Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Ricardo Laguna-Barraza"'
1
Akademický článek
Zrsr2 and functional U12-dependent spliceosome are necessary for follicular development
Autor: Isabel Gómez-Redondo, Eva Pericuesta, Paula Navarrete-Lopez, Priscila Ramos-Ibeas, Benjamín Planells, Noelia Fonseca-Balvís, Aida Vaquero-Rey, Raúl Fernández-González, Ricardo Laguna-Barraza, Keiko Horiuchi, Alfonso Gutiérrez-Adán
Publikováno v: iScience, Vol 25, Iss 2, Pp 103860- (2022)
Summary: ZRSR2 is a splicing factor involved in recognition of 3′-intron splice sites that is frequently mutated in myeloid malignancies and several tumors; however, the role of mutations of Zrsr2 in other tissues has not been analyzed. To explore
Externí odkaz: https://doaj.org/article/dbc4d6a69a474e8ba5832f984bbeea28
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2
Akademický článek
ZP4 Is Present in Murine Zona Pellucida and Is Not Responsible for the Specific Gamete Interaction
Autor: Mª José Izquierdo-Rico, Carla Moros-Nicolás, Míriam Pérez-Crespo, Ricardo Laguna-Barraza, Alfonso Gutiérrez-Adán, Frédéric Veyrunes, José Ballesta, Vincent Laudet, Pascale Chevret, Manuel Avilés
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Mammalian eggs are surrounded by an extracellular matrix called the zona pellucida (ZP). This envelope participates in processes such as acrosome reaction induction, sperm binding, protection of the oviductal embryo, and may be involved in speciation
Externí odkaz: https://doaj.org/article/f158673f8e804a8986784e0d7c7ea276
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3
Akademický článek
TMEM95 is a sperm membrane protein essential for mammalian fertilization
Autor: Ismael Lamas-Toranzo, Julieta G Hamze, Enrica Bianchi, Beatriz Fernández-Fuertes, Serafín Pérez-Cerezales, Ricardo Laguna-Barraza, Raúl Fernández-González, Pat Lonergan, Alfonso Gutiérrez-Adán, Gavin J Wright, María Jiménez-Movilla, Pablo Bermejo-Álvarez
Publikováno v: eLife, Vol 9 (2020)
The fusion of gamete membranes during fertilization is an essential process for sexual reproduction. Despite its importance, only three proteins are known to be indispensable for sperm-egg membrane fusion: the sperm proteins IZUMO1 and SPACA6, and th
Externí odkaz: https://doaj.org/article/0ee4dbc451934916835f7457ae5ab563
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4
Akademický článek
Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice
Autor: Keiko Horiuchi, Serafín Perez-Cerezales, Panagiotis Papasaikas, Priscila Ramos-Ibeas, Angela Patricia López-Cardona, Ricardo Laguna-Barraza, Noelia Fonseca Balvís, Eva Pericuesta, Raul Fernández-González, Benjamín Planells, Alberto Viera, Jose Angel Suja, Pablo Juan Ross, Francisco Alén, Laura Orio, Fernando Rodriguez de Fonseca, Belén Pintado, Juan Valcárcel, Alfonso Gutiérrez-Adán
Publikováno v: Cell Reports, Vol 23, Iss 1, Pp 143-155 (2018)
Summary: The U2AF35-like ZRSR1 has been implicated in the recognition of 3′ splice site during spliceosome assembly, but ZRSR1 knockout mice do not show abnormal phenotypes. To analyze ZRSR1 function and its precise role in RNA splicing, we generat
Externí odkaz: https://doaj.org/article/d212e33fab784884b791d952a00bf831
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5
Akademický článek
Intracytoplasmic sperm injection using DNA-fragmented sperm in mice negatively affects embryo-derived embryonic stem cells, reduces the fertility of male offspring and induces heritable changes in epialleles.
