussain Syed, Rajan Jain, Matthew S Kayser
Publikováno v:
eLife, Vol 9 (2020)
Across species, sleep in young animals is critical for normal brain maturation. The molecular determinants of early life sleep remain unknown. Through an RNAi-based screen, we identified a gene, pdm3, required for sleep maturation in Drosophila. Pdm3
Externí odkaz:
https://doaj.org/article/ebe57810f12442c992556901772cfb41
Autor:
Nikhita A. Bolar, Li Li, Arun Padmanabhan, Ashley Karnay, Haoyue Zhang, Danny S. Park, Ricardo Linares-Saldana, Andrey Poleshko, Wonho Kim, Jennifer M. Luppino, Gerd A. Blobel, Gwang Hyeon Eom, Qiaohong Wang, Eric F. Joyce, Golnaz Vahedi, Rajan Jain, Parisha P. Shah, Cheryl L. Smith, Deepak Srivastava, Son C. Nguyen, Sora Yoon, Bailey A Koch-Bojalad
Publikováno v:
Nat Genet
Nature genetics, vol 53, iss 10
Nature genetics, vol 53, iss 10
Higher-order chromatin structure regulates gene expression, and mutations in proteins mediating genome folding underlie developmental disorders known as cohesinopathies. However, the relationship between three-dimensional genome organization and embr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7601ad5b545c01e68e8754c077c47a30
https://europepmc.org/articles/PMC8500624/
https://europepmc.org/articles/PMC8500624/
Autor:
Parisha P. Shah, Arun Padmanabhan, Franco Felix, Ricardo Linares-Saldana, Rajan Jain, Andrew J. Connolly, Qiming Duan, Michael Alexanian, Qiaohong Wang, Wonho Kim, Saptarsi M. Haldar, Austin Hsu, Gaia Andreoletti, Yu Huang, Sarah A. B. Winchester, Juan A. Perez-Bermejo, Bárbara González-Terán, Li Li, Deepak Srivastava
Publikováno v:
Circulation, vol 142, iss 24
Background: Gene regulatory networks control tissue homeostasis and disease progression in a cell type–specific manner. Ubiquitously expressed chromatin regulators modulate these networks, yet the mechanisms governing how tissue specificity of thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2f901da1e37ad46432723db6cc69f5
https://escholarship.org/uc/item/9592f6t2
https://escholarship.org/uc/item/9592f6t2
Autor:
Arun Padmanabhan, Katherine S. Pollard, Joshua G. Travers, Ricardo Linares-Saldana, Kathryn N. Ivey, Pawel F. Przytycki, Jin Yang, Michael G. Rosenfeld, Barbara Gonzalez Teran, Franco Felix, Gaia Andreoletti, Qiming Duan, Deepak Srivastava, Michael Alexanian, Rudi Micheletti, Sanjeev S. Ranade, Saptarsi M. Haldar, Lin Ye, Yu Huang, Casey A. Gifford, Rajan Jain, Timothy A. McKinsey
In diseased organs, stress-activated signaling cascades alter chromatin, triggering broad shifts in transcription and cell state that exacerbate pathology. Fibroblast activation is a common stress response that worsens lung, liver, kidney and heart d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f822752ed23f4eccecada4498b5950e0
https://doi.org/10.1101/2020.07.21.214874
https://doi.org/10.1101/2020.07.21.214874
Autor:
Rajan Jain, Ricardo Linares-Saldana, Rudi Micheletti, Pawel F. Przytycki, Arun Padmanabhan, Katherine S. Pollard, Sanjeev S. Ranade, Lin Ye, Li Li, Ana C. Silva, Bárbara González-Terán, Angelo Pelonero, Qiming Duan, Saptarsi M. Haldar, Nandhini Sadagopan, Joshua G. Travers, Michael Alexanian, Deepak Srivastava, Clara Youngna Lee, Franco Felix, Michael G. Rosenfeld, Gaia Andreoletti, Timothy A. McKinsey, Yu Huang, Casey A. Gifford
Publikováno v:
Signal Transduction and Targeted Therapy
Nature
Nature, vol 595, iss 7867
Nature
Nature, vol 595, iss 7867
In diseased organs, stress-activated signalling cascades alter chromatin, thereby triggering maladaptive cell state transitions. Fibroblast activation is a common stress response in tissues that worsens lung, liver, kidney and heart disease, yet its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67b4799c8e327071d007123e085da0e
https://pubmed.ncbi.nlm.nih.gov/34952898
https://pubmed.ncbi.nlm.nih.gov/34952898
Autor:
Yu Huang, Wonho Kim, Michael Alexanian, Sarah A. B. Winchester, Ricardo Linares-Saldana, Bárbara González-Terán, Gaia Andreoletti, Rajan Jain, Andrew J. Connolly, Arun Padmanabhan, Austin Hsu, Deepak Srivastava, Qiming Duan, Saptarsi M. Haldar
Gene regulatory networks control tissue plasticity during basal homeostasis and disease in a cell-type specific manner. Ubiquitously expressed chromatin regulators modulate these networks, yet the mechanisms governing how tissue-specificity of their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43f6589592809c82a743846574f63b9
Autor:
Rajan Jain, Haoyue Zhang, Parisha P. Shah, Li Li, Wonho Kim, Nikhita A. Bolar, Qiaohong Wang, Ricardo Linares-Saldana, Jennifer M. Luppino, Bailey A Koch-Bojalad, Arun Padmanabhan, Gwang Hyeon Eom, Cheryl L. Smith, Gerd A. Blobel, Deepak Srivastava, Sora Yoon, Eric F. Joyce, Golnaz Vahedi, Ashley Karnay, Andrey Poleshko, Danny S. Park, Son C. Nguyen
Publikováno v:
Nature Genetics. 53:1723-1723
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f0c7df40d1250e71336f1e7651ded71
https://doi.org/10.1038/s41588-021-00980-2
https://doi.org/10.1038/s41588-021-00980-2
Publikováno v:
Chromosoma. 126:595-604
The centromere directs chromosome segregation and genetic inheritance but is not itself heritable in a canonical, DNA-based manner. In most species, centromeres are epigenetically defined by the presence of a histone H3 variant centromere protein A (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351eee940fab80a95de84369acc33e2d
https://doi.org/10.1007/s00412-017-0640-y
https://doi.org/10.1007/s00412-017-0640-y
Autor:
Minqi Lu, Katharine G. Stolz, Li Li, Michael Morley, Edward E. Morrisey, Josh Pankin, Jarod A. Zepp, William J. Zacharias, David B. Frank, Apoorva Babu, Ian J. Penkala, Su Zhou, Rajan Jain, Qiaohong Wang, Aravind Sivakumar, Ricardo Linares-Saldana
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(10)
During the stepwise specification and differentiation of tissue-specific multipotent progenitors, lineage-specific transcriptional networks are activated or repressed to orchestrate cell specification. The gas-exchange niche in the lung contains two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc438854a43bd981b733b74f594588c
https://pubmed.ncbi.nlm.nih.gov/30782824
https://pubmed.ncbi.nlm.nih.gov/30782824
Autor:
Parisha P. Shah, Deepti Abbey, Kiran Musunuru, David B. Frank, Dilip Thomas, Wenli Yang, Thomas P. Cappola, Ricardo Linares-Saldana, Michael Morley, Matthew A. Caporizzo, Daniel J. Rader, Wenjian Lv, Rajan Jain, Andrey Poleshko, Kenneth Bedi, Julie Heffler, Joshua H. Rhoades, Anjali T. Owens, Joseph C. Wu, Liam J. Stanton, Qiaohong Wang, Nazish Sayed, Kenneth B. Margulies, Benjamin L. Prosser
Publikováno v:
Cell stem cell, vol 28, iss 5
Cell Stem Cell
Cell Stem Cell
Pathogenic mutations in LAMIN A/C (LMNA) cause abnormal nuclear structure and laminopathies. These diseases have myriad tissue-specific phenotypes, including dilated cardiomyopathy (DCM), but how LMNA mutations result in tissue-restricted disease phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d379934670af20c9b8df8e5d1c703dc
https://doi.org/10.1016/j.stem.2020.12.016
https://doi.org/10.1016/j.stem.2020.12.016