Autor: Priscila Ramos-Ibeas, Alexandra Calle, Raúl Fernández-González, Ricardo Laguna-Barraza, Eva Pericuesta, Antonia Calero, Miguel Ángel Ramírez, Alfonso Gutiérrez-Adán
Publikováno v: PLoS ONE, Vol 9, Iss 4, p e95625 (2014)
Intracytoplasmic sperm injection (ICSI) in mice using DNA-fragmented sperm (DFS) has been linked to an increased risk of genetic and epigenetic abnormalities both in embryos and offspring. This study examines: whether embryonic stem cells (ESCs) deri
Externí odkaz: https://doaj.org/article/fb610a8c45d84d43aa3b3d678d5c20ac
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6
Longitudinal analysis of somatic and germ‐cell telomere dynamics in outbred mice
Autor: Irene Peral‐Sanchez, Sonia Heras, Priscila Ramos-Ibeas, Eva Pericuesta, Ricardo Laguna-Barraza, Alfonso Gutiérrez-Adán, Serafín Pérez-Cerezales
Publikováno v: Molecular Reproduction and Development. 86:1033-1043
Although telomere length (TL) shortens with age in most tissues, an age-related increase in length has been described in sperm through a mechanism that is not yet fully understood. Changes in TL with age in the same individual have not been explored.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b674763ddd34dfb0b52fdf9988d13d65
https://doi.org/10.1002/mrd.23218
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7
Effects of Zrsr2 Mutations in Mice Oogenesis, Peripheral Blood Cells and Muscle Strength
Autor: Priscila Ramos-Ibeas, Noelia Fonseca-Balvís, Keiko Horiuchi, Serafín Pérez-Cerezales, Isabel Gómez-Redondo, Ricardo Laguna-Barraza, Eva Pericuesta, Raúl Fernández, Alfonso Gutiérrez-Adán, Benjamín Planells, Aida Vaquero-Rey
Publikováno v: SSRN Electronic Journal.
ZRSR2 is a splicing factor essential for 3’ss recognition of U12-type introns and is frequently mutated in myeloid malignancies and in several tumors. To explore the biological role of ZRSR2 we generated three Zrsr2 mutant mice with deletions local
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::916158fc74f6d64ab4ee1ff2c6a14257
https://doi.org/10.2139/ssrn.3844736
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8
D-Chiro-Inositol Treatment Affects Oocyte and Embryo Quality and Improves Glucose Intolerance in Both Aged Mice and Mouse Models of Polycystic Ovarian Syndrome
Autor: Carlos Sanjuan, Elena Baixeras, Priscila Ramos-Ibeas, Fernando Rodríguez de Fonseca, Ricardo Laguna-Barraza, Eva Pericuesta, Julia L. Gutiérrez-Arroyo, Alfonso Gutiérrez-Adán, Juan A. Navarro, Katia Vera
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6049, p 6049 (2020)
Volume 21
Issue 17
Polycystic ovarian syndrome (PCOS) is the main cause of female infertility. It is a multifactorial disorder with varying clinical manifestations including metabolic/endocrine abnormalities, hyperandrogenism, and ovarian cysts, among other conditions.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae46c7c633b2898986527adbc31a31a5
http://europepmc.org/articles/PMC7504697
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10
Effects of the HDAC inhibitor scriptaid on the in vitro development of bovine embryos and on imprinting gene expression levels
Autor: Dimitrios Rizos, M.J. Sánchez-Calabuig, Serafín Pérez-Cerezales, Alfonso Gutiérrez-Adán, Ricardo Laguna-Barraza
Publikováno v: Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
INIA: Repositorio de Resultados de Investigación del INIA
This study examines the effects of the histone deacetylation inhibitor scriptaid (SCR) on preimplantation embryo development in vitro and on imprinting gene expression. We hypothesized that SCR would increase histone acetylation levels, enhance embry
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e845ec2a6404d892c57ccaf45c0e49
https://doi.org/10.1016/j.theriogenology.2017.12.043
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